<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26669
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSDSFSLPLRPVRKKTDEPDTLPIRIAQINAQRGSFKDVTEESLSQEIASLRESGKQEPDIQETEDSGNDAEDREQRLFTSRSEMLEFATQAQVEACYALDFVSLALSKYAPRQVEVSMTPYVKQKIPSGSLGIDLVKTPEKTEANKKDIEIVSKGWKLESFSSAANNLLEAATRLQKEVAAETKYWSEVLAIKEKGWKICRLPRERQSLGVQHGFLEAAPVFRDRGLSALRRAGDGSLYVDQGIHATPPKAVRIRIQDNENIVGVSQPACIKHDDNTSTEETFIHQARDSLFEEELFYELNREARSLLRHGVETRQNQILFHLSDNRRVLVDFVPVGEDATSDQDKAEGLPANDLAHAIACSIRLLLNHAHRKNHRHRTSIPTAISIKKRPTAEYPLLQPSIAYLQHGSHLQWLNSCLHNITATLFSAGLKYRYWKNKPLPRDTQETATNQGKAIPLVESLVDTFLSVQEARMTGYFYSQDNFYNIVVRTDLSPAALGTEFTVSTVHSSLPHGRITQRFGTREDLKEYFLYLFTLDIVQNIPFRGNTSSVSAVPNTSHGETGTNSLGADENNTKSAIWEPIFAENGELTSYIPGQSQNKKLKVTLNEESLELLCMSLSSTANTVEENKYLWSMDQTKDEPQITLQEALRRLEAKE |
Length | 656 |
Position | Head |
Organism | Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.540 |
Instability index | 47.50 |
Isoelectric point | 5.82 |
Molecular weight | 73849.02 |
Publications | PubMed=22951933
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26669
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.14| 25| 37| 584| 608| 1
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584- 608 (41.59/31.03) AENGELTSYIPGQSQNK.KLKVTLNE
622- 647 (39.56/29.13) ANTVEENKYLWSMDQTKdEPQITLQE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 110.54| 35| 42| 363| 398| 5
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363- 398 (57.14/44.57) SIRLLLNHAHRK..N...HRHRTSIPTAiSIKKRPTAEYPL
402- 441 (53.40/36.52) SIAYLQHGSHLQwlNsclHNITATLFSA.GLKYRYWKNKPL
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