<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26694

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMVSLLKRPSGASRLEWQKFLQQCVLQRISTNEFHELAKVMLRRHPVPHMDLFNIILESRAVTDFDWDPLIPDYVDAVQKLTQVDLFTILPSLLAHSSIKADIRRWKKQNHTQNHDEKPKIDEKGPTEPAGSQGPATLLTDYGIMQNVITAVTTGHSPKTALGFMDTCSAIADWILALVSWNAHLGSEKGEGSGTQLLGTPDVVSIFIAVGFLFGALAGTEVGANALSFQHAETFKHQRTKLARALTAYSPICAEISIPLRNRLDQLQKEFNIFLKDEKSNQDHVIEDTTVSTMEFESRVVDIPPVSSRAGLYIYVNSLLVGRPLIDDNLLINYLNNRYGGNHMALVEELITASFDVLSNGMYRNEPQQTMFLFRAFLVNKLPPFLSDLAGSVVEPIPVELCITRALARVDPNTFPSFSEIFSTHGNSVLSDVRQEFLFSCALHKLIPESSIERLLGENPMQTLPNGGRFIKHDLVSQINNNHERAEQLLNGIESMDGNARAIVEAIAEVMHNMCLRKDTMTLKSLCNSLSRRPQALDIMLLFKSPQAILQPLCALLDSWKWDEDQVESQPVYDEFGSVLLLVLAFKYKYDLSYQDLGVFNPDSFMCRLLEKGASSQKLEDLTEKQQQNLGAWITALFIAEGISDESMSSCSPQEFYLLVATLFCQSLSACEAGKLEFDTLKGGFELHWINGLEDLLEPFLLPSLVMALSWIGKHIWKSGTDLTTTLRLLATLVKPTSISGEAQEIHRTVLSITARALADELRTAKTRHPSRTDIDPILQALEPYQSFQRTGTSNRAELEGWRSSSAPGGMVTGIRNTFSSLVLWSTDPEISMTPPSYTHRQLLAGLKHLGSVRVLVGILEELKLQSETGSGDLAIDIAATLICAPMGECFSWEQATYQSVGGTLKDSLPRSQMLNLRDALNLQRESLAKMIESEPHRAELVIRLARRVDALTSIPQIPQAVDNIDVGNIMADMDLTGVEEDGQMQLDVGQQAEQQGQQQQNLATTGTDATHGTLDAILDAATAEGVTGPPAGSDVTMAQPDIDASIFDDMLNPTDMGVGNPEFIDLDMEGMF
Length1072
PositionTail
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.07
Grand average of hydropathy-0.117
Instability index42.83
Isoelectric point4.92
Molecular weight118551.79
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26694
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.67|      89|     459|     455|     602|       3
---------------------------------------------------------------------------
   89-  180 (147.23/70.84)	LPSllAHSSIKADIRRWKKQNHTQNHDEKPKIDEKGPTEPAGSQGPATLLTDYGIMQNVITAVTTGHS....PKtALGFM...DTCSAIADWILALV.SW
  463-  559 (138.44/168.22)	LPN..GGRFIKHDLVSQINNNHERAEQLLNGIESMDGNARAIVEAIAEVMHNMCLRKDTMTLKSLCNSlsrrPQ.ALDIMllfKSPQAILQPLCALLdSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      14|      21|     645|     658|       4
---------------------------------------------------------------------------
  645-  658 (26.99/17.26)	ESMSSCSPQ..EFYLL
  665-  680 (20.39/11.15)	QSLSACEAGklEFDTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.52|      18|      21|     790|     807|       6
---------------------------------------------------------------------------
  766-  783 (28.15/16.98)	TRHPSR.TDIDPILQALEP
  790-  807 (30.74/19.26)	TGTSNR.AELEGWRSSSAP
  812-  828 (22.64/12.13)	TGIRNTfSSLVLW..STDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.21|      19|      28|     560|     580|       7
---------------------------------------------------------------------------
  560-  580 (30.54/25.86)	KWD...EDQVESQPvyDEFGSVLL
  588-  609 (31.67/19.33)	KYDlsyQDLGVFNP..DSFMCRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26694 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DMDLTGVEEDGQMQLDVGQQAEQQGQQQQNLATTGTDATH
2) TLDAILDAATAEGVTGPPAGSDVTMAQPDIDASIFDDMLNPTDMGVGNPEFID
972
1013
1011
1065










Molecular Recognition Features






MoRF SequenceStartStop




NANANA