<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26675

Description Uncharacterized protein
SequenceMNPRPGPSLHESLQSRGGAVPPSSQARRRPSRPLIQPDCIDPTLEDERPPVHNGAPDASRPPPKGRPQLFYTTNASNGLALPIHAFPLQPAANLPAPPRPGSVHLRNASQQRRIQPGGTGVKDYPKSNVHELVPSPVHVGLGKPADVFPWTGNNPEDTLSEALVKAGISNKPQIMNETNTARPSLWSNLKNKSGLTTLSTLFVAVLEKRQQSGRLQVPNTFKPPPRLTLRDSTREQWLHDLSNPGTSLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTITWGRGWTSSVEQFMDSVIGAIGQGDWKPRVTYALQLATHLYKEHLLDDDHFLDWIIHGLDTCPSERLFIWLLIIQISHYWTDITSCRRRGRRLAESLLNHLDKIYRLEDSGPQSVVLQYLENTLTKLLIARPACLLLPTTWAKHSAQLRRLTERRTHPQMKQAIKRIEQRNSRLLQSAKTRSSTMQSPAGRIYRLLDTASDVHPYRVEDLSFECMEIIPDATLLIATVLQWACSCYREGVHRTYLITRLLRRWSHQGADVYDGVISYLRDMSWVGTGDLSIIFRIIAELVRSKTFATGRYLQWLIATGSLGHDSDLSSPDAWPVRLITEIPLTGLPDQIRTLRSTLLRGTAHAAEVERETLLRAEQQISHTLPAMFGLYNIKVKSPDIKLDSLSPTIKLELGIWLRGNVASYAEVNERVPTKDPSVEETAAVSLISPLEFHIVRSYLERFGDPAILADVVGIAATSLDPSVLAAAADTINYHVKAFRAMGACDPLFGRIAARYAALRTMRFPERELLLSLSNLARVLHADGQLLQLLGYDLSRLDQKNSLAACSPASDNMGEVMQTSSYSDDEIERVLSSGTSMDQQMMARVLRKIINNHQEQVHKGQAHFESYPAWFHRLRSFDEPTFEMVTGEWLSSTLTAHQIDVLRVALPTLVGSGCVALQTFLDTLQASVARLKNSPTEIGVQAAVEGLRILLPCDTLAASCPPQDAYRYRLEQRKLGGRTQRCVGDIVGLLSANSSQTVQGQVSLLLMSEPMLALMKQSVVADPGNLSNLSRETKGLFVTPLLDVLLDPSGSFQIANVSPAEKVPIVFEIASDLSLPICQAVIEHIFSSQSALSGETIDALPAALLSAIKTAVEEDRSAGLELLASLEASLTDQVRQHAEREILNASAFLAQGSSVKSDEIYQHSPAVVQKYLTVIDLTCSKGVEDTDQSAMVIALAERLKGIAQVFGHCEALVAQTGQKNDAVVLSLYAWLNALLRLAIAHCPAMLRNATHQHQSVLMSAMKSLITHPFLALYPSVTEHIFDVAIFLSDYISDDVRHQVARLDNIRPTDDARCLFMLGATAPVDGWLVLTKPLDPLTQPSSQSSTPGPIQSQPQPYQSSQTSAAGPAIPQQRYLNQQRHPQQQHFQNQQAQQGQQAQQAQQAQQQRQYQQYPQHPNKMLPAQLQRNPSFQNSQSQLQQMQQMQQMQGLAQQRATQPSPVYTQRPTPTSQNSHSGAAPGKIQIRHEKEMRQYPFVQPRWEILADSSGNPNANETAISLSLFGARKV
Length1574
PositionKinase
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.06
Grand average of hydropathy-0.288
Instability index53.48
Isoelectric point8.77
Molecular weight174494.09
Publications
PubMed=21326234

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26675
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.69|      40|      87|     405|     444|       1
---------------------------------------------------------------------------
  405-  442 (59.33/35.71)	....................K..IYRLEDSGPQSVVLQYLENTLTKLLIARPA...CLLLPTT
  443-  501 (36.76/19.14)	WAkhsaqlrrlterrthpqmKqaIKRIEQR..NSRLLQSAKTRSSTM..QSPAgriYRLLDTA
  507-  530 (34.31/17.34)	........................YRVEDLSFEC............MEIIPDA...TLLIATV
  533-  554 (34.28/17.32)	WA.................cS..CYR......EGVHRTY........LITR......LL..RR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     206.60|      38|      38|    1427|    1464|       2
---------------------------------------------------------------------------
 1380- 1415 (51.03/22.34)	.KP.........LDPLTQP.SSQSST..PGPIQSQPQPYQSSQTSAAGP
 1416- 1461 (64.06/30.01)	AIP.qqrylnqqRHPQQQHFQNQQAQ..QGQQAQQAQQAQQQRQYQQYP
 1462- 1507 (50.23/21.87)	QHPnkmlpaqlqRNPS...FQNSQSQlqQMQQMQQMQGLAQQRATQPSP
 1510- 1541 (41.29/16.62)	...............TQRPTPTSQNS..HSGAAPGKIQIRHEKEMRQYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.84|      24|      25|    1138|    1162|       3
---------------------------------------------------------------------------
 1138- 1162 (32.29/21.11)	QSAlSGETIDALPAALLSAIKTAVE
 1165- 1188 (37.55/20.62)	RSA.GLELLASLEASLTDQVRQHAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.38|      16|      25|    1068|    1083|       4
---------------------------------------------------------------------------
 1068- 1083 (27.47/16.23)	VVADP.G..NLSNLSRETK
 1093- 1111 (16.91/ 6.98)	VLLDPsGsfQIANVSPAEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.80|      44|      86|      24|      68|       5
---------------------------------------------------------------------------
    3-   62 (68.92/31.70)	PRPGPSlheslqsrggavppsSQARR.RPSRPLIQpDCID...PTLEDE..RP.PVHN..GAPDASRP.P
   63-   97 (28.28/ 7.93)	PKGRPQ..................................lfyTTNASNglAL.PIHAfpLQPAANLPaP
   98-  150 (57.60/22.56)	P..RP........gsvhlrnaSQQRRiQPGGTGVK.DYPK...SNVHEL..VPsPVHVglGKPADVFP.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     273.99|      67|     116|     752|     818|       6
---------------------------------------------------------------------------
  709-  748 (21.52/ 8.97)	.GNVASYAEVNERVPTK.DP.SVEE.TAAvsliSPLEFHiVRSY..............................
  752-  818 (110.55/84.36)	FGDPAILADVVGIAATSLDP.SVLA.AAA....DTINYH.VKAFRAMGACDPLFGRIAARYAALRTMRFPEREL
  829-  871 (51.68/34.51)	LHADGQLLQLLGYDLSRLDQkNSLA.......................ACSPASDNMG...EVMQTSSY.....
  872-  933 (90.25/67.18)	.SDDEI..ERVLSSGTSMDQ.QMMArVLR....KIINNH.QEQVHKGQA...HFESYPAWFHRLRSFDEPTFEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      22|      25|     939|     960|       7
---------------------------------------------------------------------------
  939-  960 (36.67/24.00)	LSSTLTAHQIDVLRV.ALPTLVG
  966-  988 (31.31/19.27)	LQTFLDTLQASVARLkNSPTEIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.02|      14|     117|    1197|    1211|       8
---------------------------------------------------------------------------
 1197- 1211 (21.03/20.28)	FLAQGSSVkSDEIYQ
 1318- 1331 (24.99/18.43)	FLALYPSV.TEHIFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.59|      13|      24|     297|     309|      14
---------------------------------------------------------------------------
  297-  309 (26.53/17.49)	GQAGTITWGRGWT
  321-  333 (25.06/16.03)	GAIGQGDWKPRVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.04|      12|      24|     670|     681|      15
---------------------------------------------------------------------------
  670-  681 (21.94/11.17)	ISHTLPAMFGLY
  695-  706 (21.09/10.47)	LSPTIKLELGIW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26675 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALPIHAFPLQPAANLPAPPRPGSVHLRNASQQRRIQPGGTGVKDYPKSNVHELVPSPVH
2) DPLTQPSSQSSTPGPIQSQPQPYQSSQTSAAGPAIPQQRYLNQQRHPQQQHFQNQQAQQGQQAQQAQQAQQQRQYQQYPQHPNKMLPAQLQRNPSFQNSQSQLQQMQQMQQMQGLAQQRATQPSPVYTQRPTPTSQNSHSGAAPGKIQIRHEKEMR
3) LSEALVKAGISNKPQIMNETNTARPSLWSNL
4) MNPRPGPSLHESLQSRGGAVPPSSQARRRPSRPLIQPDCIDPTLEDERPPVHNGAPDASRPPPKGRPQLFYTTNAS
80
1383
159
1
138
1538
189
76










Molecular Recognition Features






MoRF SequenceStartStop




1) GKIQI
1527
1531