<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26724

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSRSTDAGPSTVPAAPPKEVQLSVEPVHIYTDPDPYPSNSTGAAHTILDAFERERKLQDITADGTNVFATRKPASVQLGEDVRRLWAERGDFSRFRTSQLMRGKREREQESVASSSDDDEEDGADMEGKGKGKGEEDADAAAGLLRRSGEKVGGTIAESEFVAMRNAVLANLDVAHFNSIHAHQLLGMLIKQHRSATSTSTTTAAAGRMGSPAPSVGGQSARSGSTTTAAAPKAPLGIFSHLATAREEEFVLDPLAIALSRTSLASTTTAVRRTLADANADADSDDEYAADPTSAAYGLKQAQREIEAAPGFAEAQLREFKVVLETKRKAIANAAELLSSAAGELRAGQGANRERWRALIGLHARGWRMTPGRPLLDVERFGVSTGEEEEVDVDEGDADKADPAAANGEEAGEAKTAKGGKKQGGEKKTTAAAGLQGFGTPIITSDGKVKEEGARDAWIGFGLPEAPIELRRRSLAYWADSASSSTNTTADEIKHKLVFPDRMHRRLRVRFVLWPPSSSGPEQQQKDEKRLEWCSDPTSSSGTTGKEDGPVVVGAVLDEELQDASREATDELVFGDVVAQARKLPPSFGVRLTATSVRIVLTKRLDLVVELVATSSSASETEAPRYAPHAALLLAFLRMGPLRKYQAFALAVDLARRSDAPARAAALKAAALGAPKKSTANASTGTSAKGGIAAGGTATSHALRRLDTLGPVLVGLHYCSFVHRLGSMLSHVQQRASHTDSRVTVHLVPLDTGASPAHLTHALSRIVDGVASASTQAPAADTLHGHARVYVQAGGQARRLLCTLTFAQPSVLSVQFAAGARGGSAQSRVRLTTKPLAVDVDTLRALLVQQLEL
Length853
PositionHead
OrganismSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Sporisorium.
Aromaticity0.04
Grand average of hydropathy-0.345
Instability index43.98
Isoelectric point6.63
Molecular weight90241.95
Publications
PubMed=21148393

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26724
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.29|      21|      22|     194|     214|       1
---------------------------------------------------------------------------
  194-  214 (39.03/20.34)	RSAT......STSTTTAAAGRMGSPAP
  219-  235 (31.09/14.60)	QSAR......SGSTTTAAAPK....AP
  415-  441 (28.17/12.49)	KTAKggkkqgGEKKTTAAAGLQGFGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     389.81|     119|     316|     240|     366|       2
---------------------------------------------------------------------------
   18-  149 (164.64/75.19)	KEVQLSVEPVHIYTDPDPYPSNSTGAAHTILDAfererklqDITADGTNVFATrKPASVQLG..EDVRRLWAERGdfsrFRTSQLMRGK..REREQESVASSSDDDEEDGADMEGkGKGKGEEDAD.......AAAGLLRRsG
  246-  366 (188.06/100.14)	REEEFVLDPLAIALSRTSLASTTTAVRRTLADA........NADADSDDEYAA.DPTSAAYGlkQAQREIEAAPG....FAEAQLREFKVVLETKRKAIANAAELLSSAAGELRA.GQGANRERWR.......ALIGLHAR.G
  660-  717 (37.11/10.64)	........................................................................APA....RA.AALK..AAALGAPKKSTANAS.TGTSAKGGIAA.GGTATSHALRrldtlgpVLVGLH....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.87|      13|      20|     508|     520|       3
---------------------------------------------------------------------------
  508-  520 (26.22/18.66)	RVRFVLWPPSSSG
  530-  542 (26.66/19.12)	RLEWCSDPTSSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.75|      20|      20|     738|     757|       4
---------------------------------------------------------------------------
  738-  757 (34.55/23.13)	HTDSRVTVHLVPLDTGASPA
  761-  780 (32.20/20.98)	HALSRIVDGVASASTQAPAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26724 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLDVERFGVSTGEEEEVDVDEGDADKADPAAANGEEAGEAKTAKGGKKQGGEKKTTAAAGLQGFGTPIITSDG
2) LWPPSSSGPEQQQKDEKRLEWCSDPTSSSGTTGKEDG
3) MLIKQHRSATSTSTTTAAAGRMGSPAPSVGGQSARSGSTTTAA
4) MSRSTDAGPSTVPAAPPKEVQLSVEPVHIYTDPDPYPSNSTGAAHTILDAFERERK
5) RTSQLMRGKREREQESVASSSDDDEEDGADMEGKGKGKGEEDADAAAGLLRRSG
375
513
188
1
96
447
549
230
56
149










Molecular Recognition Features






MoRF SequenceStartStop




1) HKLVFPDRMHRRLRVRFVLW
2) HTILDAFER
3) KEVQLSVEPVHIYTD
495
45
18
514
53
32