Description | Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MASAPIASASEQPSTSTNPQLGPEPYFAYPTPTPEQLEEELPPYFENENVPLGLVLDRFARKGNHDLRVLLGEVLPQLSIRERPKPIIEYAKTTRQALLKYLAVLRWKTSVDIASTSAGSSVTNTAGPASFPTPHSNNDPNDDSPDAFAGKGKGKTQVDELVIKGKVTDAKRIAHFMEHQNQQHEVAIEHVKHVTKLVEGLRERNPDLLTALSLLSTGTYNRLPTSLVDPYLPKPVLTNSAILKVLRRLNRQIRYRLRCLDYVPPELIVEDIKDGRMYARGDGWRAELTVVGFEDTSRWWLAGVEWGWKAKEKGVDDPGGRVIKKFTGEERQGILDIANGEVLPPRELPDEKSEMEVDTVVTEEPQVKKSELVEVVKKTVDAPLVRVYNFLQHLSLSYQLEVLFTQAIALSQSKWRGQLIPEMDRENKTLRLKYWLRERPVQVQRQDSTSNKRSQAPTTLATSRQLMVGGIIHIGLAETTTPRSELDNLLCDIACGGLAPSERVLKLELGVKWVVDEAGVGGGLKVDDVMDNSVLHLDPDALSAEDLLHICTRTHASHLTRSHGTSLLTSPRFLNASSVQPSLQESTDPSARPLTLRVPLPSRYAVSHLLIGVSPFSGLLEVEDEGAKGNDARAERAAMSMKSVNEGKTKLVDDITRLTTAIVVENIEAQMRQLGWKPTRQIALRLKDLIKADLHPITTVFIPLASSPNHYFVAKAVQNGIVFELLKVAKVPNENGLGMRYMVGDRTMMDLGKLRARRKGGDDKPQRFEVDNKDLKGLFILSNALVAQTIVEQQLKDRSILYTQQFPPTAGPASPKSTSPLAGMVPTICVDVRDLLRAGRGGRSAAMEVAMPKVWLQIEGWWEGGKCEVVTIVVLRHQPSTVAPQTASQEGKSKTDSAESVNAEGISFDPKSSVVRFRAKDISRCVPAFLEQWERLSKVIAVAGEVSLLNKMESFKDVKMLSFDLRTAVLQYAPGYNASVTYSPTDDSYRITFFLSSTSSDTDRNPHELLAPLLSAKLNELTSTDIAGKNKAKGQVGREFMGLLKNTLPVLKLGKTLDIEKGWSMVILGVAKYRLVKDHDGKRFAVDVTLLPDLEHYLIQDGATPRGPDHVVDVYTGPLTSLEMDKVVRAVFDSERIIPAETADDEKMQGKNRLEPPVMKLDQGKSLVCEVERSERMLRKVMEEASKVMGLGNNMEMDS |
Length | 1199 |
Position | Tail |
Organism | Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus gattii species complex. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.332 |
Instability index | 38.56 |
Isoelectric point | 6.93 |
Molecular weight | 132875.72 |
Publications | PubMed=21304167 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26718 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 165.15| 68| 563| 5| 114| 1 --------------------------------------------------------------------------- 14- 54 (27.79/33.30) .................................................................STSTNPQlGPEpyfAYPTP.TPEQLEEELPPYF................................enenvPLGL 55- 148 (85.47/77.87) VLDRFARKGNHDLRVLlgEVLPQLSIRERPKPIIEYAKttrqallkylavlrwktsvdiastsagSSVTNTA.GPA...SFPTPhSNNDPNDDSPDAF......................................... 245- 321 (51.90/24.25) VLRRLNRQIRYRLRCL..DYVPPELIVEDIKDGRMYAR............................................................gdgwraeltvvgfedtsrwwlagvewgwkakekgvddPGGR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 226.34| 75| 105| 980| 1060| 3 --------------------------------------------------------------------------- 980- 1060 (118.56/92.50) VTYSPTDDSYRItfflssTSSDTDRNPHELL....APLLSAKLNELTSTDIAGKNKAKGQVGREFMGLLKNTL..PVLKL..GKTL..DIE 1088- 1172 (107.78/71.51) VTLLPDLEHYLI......QDGATPRGPDHVVdvytGPLTSLEMDKVVRAVFDSERIIPAETADDEKMQGKNRLepPVMKLdqGKSLvcEVE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EEELPP 2) ITFFL 3) QLGPEPYFAYPTPT | 38 991 20 | 43 995 33 |
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