<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26663

Description Uncharacterized protein
SequenceMITSHPPQMSNPYSQPSTGFSDLPAARMAFQQQARLGPGNDLGRGLGPGRTGRLGGPGTNASPVIDLTGSNDEDDEDLESSRPAKRLRIDTQGHDEIARILHSGARLVHVLSDDTDDGQYEAVDENEPFVESVKPPASFQDRLAYMSMDGGGQQSQSSPAPLPMPPRPRRSIFMRDRPENAVEDAEPDDMVVKTTPYTMEKPAAAARLADNTILDFHPWTGNNPEDSLNEHTAKQGFYDRIQLSQNESNTARPSLYSHFKNPNGLKNLSHIFAQALKRRQAMTKVTPNSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKNIPIGRAIWLAKCVGANEIRAFKRKGTAAAIASGLETKWVKDWTGSVQQFIEGVLQSHEEAGWIENQAYAMRLSGRLFLEQLLDQDAYLEWFLSSLHASNLKTLPTWLTTISVYWKNLTIYRKRSRRLAQTLLDKLALALDINRSTDLSSLINQLQSIIRSFITSYPSSFLLPLTWSRHQKPLTACFNTSVPLETAILAQLIVRNTRLSKTSPQSVTNSPELTSRPAAQQLISLLDGPCAPNAFPLLAAKCLALPLDHPTLVHTLLEWSSTPFRYGCARIYVGVRLLRRWRKLSIDTDAHILYFLAANSKHSARQLDNVYHLVAELVRSQSFSVGKYLEWLVARGAVRSPDKPGQYLTADVELLRHLPPSRLPEHIWNLRNTLLSRAGVSVDDEARQVRHIKTGLLQMHSDIFTGHVDASDTEMADADVDCTCLTWTVKSEVSHWIREQVALKLLAQVQVKNQPSGGGTTQTTAAMLRPDQFYSLRSILERLGDISILADVLKLLSPSADPTILASLTDTLNYHLPAFTAIGATMDLFQSLAISYTKLSKTEPHVQYFIGSMLDMALAIPSEATTVAVLRRDLIRYDKKSAMAASSPVSEHMADTLNPVNPTFGGMLDQLLASGNCMDDATLLRIFELLIQKLETGKADISITSSEAARYLAQLRLFNPKTFDGLMIKRVVGMIRTSPRPRLSEFLPPLVGVGCVTLLAFFGMVKGLLEADKMGENNIPDVMQLRLDMLGVLGLENAGPSKLPDFVLYRFKIARRDFVLKHCGLIIGTIRDAIIDATDSHDVSLQEQWDTAIFPLLCEIMVRHPNIGKAESAKWMTDKFPTGLRLLTQTLDSLLNLESGNGNFDILQLLKGDYGRDANLRADPNHTSSNSQPIQKQALDIVCRIDDFSLPFCLTKLQLLLEGTDMAGKENILDPVFAAAEADVKKGVIPMGGTKKGPGLIIRKIKQKAEIKLLSLFITSASSSSTGNSADSDDGPAPHELALIYLRIIEELICKSPNESISPSIGSALLERMNLLLQRVAFLSKIKPTETNSIIIAQRNEGGMLGVWVYILLRLVALYRSSFNVERASKLDLTDQTRLLLSICYMAFTPALVQVLSRTTNLPTVPTSKYSHLQKTVPANWSSLRTYAIDVATILVDTLPDEARIQCARFLRDRSPLFHQQQQDTRLLYLFGPMPDPQAAPTNPSTGNPMPGPPVPGSSPLSVQSHAAQGSSVQTPHQANQPIPTVEETTSPVQNFRFQQGNRILGPCPPRSWEMIEESAPVVGVNDTAINLSYFGARAIRAGLK
Length1635
PositionKinase
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.06
Grand average of hydropathy-0.205
Instability index45.15
Isoelectric point8.48
Molecular weight180709.08
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26663
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     494.82|     123|     209|     778|     905|       1
---------------------------------------------------------------------------
  400-  528 (143.33/76.19)	....EEAGWIENQAyAMRLsgrlfleqlldqdaylewfLSSLHASN....LKTLPTWLTTISVYWKN..LTIYRKRS..RRLAQ..TL.LDKLALALDINRSTDLSSLINQLQSIIRSF..ITSYPSSFL.LPLTWSRHQ.K..PLTACF.
  531-  646 (153.93/80.12)	SVPLETA...........I...................LAQLIVRNtrlsKTSPQSVTNSPELTSRPaaQQLISLLDGPCAPNAFPLLaAKCLAL..PLDHPTLVHTL...LEWSSTPFRYGCARIYVGVRLLRRWRKLSiDTDAHILYFL
  778-  900 (197.57/115.87)	TVKSEVSHWIREQV.ALKL...................LAQVQVKN....QPSGGGTTQTTAAMLRP..DQFYSLRSILERLGDISIL.ADVLKLLSPSADPTILASLTDTLNYHLPAFTAIGATMDLFQSLAISYTKLS.KTEPHVQYFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     105.75|      24|     313|     702|     729|       3
---------------------------------------------------------------------------
  702-  722 (32.43/13.10)	.........VELL..RHLPPSRLPEHIWNLRN
 1022- 1042 (28.12/10.28)	.........VGMI..RTSPRPRLSEFLPPLVG
 1047- 1077 (24.54/14.95)	TLLaffgmvKGLLeaDKMGENNIPD.VMQLRL
 1078- 1097 (20.66/ 6.43)	DML.....gVLGL..ENAGPSKLPDFV.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     346.98|      83|    1324|     162|     253|       6
---------------------------------------------------------------------------
  162-  245 (141.14/92.22)	LPMPPRPRRSIFMRDRPENAVEDAEPDDMVVKTTPYTMEKP..AAAARLADNTiLDFHPWTGN..NPEDSLNE..HTAKQGFYDRIQLSQ
  265-  337 (94.10/69.92)	............LKNLSHIFAQALKRRQAMTKVTPNSTFKP..PPRVTLTDN...KREAWLRDlaNPSVPLRRlsRTIPHGIRGKILLDQ
 1489- 1560 (111.74/66.46)	LPDEARIQCARFLRDRSPLFHQQQQDTRLLYLFGP..MPDPqaAPTNPSTGNP.MPGPPVPGS..SPL.SVQS..HAA.QG.........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26663 with Med12 domain of Kingdom Fungi
Unable to open file!