<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26712

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLSSPSIPQLVSIAYAQALPPPPHDLRPMCYFPRKPLLTLIFISCAFLDHLLPVPPSIMLAYLAHALSASIITTKDFTIDLLFYISGHEIPPIESLVSIINVLMENPTCFGDGTVLPSMLSDPALVQGDTADGSSKCQNNNQTSTLSLLLPLLRVSATPSSPPTLTAFIARLLTCLSPFPVPPLDVGLEAGQLLPSFTDAIGIPLRNCLGGLMAEATTGDPRQVGQVVYQEDSQLAQGHSSSNVETSANPPLPLKAIVAFLLEQAHRASQWNPHELSLEIEHYQTPAPSYIRLIKAGKHICSDPEEFVVALFEVSIERLISENGGRLIGKAEGIRDWGWVTESLPSLLRWWRLQKEEDGFVGWQLPPVVAEPLTKTVQTFLPDMQNYSEKVLETYEMIVQSAEIEEESSGFTPPEAWQLMTLQEYLIGKLIEMDLITSDEACRMIPTILVPQTVHGQSLLERMESESRAHVKPLVFIISYAFGAAKSFAYEIVKIIKSSPQVPPPENLFLHISHQPSIFSALATFISPSSLYTLMSDRLLEAYSELDEFARSDDPQGYLTRFGEGVILLESFAREFNLDLPELLVNGRRATGYGLLNAEQKDCLNGWVKAIFGSDGIEDQILLATPPQTLCCLVPTLIQQAIAAVACSQIDLDTLHSGLSYFSQPLLSWCLGGVIGWLCDEILRQGALSALHLVVLQALAMSHACPEQLLRVNDRALRNLFSPLSGLDEVIRTSNFDMFAFKAKLESLGIATSHYAPLNQPSVKSSLQSIYSSSLATAFWANPLLDSLWAAADTSNWMTDVLKIIFSQLAKLPVSPVRSAYQRSEEAYVNFVPFLLMVDIKGNEPLLSGLAAWLKNSTEDLIHYTLGSRVLAGIFAQCTLLADTIWGRVMARRVIKELVVELQSLTSLGFRSDEQSEGTTQFHDRKMKHRDERRLTSEQRLICEDIIRMLSHDDGLRARWGNQLAD
Length966
PositionTail
OrganismCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus gattii species complex.
Aromaticity0.08
Grand average of hydropathy0.087
Instability index54.85
Isoelectric point5.01
Molecular weight106788.64
Publications
PubMed=21304167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26712
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.87|      85|     120|     652|     741|       2
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  652-  741 (131.28/109.35)	LDTLHS...GLSYFSQPLLS..WCLGGVIGWLcDEILRQgALSALHLVVLQALAMSHACPEQ........LLRVNDRALRNLfspLSGLDEVIRTSNFDMFAF
  767-  864 (128.59/87.85)	LQSIYSsslATAFWANPLLDslWAAADTSNWM.TDVLKI.IFSQLAKLPVSPVRSAYQRSEEayvnfvpfLLMVDIKGNEPL...LSGLAAWLKNSTEDLIHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.12|      20|     141|      18|      37|       3
---------------------------------------------------------------------------
   18-   37 (43.26/24.02)	ALPPPPHDLRPM......CY..FPRKPL
  157-  184 (30.39/14.62)	ATPSSPPTLTAFiarlltCLspFPVPPL
  624-  635 (21.47/ 8.11)	ATP..PQTLC........CL..VP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.29|      35|      52|     534|     569|       6
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  534-  569 (55.89/44.60)	LMSDRLLEAYSELDEfARSDDPQGYL.TRFG....EGVILL
  584-  623 (52.41/36.03)	LVNGRRATGYGLLNA.EQKDCLNGWVkAIFGsdgiEDQILL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26712 with Med5 domain of Kingdom Fungi
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