<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26695

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESMEKDWKLCLDGCLDRRISKTVFAALVAELHARSPLPGRRIAALLLRPRSAGANSVDPRVLIYIEQLLASRIVNAADVLISTFRYSKDRLPKTGQSPKEPQWHNPPELEENLFHRLSKAFASEERPLTNSEGIATLMIVTRWMQALVTSHTSDTMIQAMSGIQQQPQQQSVSVREGLGVLVVGIIENSRVLHILKHPKGKDLRKSFTQSLSSFVIFLSHNSAGSQNSLHLAERLENSQKQHEFYEKIPTVNGGTNEDSGLGVASLHLDATMDLPVMNTRAGLYIFLNSLLVARPLTDDYTIMSYLHSRYKLETQSMAMATDLITASFDILANAMYRSEPASNMFCLKSFLVNKIPILLSQLSASIFPMTLEMCITQALSHVDPNAFPAFSQGFDDMMGNNTSLSDVRQDFLNACALHSLIPSAAVERLLGETPMQGPPETRYDKKTLLDQCKSNFDKVNTFIDELDNLDGNAGAIVGAVTEFISHLCETQTTMYLKQISCMIFKKPQAMDVMLQFTSPASILQPLSQFLDDWHYDSDQGRPYFEHTREMSADKAGEYQPVFDEFGAILVLIMAFVYRYNLTYRDLGITYGSFIARLIERGHHSLSPDEMTEDQSRSLGIWLKGLYDHDKEGLSNDVFASCRPQDFYLIVPTLFNQTVLACSHGILTFESVKSGLEYLGETFLLPSLIGGLRWMASYALLQTHKDLDAIMRIFKELMLSATSSGDAQAMHSTILAMVSSHLETTFKTIQRREPARTTIEPLLQAIKANSNYERSTYATVKELERWTNAPYSTLGTALGHTVQQLITWSSNAAMQPNPPSYTHLQIYATTRMLGAYKTLRAIVETVTTQTNAGYGSAALDVGMSMICAPTVEDSPIAVDWAGSTVVAPPPQRTRMNLREMLKQEFDNAASLVATEPLTAETIVRLQRRVEAQLGAMNDASLQARTLNLPSVHITEMQSQTISDDINKAMDDAAAATMVDDISNMDNKALQRSMEELAGTDSLHLSGMGMGAGSANGVDMSAELGHLDLVDMGSMGMDMDVGNMDMGGGGDDDWGLDFENM
Length1060
PositionTail
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.07
Grand average of hydropathy-0.156
Instability index45.97
Isoelectric point5.20
Molecular weight117321.45
Publications
PubMed=21326234

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26695
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      24|      25|     995|    1019|       1
---------------------------------------------------------------------------
  995- 1019 (38.69/25.77)	ELAGTDSLHLSGMGMGAGSANgVDM
 1022- 1045 (45.92/26.21)	ELGHLDLVDMGSMGMDMDVGN.MDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.37|      14|      25|     779|     792|       2
---------------------------------------------------------------------------
  779-  792 (27.73/16.98)	TVKELERW.TNA.....PYS
  801-  820 (17.65/ 8.26)	TVQQLITWsSNAamqpnPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.86|      25|      25|     294|     318|       3
---------------------------------------------------------------------------
  272-  291 (26.12/12.92)	.....TMDLPVMNTRAGLY.IFLNS.L
  294-  318 (43.47/26.39)	ARPL.TDDYTIMSYLHSRYKLETQS.M
  321-  345 (28.27/14.59)	ATDLiTASFDILA..NAMYRSEPASnM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.47|      12|      18|     858|     869|       5
---------------------------------------------------------------------------
  858-  869 (23.21/16.12)	ALDVGMSMICAP
  877-  888 (22.26/15.13)	AVDWAGSTVVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.46|      58|     401|     185|     251|       7
---------------------------------------------------------------------------
  185-  251 (90.59/69.11)	GIIENS...RVLHILKHPKGKDlrkSFTQSLS.SFVIFL....SHNSAGSQNSLHlaerleNSQKQHEFYEKIPT
  588-  653 (90.87/52.24)	GITYGSfiaRLIERGHHSLSPD...EMTEDQSrSLGIWLkglyDHDKEGLSNDVF......ASCRPQDFYLIVPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.73|      11|      16|     675|     685|       9
---------------------------------------------------------------------------
  675-  685 (19.12/11.67)	GLEYLGETFLL
  691-  701 (20.61/13.19)	GLRWMASYALL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26695 with Med5 domain of Kingdom Fungi
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