<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26698

Description Cyclin-C (Fragment)
SequenceMAGNFWQSSHYPKRRDHFALLKSLEQSWSFLSGKGNECGRQDNSGKTNEKIMKGHCLSLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLEL
Length192
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.14
Grand average of hydropathy-0.293
Instability index49.22
Isoelectric point9.21
Molecular weight22493.78
Publications
PubMed=14574404
PubMed=19369195

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26698
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.41|      31|      46|      89|     121|       1
---------------------------------------------------------------------------
   89-  121 (49.16/39.19)	IFFTNVIQALGEHLKLRqqVIATATVYFK.RF.YA
  138-  170 (42.25/27.20)	VFLASKVEEFGVVSNTR..LIAAATSVLKtRFsYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.10|      17|      46|      16|      32|       2
---------------------------------------------------------------------------
   16-   32 (30.54/19.91)	DHFALLKSLEQSWSFLS
   64-   80 (28.56/18.21)	DKQDLLKERQKDLKFLS
---------------------------------------------------------------------------











Associated diseases
Disease
colon cancer	PMID:21806996
cancer	PMID:32463833
colorectal cancers	PMID:32206448
Gastric cancer	PMID:32206448
obesity and metabolic diseases	PMID:28351837 PMID:30352217



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26698 with CycC domain of Kingdom Metazoa
Unable to open file!