<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26685

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSSMESLRDVKLRPWPASKQGTLSQQKLYAQIEQLTTERAHLRDITKTALQEALGAGKDIPDGVALKEKEDEEKKEKKEVVTQKVTRETIFNAQREMYSHLEWAKFAATNALDLLSLVLSQDPNKRVASSFSHTFREQGLEQGIPFGSFGISKESHEYFVPRPEEAERLEELAKKQLLVAKGSRMEALDSAADEILKAAKKLEKEVRRETKYWQEIVSVSDKGWPIQRLRQNARHVPFGVRFGLPEASDHFKARGFAPLRMSKDGSIILDPALALKPKTFRVRVTLDGETTGTSQLSVQQDMKDNSIEKSIQLARDSLFEEELYHEMSMETRQLLAYGVEFRDSVIQLDVPRMGNTSQQLKLLIDCIPRDEPIAESQSQSHNWLAQNVAEGLRLLLAHEHSMRLYRRSQVPPPLTARAQEKPPPPLLRTLLAVFRHLESVDSLYVYLETLKRTLDSAGLEMGLETTREVSWAKAAESLKTPKVGLSTSDQLLEIFNKPFDGKASIVLPTASGAPSEILSVVTRTVLAQPIFGTEHKLTLPASLTAELGLSQTIKFSSVDELTSYLDWILSSHIVHRIIKGEYSSRAVIKDEDTNVTILGQVSKKGSSASKKDVSIEVCDGSLKMKVTNLDCSSGSEGNAETSHSWDGSDDSTALKELLRSCVG
Length663
PositionHead
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.06
Grand average of hydropathy-0.432
Instability index43.10
Isoelectric point6.27
Molecular weight73990.30
Publications
PubMed=21326234

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26685
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.56|      20|     119|      65|      89|       1
---------------------------------------------------------------------------
   65-   89 (27.78/31.17)	ALKEKEDE....EKKEKKEvvtqkVTRET
  187-  210 (27.78/18.08)	ALDSAADEilkaAKKLEKE.....VRRET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.59|      60|     223|     239|     298|       2
---------------------------------------------------------------------------
  239-  298 (100.68/67.20)	GVRFGLPEASDHFKARGFAPLRMSKDGSIILDPALALKPKTF..RVRVTLDGETTGTSQ.LSV
  458-  520 (88.91/58.47)	GLEMGLETTREVSWAKAAESLKTPKVGLSTSDQLLEIFNKPFdgKASIVLPTASGAPSEiLSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.74|      24|     206|     135|     185|       3
---------------------------------------------------------------------------
  147-  172 (37.56/62.46)	GSFGISKESHEYfvPRPEEAERLEEL
  634-  657 (42.18/10.90)	GSEGNAETSHSW..DGSDDSTALKEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26685 with Med17 domain of Kingdom Fungi
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