<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26691

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVMDDPSAHGGWRTAGTVNGDNAASDNGTFHHTDNNSHANGRANGIKPQSSDLIAAPELPPPEIAHITQGFFPLAKGINRVVVQCWNDLLQLLSELGDAHPNAQGGSSASNASNAKKSQILEFAQAKRAEFIKLLVLSQWGRQAVDVGRLIDLQFFIRQRYDLYNYTLFLAGNIKRDLFKAQMGNPDLETALEALSTGAVSALPALPFLPPGKLSPKDTLKTLRKINKLISIRLITHDSIPDYATYHIHDGRVTFTIPNEIELDLSIAQETRNSQFFFVDLRFIFSPSSALSKGPVRDSLERTINTALMKSGIVGCCDLLHNLVLSQKIMTYFRQAIELARSHWGNNLRIELLHRTLVIQYWTNRPGPKSWIEIGTRRNKPQRRNRANQPDIPRLYVRWIRDNKEVSVTSKQLDGNIISVESILRRTISKHIHDIFFEVYTNLAASKLYGQGALFLGLNTSATEPGNCYLDVHLTRRKTLRLAIEPIGGIVALQTVPLSLNRHDVEPDSSKGLSVGTYERICRLRCLVAMEEAEGHGRVFGWKLIAPANVDMQSLRKVLPVNEIRNISLFQHKDWDPNWLVGFTSSIERDDWWVIRLQNRAEPQIRSPGDGRLIQLQQAHAVTGQCGYASNKHRYRSFAKLANAISGMVVAHSNADCLDTLKLQHSPKIENLVLGADNEVPETSVRFQASDLPGQLRVTSPLSSRGKTIIRDTVYLAYEGINHRTREAIVVATGCFAVPVSHLRMARLASDSNITFKPRSRKFSIRFLTRTGVPIITQVFSWLQQLTNTVLALEYIYRKKFVVTSISSSKISFTYPSSNGDLRASISFQYIDTPTPLLLSGSPQPTAKDDGKPLARLRMSLNLHGKNPHRRIMESLTAILNDPSAGLGFTLEFLTLTLPLLEAVETILAESSDRSRAVVRIAARSAKVYHISYPFLQYRFHLTMKQRRQSTYWLLRNGTMPSVRMSQVALESELTNKILKVNGDGWRGLGDGTMAEADKPVNLVMVLDNIIKTHVAQQRTQPEANGAGRAIMVDKTKREEGSQNSSIPAALSNNSDGTSQPAVAAMSTAGAAAPNSESDSSKQANNGSIITID
Length1096
PositionTail
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.07
Grand average of hydropathy-0.262
Instability index44.74
Isoelectric point9.59
Molecular weight121655.48
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26691
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.61|      70|     185|     720|     794|       1
---------------------------------------------------------------------------
  720-  794 (104.85/86.12)	AYEGI....NHRTREaiVVATGCFAVPVSHLRMARLASDSNITFKPRsRKfSIRFLTRTG.VPII..TQVfSWLQQLTNTVL
  906-  982 (106.76/68.05)	AVETIlaesSDRSRA..VVRIAARSAKVYHISYPFLQYRFHLTMKQR.RQ.STYWLLRNGtMPSVrmSQV.ALESELTNKIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     399.13|     130|     185|     138|     284|       2
---------------------------------------------------------------------------
  138-  284 (187.80/157.86)	LVLSQ....WGRQAVDVGRlidLQFFIRQRYDLYNYTLFLAGNIKRDLFKAQMgnpDLETALEALSTGAVSALPALPFLPPGKL.SPKDTLKTLRKIN.KLISIRLITHDSIpdyaTYHIHDgrVTFtipnEIELDLSiAQETRNSQFFFVDL
  326-  461 (211.33/130.65)	LVLSQkimtYFRQAIELAR...SHWGNNLRIELLHRTLVIQYWTNRPGPKSWI...EIGTRRNKPQRRNRANQPDIPRLYVRWIrDNKEVSVTSKQLDgNIISVESILRRTI....SKHIHD..IFF....EVYTNLA.ASKLYGQGALFLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.81|      21|     972|      96|     116|       3
---------------------------------------------------------------------------
   96-  116 (37.97/23.23)	LSELGDAHPNAQGGSS..ASNAS
 1069- 1091 (32.84/19.06)	MSTAGAAAPNSESDSSkqANNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.04|      28|     185|     465|     500|       4
---------------------------------------------------------------------------
  465-  500 (39.76/44.43)	ATEPGNCyLDvhltrrkTLRLAIEP.IGGIV..ALQTVP
  654-  684 (42.28/25.76)	AHSNADC.LD.......TLKLQHSPkIENLVlgADNEVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.61|      31|     973|      14|      46|       5
---------------------------------------------------------------------------
   14-   46 (54.25/42.01)	GWRTAGtvNG...............DNAASDNGTFHHTDNNSHANGRA
  988- 1033 (47.36/30.08)	GWRGLG..DGtmaeadkpvnlvmvlDNIIKTHVAQQRTQPEANGAGRA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26691 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGIVMDDPSAHGGWRTAGTVNGDNAASDNGTFHHTDNNSHANGRANGIKPQSSDLIA
2) VAQQRTQPEANGAGRAIMVDKTKREEGSQNSSIPAALSNNSDGTSQPAVAAMSTAGAAAPNSESDSSKQANNGSIITID
1
1018
58
1096










Molecular Recognition Features






MoRF SequenceStartStop




1) AVAAMSTA
1065
1072