<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26714

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPDILNQSPATPSSALHATHVLHLPKDRIYIHRYALSAAPGASIKDVVEDKLEKFWRDIADRAENGKGMLETPVAAIVGQIERELWCFTCKDDGIWPPDGINEIQPPLPPLVPLDLLSCPDHSSSYKCLSESSCDVTLNLEGETGKAWGLLANALIETLAWKAGSRIILRDSGVVPFTPPFKPSLYPFTSSSLLLSLLPSPSPTSSSPLYPTATHTLLPLSLPSVLVSTALTPTPAQIARLNQTFDTLLGPAWKTGREQRVAREFVFGSDVEAETISEMQEKGGEEEGWGVFWVPLLKKGSESEEKGVLTVWPVHLALPRLSDASTPNFSLGHNNSSATTTPLPSTQLKQFGGREEREQGLMQIAHSLFDFFTSYREPSVPPEGDGGQVDDQDPDHDNEAGLVDNDAEMNETDGEGSNLRETGADARSDIKMEPSPKEGSDIDDLFSSPSPTSTPIVNMSSQSQSNKSPQPQQVQDQSNNVQNGEVDFMSSLVSVQDPSPPSRSQMMRIRDREREREVEVEITEDDFAFFDSPVPEEGDGIGMDVDMRMDGGVNQSLLDGAVDHRGETGEEPLIEQGKGILTEEMMKPASPKSAMAGQGDLMLVPLVRNDMEVDGILPEPLPLPPVKTATKESPSSQPPVPFQPPTPPTILKASPKAPEQLVSQSPNLTSPSIPLVHAVASNNSLVPLSFQPLPLLPSSHSSSSYPYGNTYGYAPPSPASTPESSILARLASYQTQYQTRPGFEAPFASQDQEATGRLSSKRKSTYADAWFPLSGGNDDGDGEDGEENDMDSQAYTCPPTPISQMEEMATEVESDAGLGGTGGVTGIDVDSRATGLTGMKDQERDSKEDDGEIEWKGVKCIGSEWVVLRDQPGLVQVKKNTESEIGWKVESVWDEAWGTLPSAVSGKNDNVKAKEKLKEKEVKDVNWTKVVQEIITNRALRKSVLDSEDEHEQSAAWMGSLLEGDPLCEVFGTDVLPVNLPQPQVNAASPSTPHIIRLSIAALSYWSQLGLEPQGGKKDVKIFIVCRDSDEALGKMLGEGVKLSWEEERFGKAEFSGIVKGKMEDFGELATGITDQSNGSVNTIVNTIVCLLTPPSQIPLNIYSSPVPNSPNTLFIPVPTPTNPSISFVHEQYLILGHTAYDRLPTLLRPVYVRGEPLRVSEEDEWMQCPAWVLARKEAVKPEFVMTWPVDEYDVLNRWRMWHICYDVVSSSSPGPDAVVVWVGDDRGETGHVRVFEDVGGWKEGMEMICAYGREIAGRWNLEWRLSVCRAGIMAKEELQAWKDILKGKTWPITLLTSETPSPLNPSDQMTPPKVRTIANIGPSILSDSSTRIIDIALSAQLTILPLPLPLELSSDKGSPQTIYPRRTFLLTTHALSVSQHYTTKYHILSHQAPDGRKNQEDGGIVAEIAEEYHRLGCLARERWEGQGWLDTVRWGKALLEKR
Length1443
PositionKinase
OrganismCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus gattii species complex.
Aromaticity0.06
Grand average of hydropathy-0.437
Instability index55.59
Isoelectric point4.69
Molecular weight158005.59
Publications
PubMed=21304167

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1064.89|     337|     394|     219|     612|       1
---------------------------------------------------------------------------
  219-  588 (522.67/325.75)	PLSLPSVLVSTALTPTP.AQIARLN...QTFDTLLGPAWKTGREQRVAREFVFGSDVEAETISEMQEKG....GEEEGWGVFW..VPLLKKGSESEEKG.................VLTVWpVHLALPRlSDASTPNFS.LGHNNSSATT.TPLPSTQlKQFGGREEREQGlmQIAHSLFdffTSYREPSVPPEG...DGGQVDDQDPDHDNEAGL.....VDNDAEMN...ETD.GEGSNLRETGADARSDIK....MEPSPKEGSDiDDlfsspsptsTPI....VNMSSQSQSNKSPQPQQVQDQSNNvqNGEVDFmsSLVSVQD......PSPPS.RSQMMRIRDREREREV.EVEITEDDFAFFDSPVPEEGdGIGMDVDMRMDGGVNQSLLDGavdhrgetgeEPLIEQ.GKGILTEEMMKP
  620-  983 (484.79/220.93)	PLPLPPVKTATKESPSSqPPVPFQP...PTPPTILKASPKAP.EQLVSQ....SPNLTSPSIPLVHAVA....SNNSLVPLSFqpLPLLPSSHSSSSYP.................YGNTY..GYAPP..SPASTPESSiLARLASYQTQyQTRPGFE.APFASQDQEATG..RLSSKRK...STYADAWFPLSGgndDGDGEDGEENDMDSQAYTcpptpISQMEEMAtevESDaGLGGTGGVTGIDVDSRATgltgMKDQERDSKE.DD.........GEIewkgVKCIGSEWVVLRDQPGLVQVKKNT..ESEIGW..KVESVWDeawgtlPSAVSgKNDNVKAKEKLKEKEVkDVNWTKVVQEIITNRALRKS.VLDSEDEHEQSAAWMGSLLEG..........DPLCEVfGTDVLPVNLPQP
  985- 1119 (57.44/ 9.61)	........VNAA.SPST.PHIIRLSiaaLSYWSQLGLEPQGGKKD..VKIFIVCRDSD.EALGKMLGEGvklsWEEERFGKAE..FSGIVKG.KMEDFGelatgitdqsngsvntiVNTI..VCLLTPP.SQIPLNIYS.SPVPNSPNTLfIPVP.................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.65|      12|      21|     176|     187|       2
---------------------------------------------------------------------------
  176-  187 (26.57/13.50)	PFTPPFKPS.LYP
  199-  211 (20.08/ 8.08)	PSPSPTSSSpLYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.77|      22|      91|    1188|    1216|       3
---------------------------------------------------------------------------
 1188- 1216 (31.37/43.26)	WPvdeyDVLnRWRMWHIcyDVVSSSSPGP
 1282- 1303 (42.40/27.05)	WK....DIL.KGKTWPI..TLLTSETPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      11|     251|    1132|    1142|       9
---------------------------------------------------------------------------
 1132- 1142 (21.62/14.51)	QYLILGHTAYD
 1385- 1395 (22.30/15.21)	KYHILSHQAPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26714 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AWFPLSGGNDDGDGEDGEENDMDSQAYTCPPTPISQMEEMATEVESDAGLGGTGGVTGIDVDSRATGLTGMKDQERDSKEDDGEIE
2) DASTPNFSLGHNNSSATTTPLPSTQLKQFGGREEREQG
3) FTSYREPSVPPEGDGGQVDDQDPDHDNEAGLVDNDAEMNETDGEGSNLRETGADARSDIKMEPSPKEGSDIDDLFSSPSPTSTPIVNMSSQSQSNKSPQPQQVQDQSNNVQNGEVDFMSSLVSVQDPSPPSRSQMMRIRDREREREVEVEITEDDFAFFDSPVPEEGDGIGMDVDMRMDGGVNQSLLDGAVDHRGETGEEPLIEQGKGILTEEMMKPASPKSAMAGQGDLMLVP
4) SYPYGNTYGYAPPSPASTPESSILARLASY
5) VDGILPEPLPLPPVKTATKESPSSQPPVPFQPPTPPTILKASPKAPEQLVSQSPNLTSPSIPLV
769
323
372
704
613
854
360
605
733
676










Molecular Recognition Features






MoRF SequenceStartStop




NANANA