<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26712
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MLSSPSIPQLVSIAYAQALPPPPHDLRPMCYFPRKPLLTLIFISCAFLDHLLPVPPSIMLAYLAHALSASIITTKDFTIDLLFYISGHEIPPIESLVSIINVLMENPTCFGDGTVLPSMLSDPALVQGDTADGSSKCQNNNQTSTLSLLLPLLRVSATPSSPPTLTAFIARLLTCLSPFPVPPLDVGLEAGQLLPSFTDAIGIPLRNCLGGLMAEATTGDPRQVGQVVYQEDSQLAQGHSSSNVETSANPPLPLKAIVAFLLEQAHRASQWNPHELSLEIEHYQTPAPSYIRLIKAGKHICSDPEEFVVALFEVSIERLISENGGRLIGKAEGIRDWGWVTESLPSLLRWWRLQKEEDGFVGWQLPPVVAEPLTKTVQTFLPDMQNYSEKVLETYEMIVQSAEIEEESSGFTPPEAWQLMTLQEYLIGKLIEMDLITSDEACRMIPTILVPQTVHGQSLLERMESESRAHVKPLVFIISYAFGAAKSFAYEIVKIIKSSPQVPPPENLFLHISHQPSIFSALATFISPSSLYTLMSDRLLEAYSELDEFARSDDPQGYLTRFGEGVILLESFAREFNLDLPELLVNGRRATGYGLLNAEQKDCLNGWVKAIFGSDGIEDQILLATPPQTLCCLVPTLIQQAIAAVACSQIDLDTLHSGLSYFSQPLLSWCLGGVIGWLCDEILRQGALSALHLVVLQALAMSHACPEQLLRVNDRALRNLFSPLSGLDEVIRTSNFDMFAFKAKLESLGIATSHYAPLNQPSVKSSLQSIYSSSLATAFWANPLLDSLWAAADTSNWMTDVLKIIFSQLAKLPVSPVRSAYQRSEEAYVNFVPFLLMVDIKGNEPLLSGLAAWLKNSTEDLIHYTLGSRVLAGIFAQCTLLADTIWGRVMARRVIKELVVELQSLTSLGFRSDEQSEGTTQFHDRKMKHRDERRLTSEQRLICEDIIRMLSHDDGLRARWGNQLAD |
Length | 966 |
Position | Tail |
Organism | Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes>
Tremellales> Cryptococcaceae> Cryptococcus>
Cryptococcus gattii species complex.
|
Aromaticity | 0.08 |
Grand average of hydropathy | 0.087 |
Instability index | 54.85 |
Isoelectric point | 5.01 |
Molecular weight | 106788.64 |
Publications | PubMed=21304167
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26712
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 259.87| 85| 120| 652| 741| 2
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652- 741 (131.28/109.35) LDTLHS...GLSYFSQPLLS..WCLGGVIGWLcDEILRQgALSALHLVVLQALAMSHACPEQ........LLRVNDRALRNLfspLSGLDEVIRTSNFDMFAF
767- 864 (128.59/87.85) LQSIYSsslATAFWANPLLDslWAAADTSNWM.TDVLKI.IFSQLAKLPVSPVRSAYQRSEEayvnfvpfLLMVDIKGNEPL...LSGLAAWLKNSTEDLIHY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 95.12| 20| 141| 18| 37| 3
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18- 37 (43.26/24.02) ALPPPPHDLRPM......CY..FPRKPL
157- 184 (30.39/14.62) ATPSSPPTLTAFiarlltCLspFPVPPL
624- 635 (21.47/ 8.11) ATP..PQTLC........CL..VP....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.29| 35| 52| 534| 569| 6
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534- 569 (55.89/44.60) LMSDRLLEAYSELDEfARSDDPQGYL.TRFG....EGVILL
584- 623 (52.41/36.03) LVNGRRATGYGLLNA.EQKDCLNGWVkAIFGsdgiEDQILL
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