<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26671

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPNYEHPQLAFGPWDMASSYIWAFVPVSFKYLYSIHWTVFSTGNPPPFPVVAKTWRTTDPSSTSSSSTSSSSSSSSSSSSSSSSIIHSLPGWLAWHVVQQWMGVEEQSSSQVRARAFTDQHEALANWTRGAANDEGCTRKERSRLSRGGRQQAKRASSKLQGSFQLPTRPDQTRPDLARYSMDVDDLFGDSENVNLQTINVAPPVKGLARRIDDLRSSGCCQRIAWSKNGCVAYITPDGYSVKLKVFFRDPATAKWDLGKDVPLEFPQGHDVYPLVHVSWSNLGNDLAVVDEAGRAMVFSCAMALDRLQFVPVELAHPESEADAVVGMHWLAILPYEQKSHIAWSAVRDGAKWKWNIRSHKFHDAHHPIDSKASFIYLKRHGELRLRFQQNDSAWQESSAQLGPMVSTKEPFTHAAFASNNGKNQTKSLLLAAYDVNRRLHLYRIETTWNIPADKQPNRVTPFEKPTIQVVLIAMEDNTSPIDLTAADLSNGTEPQGTAAAQLTHLNFLPITPEHGDGSLPTIQAIFARPPNMIACDQMSPQETLHSVIVKWTVLQSQQNQVHPSLDQVTSKKKGVNSVSGRTIFLLQRQPDFTLHAVVLAFYPIWYNMLLAFCYSDGTLEFRKRSTMEIIMPDGNTNTVTSLLQAGYVFSHAEPSLHVAFSPNHCIAVCMQQEGGIKLRPMEYQNGTITDEEDPRHSAALAALVLQSSSAAHQYYSSDDIFAILGPLSEKRKQDFIALLFDGLDVNIDCGIDDMCNNHLILLGRAPFFVKTLSAMHILGLEGIVSRSLTSKIAWIVLNIKYVTQILTTIARIHNQKSPLESNSLRPDGVPQLIGVCRWMMHFMAYILDELFSLGREIEDIPPESLTREVLEQKIHELNKPAVLILLSAFPRFMMKSWAHPLAWVKRSADTLTHSSTPVPAPEIRRIYTPLHVALNELPFEWRWFEMLVVETHNLVRGTFKKAGLSDSQRNAVERDLLVGKIPDVLFPVAKRLVTDRLWNSAQPGGCLADKLDVGRLMFFDTTWLGFTESKRARLWHQSHVVDVCQKMVIRGRGKTVYPGIAGPLQGQGQGHSQGQGQSQNGDRNDGLRSVHGAGLGAVGGLEEPGKKARLRQCVRCGECMEDVVQGLPGYSLTHASWLMGVAKHCNCGNSWMLADDKKGAK
Length1162
PositionTail
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Leptosphaeriaceae> Leptosphaeria> Leptosphaeria maculans species complex.
Aromaticity0.08
Grand average of hydropathy-0.271
Instability index50.44
Isoelectric point8.00
Molecular weight129442.95
Publications
PubMed=21326234

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26671
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.65|      32|     123|     511|     550|       2
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  511-  550 (45.46/49.29)	ITPEHGD...GSLptIQA..IF..ARPPNMIAcdqMSPQetlHSVIV
  631-  669 (45.19/25.88)	IMPDGNTntvTSL..LQAgyVFshAEPSLHVA...FSPN...HCIAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      24|     123|     892|     925|       4
---------------------------------------------------------------------------
   89-  114 (41.73/15.52)	LPGW...LAWhvVQQWMGVEEQSSSQVRA
  895-  921 (39.55/27.46)	MKSWahpLAW..VKRSADTLTHSSTPVPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.32|      17|     120|     261|     284|       6
---------------------------------------------------------------------------
  268-  284 (35.36/36.73)	QGHDVYPLVHVSW.......SNLG
 1126- 1149 (30.95/13.37)	QGLPGYSLTHASWlmgvakhCNCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.39|      37|     691|     330|     411|       8
---------------------------------------------------------------------------
  330-  370 (62.96/87.11)	WLAILPYEQKSHIAWSAVRDgakwKWNIRSHKFHDAHHPID
  428-  464 (63.43/19.32)	SLLLAAYDVNRRLHLYRIET....TWNIPADKQPNRVTPFE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26671 with Med16 domain of Kingdom Fungi
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