<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26713

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMAQATPRSHPPPYSLLQNLTTQSLLLSHLFTLIASPPNPNTSTQTQLTQVYSALQLSTLDLSGLVREVGQHQEAYRRLVEKKKEVAGLEMRVRGLVKRLEEGRKELEGMIDQGEKSLEDIEKSEREPLPAKTLMAHAQSLSKHSSAPVSSLLAPVDKAQYAPWPTEMSMRMGLLFQLEGSMSGMGERGVVGEEQKAPQKVEGRREHVEHEESGRRYDPNAIFQLDLNSDGSDED
Length234
PositionMiddle
OrganismCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus gattii species complex.
Aromaticity0.04
Grand average of hydropathy-0.658
Instability index50.08
Isoelectric point5.58
Molecular weight26054.12
Publications
PubMed=21304167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.36|      13|      16|      97|     109|       1
---------------------------------------------------------------------------
   84-  104 (14.44/ 6.34)	EVAGLemrvrglvKRLEEGRK
  105-  122 (14.91/ 6.76)	ELEGM...idqgeKSLEDIEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.42|      23|      86|      37|      74|       2
---------------------------------------------------------------------------
   10-   35 (32.90/14.69)	PPP...........YSLLQnLTTqsLLLSHLFTLIAS
   37-   70 (33.51/46.03)	PNPntstqtqltqvYSALQ.LST..LDLSGLVREVGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.51|      13|      16|     123|     135|       3
---------------------------------------------------------------------------
  123-  135 (21.26/12.33)	SEREPLPAKTLMA
  141-  153 (18.66/10.00)	SKHSSAPVSSLLA
  158-  169 (17.59/ 9.04)	AQYAPWPTEMSM.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26713 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RKELEGMIDQGEKSLEDIEKSEREPLPAKTLMAHAQSLSKHSSAPVS
2) SGMGERGVVGEEQKAPQKVEGRREHVEHEESGRRYDPNAIFQLDLNSDGSDED
103
182
149
234










Molecular Recognition Features






MoRF SequenceStartStop




1) RRYDPNAIFQLDLNSD
214
229