<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26677

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKSCSTNAQAIGDFEAIAFQAFSVSRTTNQTSSRDREWPASDDIRAVESKLRQASHWVTQDAARPWLWLFRPATVEDSEQAAFELPTVDGYQWQREQGGRIKAVELARPPIRTGQPSPTSGSAAPSTTSAPQKGSQVGGARVAQSHSQANTADQQPPDFFTIYDLLISSVIGLISYTLVKDCKVVALNYRTFISRPSTLNTPQDTHDLSSSDLHWLTSISAHWTSSGTFLVSTLTQGNHSICCLDQIEHASQQEQLIGRVIRVAPNGLLASIVTFDDPLDTIAVETTSRQKKRPRTTTVEQSIAKWKSTVIRWLGWRGFLLPDLEKRESWVRIRTTQATPFSTSSLNSSSHEWDILWPRALCFLYTPDRVEDTMGDPFSTSMSEPRSSVLRWFETASSPGFKDPLDVAQEWALGKADRDKFLEAQRRAKKAEEEAVRRKDEQVGLFPTSPLNTRTGVYGDMQAVGGVYPTPPDGVVPLSGPSHSDTPSVSGAVSNVILAPGGNNPAINLSAPQHHSQTEMREPLTSPAFPAAPDNFNTSNGNDDLFGDMEEEGYEGDNINDEDFDFFDAPDDEDVDMLDAPEMPGSKVASAKEPSTQDAQVAPAPQIKKEEADPSAALEHALATASQSNQSELSTSNKTGQGAPIAADPVNARTTTTREKPIQPPKKDVKTVKRETTSPPITGGTVQIVRLHPNKKVTLQTRKEETSDHSRDRAFDPLHFSRKMSLADAKYEDGRFGVDREKNTIAERRVISRSAESKNLGGIPFMTNLRHAIGAASTARIPEITALARAASEDSDSSSEDSQASEHESTEEPEASPMAFLSSLHMPAKRKLPTDGNATPMSVTSFAESWGGDWHDLQGLQLDEAYLASLEPSSWDWSLVYSSPPSERTVLGARFSMPALPPAMQMPDTPTSQPDLSLEMSDERLLSLKDSIIITQIVTDQIVSTTLDILNEDTPNETKFATPPSLEVRWHSAIKSLFPDAVECTVPALAAVNDVFPDFQAQGKGQQRPPPRKQNEGTTTGCQMFHMNPPFLRVRRADTHWDLLPPAVAFWEHLGLSPASPPKNIVSFCIYPHSESLRPCLEGFLLNLQLAYDSCKLGSHGRIETVVEFEGGLVPCKLTNPTSERDAFRAYKDTCVQLGKLLAMQYPKIQEQQEAKIDAFVIYMVDPFGGPSALWELCQSFWALFQAYGQGPPGRPDQSQKPDLVLQVVPMKYIASFDAPVILDPSTYINLAREVYDRCPPSAPSGDKTCLSIYTAPAFQLEETIPRSIPFKLLSEPPQDLLRENCYMHLGYAVSLDGLWVTAAWTDTCGKSQTVVSYHLGTRMFGEIAKEIWQTTIEILQSRRVHWRVCIAKAGVMDREELETWVLLISYPAQLNLFITLLTVDTDAPFKFTPTVPTSQAQAGTATPGSTPQPTVSPDPTASLTPAATPSSLDPSLDPSQDPDARLIDVTDETWGITLGHRLHNSNSTNHFSPALISGLLVKRGTSFATSHSISHPIPDPEPGPIVIAVNILWIGAVGSNTTPSATNNPSHIPNSNNPNNASTSRTSSPFPASTNPSTDPGTPSSSPASAPPSPSPASEAAGPRSTSSLMWTPTPQTRSTAENLLKEILVPRIR
Length1618
PositionKinase
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.07
Grand average of hydropathy-0.438
Instability index51.55
Isoelectric point5.16
Molecular weight176812.68
Publications
PubMed=21326234

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26677
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1267.90|     310|     317|     675|     989|       1
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  369-  622 (322.49/193.30)	....................................................T..PDRVEDTMGDP.....FSTSMS...........................EpRSS..VLRWFET..ASSPGFkdPLDVAQEWALGK...ADRDKFLEAQRR..AKKAEEEA.VRRKDEQVGLFPTS..................PLNTRTGVYGDMQaVGGVYPTPPDG.VVPLSGPSHS.....D...TPSVSG..AVSNVILA...PGGNNPA....INLSAPQHHsQTEMREPLTSPA.FPA......APDNFN.TSNGNDDLFGDMEEEGYEG..........DNINDEDFdFFDAPDD.EDVDMLDaPEMPG.SKVASakePSTQDAQVAPApqIKKEEADPSAALE
  675-  989 (512.34/326.93)	VK..................RETTSPPITGgtVQIVRLHPNkkvTLQTRKEET..SDHSRDRAFDPLH...FSRKMSLADAKYEDGRF.....GV.DREKNTIAE.RRV..ISRSAES..KNLGGI..PFMTNLRHAIGA...ASTARIPEITAL..ARAASEDSDSSSEDSQASEHEST................EEPEASPMAFLSSLH.MPAKRKLPTDGNATPMSVTSFAESWGGD...WHDLQGL.QLDEAYLASLEPSSWDWS....LVYSSPPSE.RTVLGARFSMPA.LPP......AMQMPD.TPTSQPDLSLEMSDERLLS........LKDSIIITQI.VTDQIVS.TTLDILN.EDTPNETKFAT...PPSLEVRWHSA..IKSLFPDAVECTV
  995- 1312 (332.10/200.68)	VNdvfpdfqaqgkgqqrpppRKQNEGTTTG..CQMFHMNPP...FLRVRRADT....H.WDLLPPAVA...FWEHLGLSPA...............SPPKNIVS...FC..IYPHSESlrPCLEG....FLLNLQLAYDScklGSHGRIETVVEFegGLVPCKLTNPTSERDAFRAYKDTcvqlgkllamqypkiqEQQEAKIDAFV..IY.M....................VDPFGGPsalWELCQSFwALFQAY.GQGPPGRPDQSqkpdLVLQVVPMK.YI...ASFDAPViLDPstyinlAREVYDrCPPSAPS.....GDKTCLSiytapafqLEET..IPRS.IPFKLLSePPQDLLR.ENCYMHLGYAV.....SLDGLWVTA..A...WTDT..C..
 1314- 1459 (100.96/52.64)	.................................................KSQTvvSYHLGTRMFGEIAkeiWQTTIEILQSRRVHWRVciakaGVmDREE...LE.TWVllISYPAQ...LNL......FITLLTVDTDA.pfKFTPTVP..TSQ..AQAGTATPGSTPQPTVSPDPTAS................LTPAATPSSLDPSLD..PSQ.....DPDARLIDVTD..ETWG........................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.56|      15|      17|    1528|    1542|       2
---------------------------------------------------------------------------
 1528- 1542 (28.69/12.33)	SATNNPSHIPNSNNP
 1548- 1560 (25.81/10.22)	SRTSSP..FPASTNP
 1566- 1580 (28.07/11.88)	TPSSSPASAPPSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.13|      24|      38|     296|     319|       3
---------------------------------------------------------------------------
  198-  226 (38.73/17.07)	RPSTLNTPQ.DTHDLSSSDLHW.LTsisahW
  296-  319 (43.77/20.17)	RPRTTTVEQ.SIAKWKSTVIRW.LG.....W
  335-  360 (33.63/13.92)	RIRTTQATPfSTSSLNSSSHEWdIL.....W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.21|      36|     368|     253|     294|       5
---------------------------------------------------------------------------
  253-  294 (46.06/41.58)	ASQQEQliGRVIRVAPNGLLASIVTfdDPLDtiAVETTSRQK
  628-  663 (61.16/34.61)	ASQSNQ..SELSTSNKTGQGAPIAA..DPVN..ARTTTTREK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26677 with Med13 domain of Kingdom Fungi
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