<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26716

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNGSSEQRSSSKIAFEDLRLSVDPTTISLALGEKPVKSIEGDGTLVYDEHKMPDAKFTEQLERIWNEYPSGLLEVTEQKLERLPPNANANKPQEEGVDEAKKRDPFSMMTYEEMEKLRSEIFLQLNDARNELWFVLELAKTLSLSSSFATQPPPPPTALHQKKGKAKPAPPALATLPSIPGEPPILPPGTFSTTLSEFPAKPLHAQIYELEQLLLAKQIALNESQGLIDGAVGELRLMAHAGDRFWKDIRNLKEGEGGRGKWAVVPKPDFGRVGGKGEKAKDVIIPYAIDEAPSGTRARCLAGFDLDPTKKNGLTFGDRHHLRLRATLRDDSGSIISSTPAEVEDQSDVRAMMDAAQMEAFDEDLFNEIRFVAARIPKSETEPQCVSFPVADQVLSFELYNTRSPPSSSISPICDVIISSIRLSLLNIHRQRKINLVAPSQNLTSPVPSILQPIIDTLRFRQLCSVVSWTLNEFNKTLRNARLDSRIQKELLKDGQDDVNEMREVLLGKRGVEVLTGKYSLGIDDSYAIIVGVSAPYSTTVHLSSISFPLANPDELSQVVSDDLSIQLLRLAARHLHGKLGDEHKDGLYCDTLEEVIRIGEIALLRLSIPAPFHAICGSVESERISVPAYDSRQSGVGIFAWLDTVTQSIENSLSSSGSATRIS
Length664
PositionHead
OrganismCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus gattii species complex.
Aromaticity0.06
Grand average of hydropathy-0.306
Instability index50.08
Isoelectric point5.32
Molecular weight73172.27
Publications
PubMed=21304167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26716
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.49|      17|      32|     364|     385|       2
---------------------------------------------------------------------------
  364-  385 (25.43/27.52)	DLFNeirfvAARIPKSETEPQC
  398-  414 (32.07/20.23)	ELYN.....TRSPPSSSISPIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.86|      15|      15|     246|     260|       3
---------------------------------------------------------------------------
  246-  260 (27.84/15.99)	WKDIRNLKEGE.GGRG
  262-  277 (24.02/12.85)	WAVVPKPDFGRvGGKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      14|      18|     170|     183|       4
---------------------------------------------------------------------------
  170-  183 (27.31/14.09)	PPAL..ATLPSIPGEP
  187-  202 (22.70/10.58)	PPGTfsTTLSEFPAKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      15|     531|      48|      64|       6
---------------------------------------------------------------------------
   48-   64 (22.00/21.60)	DEHKmpDAKFTEQLERI
  582-  596 (28.48/18.73)	DEHK..DGLYCDTLEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.98|      18|      18|     442|     459|       7
---------------------------------------------------------------------------
  442-  459 (31.33/16.84)	NLTSPVPSILQPIIDTLR
  462-  479 (32.65/17.79)	QLCSVVSWTLNEFNKTLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26716 with Med17 domain of Kingdom Fungi
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