<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26676

Description Uncharacterized protein
SequenceMADPAQFHEEEDADPPALSFFPDPPPFFKYFSSDNIARLKEIENQSVTGDEIAPNNPSATTSRLSAEQILALPTELRYLIPPAPPADDEEFHVFNEKTRAKGTDVFDKNMEHISDMLRMEGIFPEGWKYKPLPNDTAAAGAFATFTHQQKLYSCLRSLLLAYLKLLGIMASDPTSQMKTNTLEDMLTLVTNMHALINEYRPHQARETLIEKMEAQVERKKKEIEGVKQVAERVRGVLDDFSREAEELQKANENKLGEEEKTILWRPVNYNALTCTTTSRPWQQCVYHASQPHHDVTPHLRARGASEGHRLHVTTKYHNPLLYQYLDSWCIEPFCRTIWSARSGAIATRSPGRHQEKAKQLTGEYHSGPKTKKKAFQFGHWIICLLAVDNLAMSSATTPRPSKRLVVFCDGTWVGRETAVADAPPSNIRQLANMVGEVQYIDDSNRKPATVHPIKPQKATSTTTRHSNGTEWDTQPDVVAGYQEGVGLNRTFLEYIWDGATASAIGDECISVYRFIAERYTSDHEIWLFGFSRGAFTVRCVAGMINNCGIIKRLPEYTEDEFQTLCYEVFRTYRSNLPVDAPKSDECQRWKANPGRVWPAKRPIRFMGLIDTVGALGIPRLNAGIGFDWSPFEFFDHNVSSVVQHVYHAPALHDRLWIFQPCLVYPSEEDQKETAVVHQQWFPGTHYDVGRMTFRFVRQSPANWVEDLLGWLPDLLSRTIYPNEVLSDAVLRYLVEGIRDTDEDSSNPIVPNLDNEIETLRLRLTSPSPQQTGSGDIYGDVLNYAPAGIIWGTFQRFFRTIFALLNKLLPRLGDNIEELIGIKTIIGILTATADRRIPGSAENVYPYMDEEQIVVQGTKRALCVAQAAQMKGKNEWGKERGSTRRRSEQDSLRSFGTSLHVTVVYIITREMPILASSNSDVKIPHFAVMGRRAGLSRFVNPRTGLSVRSVTIPRGQYHRVFATHALHEMMLDGDQHGTSIYQKTMNGHGRPNMVIKDSTRSKWPRDQVEMYLILFGAVFLAPIVVCTSFDGNLNYHSPSRRHKSLAIDVSKVSKRTLTKRAAPWNPAQLNFTHAVASGDPHPDSVILWTRIAPSTESDQSNVTVSGYVPYYSHETEQYIKASANPICVEYHVGKDEKLRHVVDKGTVYTTSDIDFTVKVEAKNLHPFQTYFYQFKVCGSNNTSPLGRTKTSPDYDDDVSNIGLAVFSCSNYPSGYFNAYGNAARKDEVDFFVHLGDYIYESGKGKPGVNERATNPTKEIFSLYDYRTRIGQYRSDLDLRLAHQNFAWITTWDDHEIANNGYRDGFSNMNNTEASFKKAGGISVDTRKMNAVRAYFEWMPIRQVDLDDNLRIWRSFKMGKLFDLIMLDTRNYDRSITTLDWNDQYIEKLKDDTGRSLMGSRQENWFYNQLSESHDRGAIWRVVGNQIIFSHMNNSAVYSEELNADQWDGYTANRNRTLHHLYANSIPNTAFLAGDSHANWVSDLVWLDDKPYDPVTGAGAIGVEFAGTAVSSTGYGNGRSISNSSDRSAALVRDNPELQWTEGYYRGYYELFVKPEELRAEFYGSPSVATRNPYEISLANFTVKAGANHLDRSVAGGKVESGALQRGETVPTNLTLDTETGTWDVRGFEQMFIKY
Length1633
PositionMiddle
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.10
Grand average of hydropathy-0.494
Instability index40.49
Isoelectric point6.22
Molecular weight184887.51
Publications
PubMed=21326234

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
acid phosphatase activity	GO:0003993	IEA:InterPro
metal ion binding	GO:0046872	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26676
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.06|      34|      81|    1048|    1081|       1
---------------------------------------------------------------------------
 1048- 1081 (57.03/45.61)	VSKVSK.RTLTKRAAPWNPAQLNFTHAVASGDPHP
 1131- 1165 (46.59/35.43)	VGKDEKlRHVVDKGTVYTTSDIDFTVKVEAKNLHP
 1178- 1211 (53.44/42.10)	SNNTSP.LGRTKTSPDYDDDVSNIGLAVFSCSNYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.91|      72|      81|     519|     597|       2
---------------------------------------------------------------------------
  519-  581 (78.42/68.57)	................YTSDHeiwlFGFSRGAF.tvRCV..AGMINNCGIIKrLPEYTED.EFQTLCYEVFRTYRSNLP...VDAP
  582-  649 (91.68/57.64)	KSDECQRWKANPGRVW.................pakRPIrfMGLIDTVGALG.IPRLNAGiGFDWSPFEFFDHNVSSVVqhvYHAP
  665-  693 (33.82/15.09)	PSEEDQKETAVVHQQWFPGTH....YDVGRMTF.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.50|      26|      81|     407|     432|       4
---------------------------------------------------------------------------
  333-  359 (43.48/23.47)	FCRTIWSARSGAIATRSPGRHQEKAkQ
  407-  432 (48.02/26.65)	FCDGTWVGRETAVADAPPSNIRQLA.N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.97|      51|      86|    1254|    1307|       5
---------------------------------------------------------------------------
 1254- 1307 (83.02/71.37)	PTKEIfSLYD....YRT.RIGQYrSDLdLRLAHQNFAW.ITT..WDDHEIANNGYRDGFSNM
 1338- 1396 (74.95/49.96)	PIRQV.DLDDnlriWRSfKMGKL.FDL.IMLDTRNYDRsITTldWNDQYIEKLKDDTGRSLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      14|      57|     746|     759|      13
---------------------------------------------------------------------------
  746-  759 (25.06/16.81)	NPIVPNLDNEIETL
  805-  818 (24.26/16.01)	NKLLPRLGDNIEEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26676 with Med7 domain of Kingdom Fungi
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