<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26667

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPIGAETNVRVFDELSTCYWRVYGVDFNERGLGTLGSSINQLFKKVQICALALREAGCLTCPSSDGVGIWIFSLDAEFSRLKSFTSSQSKYSQDIIVGQVPIHEYCGGTTSLAELSQKLLSKASDNLLNSSQTEELSDRNRLEIPASLELTHSSLYASFISSIAWSFSLYLAKRHGAIPLGKRTFFTVADPDTSPGGASGCIISTLDIETSQSGKVAVSLRPRFQPGICQLSESPGPSSIGELRLHDDIWLAPTGTIARYIGIGGSEYALGTGNSYNTSNSAHCSKNGFSGEGQDPWKMAVCSWLERTGVPIGVSDNMRWIQVEVVARHQRLGQTKANGTRRIYWPAQLCFRKARFPKGSPIQGAKTLSRDSLGPLQYAHQWLKCSLPKDEVLSRNPPPDVTQPAEQHPQSELVGIPRFPPSYGIPNPPGGALGFGQLPSDHPGGQYPLEISQASREEPDANIAESLNPNTRSLIEAATPGLGTGAGMYDTAADDDLFEEIGDNFDDKGITEADFNFFDEPGLSDTNLDVDSGNLSHNFVMSDHPTVESKTDLEMNESSASLEPVGPAEPGGMETPMLDNAVEYNTNQGQGELNSNQPVTGVADAERSAERPISPPLSPSGVKRILFSNATGGSEKAKNTLTSAVALPIGANNQLGQHKGRYDAIPFQHELGFSDRKYGIDGRFWFLPDRKNTNQNADSNVTTIPMVNDPPGPIYKLGQQDYNHKGNERINCPDNERCSASDSSTSSVSGDDYEQARTDKLRPLDPIDTRLRRGDLEEIFSVSSSLQSPGFNVRKPYTTPSDLEEDVLLAGLIYPATDWLLSGYFKAFEPSVRSVLCGRDEMLHVAQLLVDQITQSTLAHKMEITYEENEKDIWQSSIDDISALGQSRRPNLKCYASISDIGPSQQMKDATGGGIINLKPPHMHIRRGNCSLEVLPTAISFWETFGLEPLKGKKDIISYCLHPVSMQESASAFLDRLGLTYLGANLGTFSRPGSAKGLVPWSLGQDKLDYTSIMRKLQHICESLVGTAMSNLSMNNKTAVVYIVNPFKIGAAMVDICAAFLRLFHKYVEEADKRAVRRLNELVLQIIPSDFIAGDDSLVIPTQNEYLRLALEVYSRCPPQQPISDMFGAAPAFSLAPSVPKMIPFRLTAEEGSPMDAGKACHVAYSVSQDQRWVTAAWCDNLGLRQLTLSYSLRQDVSHTCRPLSEVREDIWQVTVDMTGMSCCRWRVVIAKDEPMDTEEITAWTNLAARHNQHHPSQVDLALLTVNIEPNLRMKLPPPPPQLNALYQSGNASTPVSTPKPSISSPDPSTSASTPPNISSTPNLSSEPALSQTQTNVQVHPTQVPVESNTETLLVDKSDDSWALILSQRLNNSHSFTNYNPALANGYLIHRSGTSDNDWKASLMVNLIHVQTRIPPSIILKDLLSIYRDMASLTRARGLICSRENHGLPWHISTAIRGQELLGCIL
Length1468
PositionKinase
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.07
Grand average of hydropathy-0.355
Instability index44.45
Isoelectric point5.35
Molecular weight160676.86
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26667
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     341.58|     117|     335|     100|     229|       1
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  100-  229 (181.50/140.94)	GQVPiHEYCGGTTSLaELSQkllskASDNLLNSSQTEELSDRNRLEIPASLE.L.THSSLYAS.....FISSIAWSFSlylakRHGaIPLGKRTFFT...VADP..DTSPGGAS.GCIIS...TLDIETS.QSGKVAVSLRP..RFQPG
  438-  573 (160.08/96.58)	GQLP.SDHPGGQYPL.EISQ.....ASREEPDANIAESLNPNTRSLIEAATPgLgTGAGMYDTaadddLFEEIGDNFD.....DKG.ITEADFNFFDepgLSDTnlDVDSGNLShNFVMSdhpTVESKTDlEMNESSASLEPvgPAEPG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.61|      44|     336|     834|     941|       2
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  834-  881 (65.58/127.59)	VRSVLCgrdEMLHVAQLLVDQITQSTLAHKMEITYEENEkDIWQSSID
 1176- 1219 (78.03/27.68)	VTAAWC...DNLGLRQLTLSYSLRQDVSHTCRPLSEVRE.DIWQVTVD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.97|      41|     335|     264|     338|       3
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  275-  324 (65.80/90.62)	GNSYNTSNSAHCSKNGfSGEGQDPWKMAvCSWLERTGVpigvsdnMRWIQ
  980- 1020 (74.17/30.36)	GLTYLGANLGTFSRPG.SAKGLVPWSLG.QDKLDYTSI.......MRKLQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.69|      33|     158|    1109|    1146|       8
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  385-  427 (48.07/20.96)	LKCSLpkdEVLSRNPPpdvtqpaeQHPQSELV..G.I..PRFPPSYGI
 1109- 1141 (60.78/29.80)	LRLAL...EVYSRCPP........QQPISDMF..GAA..PAFSLAPSV
 1274- 1305 (41.84/16.62)	LRMKL...P.....PP........PPQLNALYqsGNAstPVSTPKPSI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26667 with Med13 domain of Kingdom Fungi
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