<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26682

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMYYMYNIYARMDWALGAKAGQKVKGLTPRDQTNVPAFKAFALSRLPSAYFPPTFEPGHFSPDDVHSFSFGPAAAATTPFPRHPTPLRLPPPPPPPPHYHYHHHHTTTTTTTANPPPSLTLSAPFQLRRLRLHPSPPSTPQPCDSRPFPPSTHLLPSFTLGDRSKSLYLALRPPSLSPLSFLARGLSILTCPITWPQKRLGILIMDSSSAPNPAAAAREGDSKKRDRDGILLNGDRIEARRDTPAGPSVNARSTQGAGMNGASMAVAGPGGSMPDQYPEQPPEIHHIPSELYNPLSVLLERIAQECYNDLTDLLTNMADLPLAPTSNGALPNGLGSHGQENAEANKRKKLMLLKFAQDNRSKFIKLLVLTEWGKKAAHDVSKLIDLFAWTQEQNAHMECLDEQLQRIKIHSNMARENNPDINTALEILSTAKASWMPALDYLPAEPISSEQALTLLQHMNTSLSIRLNLHENLPRHLRNWRIHSGRATFVIPNEFEFDVISFVEDASSQWSFIDIRLLFSPAPVITVGSPFFMTLKYKADEVLGKSGLSGLFDYLQNFILTHKISVLRSQAVGLVRLGRAASLKVEPVHRELIVQYWMNRPGKKNWIDIGVSHNRPKNGKVSWRGPPLPTLEARWFREGKEVKDAELSLDWSDLSMERIVKQITARHTNDILRATQESIKLKLRVELQTSETEPADCRLRTTLGPKSNSLTMSLEPVTGRYLLRPANATTARAENAFNQGREPAAIGHILTQALAQSLLLSIQSVASQLGWQAVSRRTLQAKVVKEAVNLDVIQYSLYCPRGWSAQWALGAIIDTNGESWWVLELNSTGSAVEYAEEIKMKRPEGSSLSVDRKTLASLARVAVQLISFRVTARQLSKEKKSCSLRYEFARASTSAVTKNVARGWALHIQTSDLIVTRSDEQPWLESTVAVHCEGLRAGGQHVWHIASGRMLPSAAADMQKLMAASPPSTFSFSEDGRFRILLSTPFGHNILDELRARLRDVNRLRSFATTLQKRRMRLGASSLQRVQFEYGPGPLVAAINFASENEFTVEMSPKNPHYRILHLLTAIANDRMPGLPASLEGSDTNGLDRFCTSLMLTRSMLKVLAELETRTPGNVKNPAVHVHSLFKYRLTYENPVCTFDMRLQPKDDSVFWLIEDNYRTRGQETRPSPERTPGHRRLDDLQAKLKELFSTKSTGWFGTRNGMVAELDAVPDALRKLDACVLECTMEGGYKAPPPEQPASQAQMNTAQPGQQHLQNQHAHHQQQQQQQQQQQQQQQQQQQQKQQQQQVNQQRIQQHQHRQQQQQHLHHQQQQQQNHTLALSHAQSQHRKQLQHQSRTHLPNQRPPPPPPQQQLQQHRPAPGSAPPGSALAQPPSRQPGQSKSDVITID
Length1387
PositionTail
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.07
Grand average of hydropathy-0.542
Instability index58.04
Isoelectric point9.53
Molecular weight155322.65
Publications
PubMed=21326234

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26682
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     176.51|      15|      15|    1272|    1286|       1
---------------------------------------------------------------------------
 1240- 1254 (21.41/ 6.13)	QAQMNTAQPGQQHLQ
 1255- 1269 (29.28/10.90)	NQHAHHQQQQQQQQQ
 1272- 1286 (29.71/11.17)	QQQQQQQQQKQQQQQ
 1289- 1303 (26.96/ 9.50)	QQRIQQHQHRQQQQQ
 1304- 1318 (22.33/ 6.69)	HLHHQQQQQQNHTLA
 1319- 1333 (21.91/ 6.44)	LSHAQSQHRKQLQHQ
 1341- 1355 (24.91/ 8.26)	QRPPPPPPQQQLQQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.54|      13|      21|     114|     131|       2
---------------------------------------------------------------------------
  114-  128 (20.38/ 9.22)	PPPSLT.LSapFQLRR
  171-  184 (17.16/ 7.79)	RPPSLSpLS..FLARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.59|      14|      16|     364|     377|       3
---------------------------------------------------------------------------
  347-  360 (20.27/11.13)	KKLMLLKFAQ.DNRS
  364-  377 (22.66/13.40)	KLLVLTEWGK.KAAH
  381-  395 (20.66/11.51)	KLIDLFAWTQeQNAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.24|      20|      21|     903|     922|       4
---------------------------------------------------------------------------
  802-  819 (30.59/19.08)	WSAQWALGAIIDT..NG....ESW
  820-  842 (19.21/ 8.93)	WVLELNSTGSAVEYAEEikmkRP.
  903-  922 (35.43/23.40)	WALHIQTSDLIVTRSDE....QPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.60|      24|      40|      58|      97|       5
---------------------------------------------------------------------------
   67-   97 (39.90/28.70)	FSFGPaaaatTPfPRHPTPLRlPPPPPPPPH
  129-  152 (49.70/13.70)	LRLHP.....SP.PSTPQPCD.SRPFPPSTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.51|      12|      21|     688|     699|       6
---------------------------------------------------------------------------
  688-  699 (21.96/15.40)	TSETEPADCR..LR
  710-  723 (15.55/ 8.38)	TMSLEPVTGRylLR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.26|      28|      40|     396|     426|       7
---------------------------------------------------------------------------
  396-  419 (36.99/20.00)	............MECLDEQLQ.RIKIHSNMARE.NNPD
  423-  450 (18.06/10.42)	ALEIlstakaswMPALD.YLP.AEPISSEQ........
  451-  480 (38.21/17.82)	ALTL........LQHMNTSLSiRLNLHENLPRHlRNWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     189.10|      40|      40|    1036|    1075|       8
---------------------------------------------------------------------------
  962- 1015 (46.58/29.51)	AA...SPpSTFSFSEDGRFRILLSTPFG.....................HNildelrarlrdvnR..........LRSFATTLQKRRM
 1031- 1071 (61.64/41.90)	PG..pLV.AAINFASENEFTVEMSPKNP.....................HY.............R..........ILHLLTAIANDRM
 1072- 1110 (36.29/21.04)	PG...LP.ASL..........EGSDTNG.....................LD.............RfctslmltrsMLKVLAEL.ETRT
 1111- 1171 (44.58/27.87)	PGnvkNP..AVHVHSL..FKYRLTYENPvctfdmrlqpkddsvfwliedNY.............R..........TRGQETRPSPERT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.06|      15|      33|     205|     219|       9
---------------------------------------------------------------------------
  205-  219 (24.41/12.76)	DSSSAPNPAAAAREG
  234-  245 (20.43/ 9.37)	DRIEARRDTPA...G
  246-  260 (25.21/13.44)	PSVNARSTQGAGMNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.82|      10|     184|     990|     999|      10
---------------------------------------------------------------------------
  990-  999 (17.10/13.71)	LDELRARLRD
 1177- 1186 (16.72/13.18)	LDDLQAKLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      18|      42|     272|     294|      11
---------------------------------------------------------------------------
  272-  294 (28.33/26.90)	MPDqYPEQPPEIHHIPselyNPL
  316-  333 (32.92/16.22)	MAD.LPLAPTSNGALP....NGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.16|      29|     103|     520|     548|      12
---------------------------------------------------------------------------
  520-  548 (50.76/29.56)	PAPVITVGSPFFMTLK.YKADEV.LGKSGLS
  624-  654 (43.41/24.23)	GPPLPTLEARWFREGKeVKDAELsLDWSDLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26682 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CTMEGGYKAPPPEQPASQAQMNTAQPGQQHLQNQHAHHQQQQQQQQQQQQQQQQQQQQKQQQQQVNQQRIQQHQHRQQQQQHLHHQQQQQQNHTLALSHAQSQHRKQLQHQSRTHLPNQRPPPPPPQQQLQQHRPAPGSAPPGSALAQPPSRQPGQSKSDVITID
2) DSSSAPNPAAAAREGDSKKRDRDGILLNGDRIEARRDTPAGPSVNARSTQGAGMNGASMAVAGPGGSMPDQYPEQPPEIHH
3) PFPRHPTPLRLPPPPPPPPHYHYHHHHTTTTTTTANPPPSLTLSAPFQLRRLRLHPSPPSTPQPCDSRPFPPSTHLLP
1223
205
78
1387
285
155










Molecular Recognition Features






MoRF SequenceStartStop




NANANA