<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26729

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWNQASASIPAAAMGGGSGNPNSSMAHTTAGPFASHARSTSIANGPPTHRRTTGGVGPAQHASSPSSNPIFPRPFPNAAFPGTVSAPRSAAAPNTALATPRSIQHLSLLTTETPTSIARLAFPPHTAIYWHRLQKNSDAPATTTGHDHQRQDAATSSTAASASSSPSWHTGVQRVLSSANKSRSQPRAPEEVHGQDHAALQRLLKVPLVYASSKVSPSESLASSTSKAELWIFAVVTDQDGLSDNATSASIIEATDTGAAHASNRDADASQDAAAAARGDSTPLDPTLARHLPADLVKSLSRLSTSAHASSGSYRLSAAATNSIDGKGKQSSLTSQQRKAHKRFMASIKARFIDSLASGQPTSPKQKRDRLRLGDSVVFLPSRSSGLSSTATNDAGWFAAPGRPKTSLGGVSDSRCLLTQLAVSLTATSLYVRATSRPLAALPLINTRFASISTPLPPSPARPTLLIAPLGCHVELAGMVPTTLVAQEHLSELGSAFAGFGTAPNDPSPFASGVAICAFPQSPSGLQSHQDQPHLQDPQQLPEASLVPSAQGEASDQDMPLAAPSSAGIDRESANATGQGSLQFLWPAAWCLVVQDRATASTGALGLGSNATNDLKSMQSQPMTPLKELVSFTLKMLNDANESALAQGTAPYTPGEPDDASLARHRASTRADITPASLSFADFDFAMPTAGSATSSHALPAAGQSVPPGTASPLKRESTSIEPAQAANSTEAFGQDLNWMQFLPPQGSEAPASSSEPAFAMQIDATSAGSILNATAKVTDEAKHSHIDPTSTNWLLSGNSSSVPESGATAAAHAPNTAASQSLLQPLPQMQSHESTPFQGQHATTPLGFAQPTSSKRKAGEGDIFGNLGLLTEDDFSFFDESAFGLDAEGDLAQHMDQTAEGVSMGPSQHHLTFDQPQAGANHATAPNMSMANEAQPASSTAPAVIDDVAMEDVGQSSLDALFSAIPGLQDAMASSESSHPQSAPLQTSLSTSATAVSQLAPPRLGHSAAQDMTVANAGSTHAFHPAMSSFTPRDASGATPFGDPASLPGFTPSSLTESSPAFGNPHYKTPRTPYSPAEEFRDGATIVDLHNGHRMGESAQGYRDRNAASAPDLHASDQHPLSGHKADTLLHDDQQLRLADASTAAAAAANAAMETDASSRKRTAIVPNAFLPLRPPEARKPLQRLPAGARANLGRKYDLLGKFAPRPKTATATATATAAAMNASNAPTTTEHPSSGDAGKVAERTDGQNVPESGRQGNLPAVTRPSPAKTPSHRGQALLQLRRDRHGKSSPGLALTNLGRSSSSRAAEGPATPRSSDDVILAGAMSASDGDTSDSADDDSDDALSDSEATALTLSPQDQATLKDVSLDVVASYLCGASHVFRTHWPAASSAAVDQTNENASTLGPLIMPPLPLSRAVATASIVGTAAASSSPPRPTLRRWMLSRTAAWLIQNPQFRCMYGMRGASSTPGSELAIGDKIDVLEAMASALSIAAAPAPTNEAAETRTAAANTEAEAAVPTLRDLVRPSKHVAGVAGVAADGVEVAEVLEPTRIAAGCQGSVVEALPSSLTLWDKSKLSAVSGQKHIVAKVLLTDASPAWHEEIVAWLERLRVAFETHGLGTHVGDAQSILAVADGSESLALSSCLDRLWQDGETWLDTLRSISSRVEVDLLQGKHVVVYTLQPPNSSACASTGFRGLLRLEADLRAMLSEQVGVLAEQLLVRAVSPSMMTESGSLGFGQQSQTLRRLAFSVYDQLPRLVRRQPAKVLHGREAGPISAVVQFPAFSLSTVSASGASKTGRTNLSLGWPQEPAAALDEHVLLHISYRVCQTGPREQAEQDSNASLVATRVFGLSGLADGGQVASTTTTPRERIVLVSAIDERGGSSTVEALAANDGDSSIEACVERVWRFALAEASRARVRWRLAVSSAEVMSQRELAAWQRMIGSYTATTEAEERVMGSVELLSVRPDEAGAVVAERGGRTKPSQPWAATADKSSLVLLDAADFSQMVRFAEPMPMGWTQAVAEEEEAADDDDEEDKEGDEKDALALPIASAMLVHRSRPDLLSSTANKMHRLDGGASASQVLAVDMLYRWTGSGTEQQQQQHEEAQDEAAQEEAMDAILRSLHRLRLLSEERHQLAWPYTAQPWSVASVNTLAACLEGIVLDD
Length2162
PositionKinase
OrganismSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Sporisorium.
Aromaticity0.04
Grand average of hydropathy-0.298
Instability index52.26
Isoelectric point5.54
Molecular weight225874.11
Publications
PubMed=21148393

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26729
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     509.30|      82|      82|     842|     923|       1
---------------------------------------------------------------------------
  519-  566 (54.31/17.42)	..........FPQS..PS.G.......................L.QSHQ..........DQPHLQDpQQ.LPE.....AS.LVPS.AQGEASDQ...........................D.......MPL......A................AP...SS.............................
  646-  676 (31.25/ 6.30)	......................................................................AQG........TAPY.TPGEPDD...................AS.................L......A................RH...RAS...TR............ADI.TP....A
  677-  776 (78.84/29.25)	SLSFADFDFaMPTA..GS.A.......................T.SSHA...........LP.AAG.QS.VPP.....GT.ASPL.KRESTSIE.PAQAAN...........STE......AfgqdlnwMQFlppqgsE................AP...ASS...SEPAfamqidatSAGSI.LNA..TA
  795-  837 (40.84/10.93)	LLSGNS.SS.VPES.......................................................gATA.....AA.HAPNtAASQSLLQ.PLPQMQS.........HEST......P.....................................................................
  870-  955 (108.06/43.34)	LLTEDDFSF.FDES..AF.G.......................L.DAEG..........DLAQHMD.QT.AEG.....VS.MGPS.QHHLTFDQ.PQAGANHatapnmsmaNE.........................A................QP...ASS...TAPA........VIDDVaMED..VG
  956- 1046 (62.89/21.56)	QSSLD..AL.F..S..AIpG.......................LqDAMAssesshpqsaPLQTSLS.TS.ATA.....VSqLAP...........PRLG..H.........SAAQ......D.......MTV......A........nagsthafHP...AMSsftPRDA........SGATP.FGD..PA
 1047- 1173 (56.50/18.48)	SLPGFTPSS.LTESspAF.GnphyktprtpyspaeefrdgatiV.DLHN............GHRMG.ES.AQGyrdrnAA.SAPD.L.HAS.DQhPLSG..H.........KADTllhddqQ.......LRL......AdastaaaaaanaametDA...SSR...KRTA............I.VPNafLP
 1247- 1314 (76.61/28.17)	.....DGQN.VPES.....G.......................R.Q..G..........NLPAV....T.RPS.....PA.KTPS.HRGQALLQ..LRRDRH.........GKSS......P........GL......A................LTnlgRSS...SSRA........AEGPA.TP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.53|      45|      46|     104|     148|       2
---------------------------------------------------------------------------
   28-   65 (40.99/15.95)	TTAG..PfasharsTSIAN...GP.PT.........HRRTTGGVGP............aQHASSP
   66-  109 (52.26/22.81)	SSNPifP.......RPFPNAAFPG.TVSA..........PRSAAAPntALATPRSI...QHLSLL
  110-  154 (79.87/39.61)	TTET..P.......TSIARLAFPP.HTAIY.....WHRLQKNSDAP..ATTTGHDH...QRQDAA
  155-  203 (41.41/16.21)	TSST..A.......ASAS..SSPSwHTGVQrvlssANKSRSQPRAP..EEVHGQDHaalQRL...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     727.80|     201|     209|    1604|    1811|       3
---------------------------------------------------------------------------
 1548- 1733 (239.57/146.37)	.........................EPTRIAAGcqgsvVEAL......P.SSLTLWDKSKLSAVSGQKhiVAKVLL..TDASPAW...........heeivawLER...LRVAFETHGL.....GTHVGDAQSILAVADGSESLALSSCLDRLWQDGETW..LDTLRSISSRV....EVDLL.....QGKHVV.VYTLQPPNSS..ACASTGFRGLLRLEADLRAMLSEQVGVLAEQLLVRAVSPSMMTESGS
 1736- 1943 (275.62/178.96)	FGQQSQTLRRLAFSVyDQLPrlVRRQPAKVLHG.....REAG......PISAVVQFPAFSLSTVSASG..ASKTGR..TNLSLGWPQ.....EPAA......aLDEhvlLHISYRVCQT.....GPREQAEQDSNASLVATRVFGLSG.....LADGGQV..ASTTTTPRERIvlvsAIDER.....GGSSTVeALAANDGDSSieACVERVWRFAL.AEAS.RARVRWRLAVSSAEVMSQRELAAWQRMIGS
 1944- 2135 (212.61/123.44)	YTATTEAEERVMGSV.ELLS..VRPDEAGAVVA.....ERGGrtkpsqPWAATAD..KSSLVLLDAAD..FSQMVRfaEPMPMGWTQavaeeEEAA.......................ddddeEDKEGDEKDALALPIASAMLVHRSRPDLLSSTANKMhrLDGGASASQVL....AVDMLyrwtgSGTEQQ.QQQHEEAQDE..AAQEEAMDAILRSLHRLR.LLSEERHQLA..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.10|      40|     287|    1205|    1244|       4
---------------------------------------------------------------------------
 1205- 1244 (68.80/32.29)	APRP...KTATATATATAAAMNASNA..PTTTE..HPSSGDAG.........KVAE
 1381- 1406 (28.60/ 8.21)	VFR.......THWPAASSAAVDQTNE..NASTL..GP...................
 1410- 1452 (56.70/25.04)	PPLPlsrAVATASIVGTAAASSSPPR..PTLRR..WMLSRTAA.........WLIQ
 1494- 1545 (42.99/16.83)	APAP....TNEAAETRTAAANTEAEAavPTLRDlvRPSKHVAGvagvaadgvEVAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.75|      30|      94|     334|     364|       6
---------------------------------------------------------------------------
  334-  364 (49.26/30.75)	TSQQRKAHKRFMAS...IKARFIdSLASGQPTSP
  428-  460 (48.50/25.76)	TSLYVRATSRPLAAlplINTRFA.SISTPLPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.68|      12|      68|     311|     322|       8
---------------------------------------------------------------------------
  311-  322 (21.37/11.15)	SGSYRLSAAATN
  382-  393 (20.31/10.16)	SRSSGLSSTATN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.18|      27|     187|     283|     309|       9
---------------------------------------------------------------------------
  283-  309 (48.60/24.52)	PL..DPTLARHLPADLV..KSLSRLSTSAHA
  469-  498 (35.75/16.01)	PLgcHVELAGMVPTTLVaqEHLSELG.SAFA
 1174- 1192 (29.84/12.10)	.L..RPPEAR.........KPLQRLPAGARA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26729 with Med13 domain of Kingdom Fungi
Unable to open file!