<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26662

Description Cyclin
SequenceMAANYWTSTQRRFWLFDREQLAETRAALDEADQAFIAQYPLPDHRLVNIYINQQLIKLGKRMSTRQQALATAQVYVKRFFTRVSIRRTNPYLLLTTAFYLACKTEECPQHIKYVVSEARGLWPGGEFILSDSAKVGECEFWLISELNSQLIVHHPYRTLSDFSTTLTNPNSTGLTLTSDEIALAWSVVNDSFLTDLPLLQPPHVIAVMAVFVAVVFKPGTSTGMVVGPGTITSSSSTSSGATSSSSTTGTTGTTTTMTTGPGTGSATSAGMAAGIREGMGDGGRVQKAIEWLAGSEVSIEAVMDCTQEMVALYEVWEGYGEKGLREAIGRYVRGRFLDK
Length339
PositionKinase
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.09
Grand average of hydropathy-0.079
Instability index35.94
Isoelectric point6.01
Molecular weight37070.64
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. 
ECO:0000256	ARBA:ARBA00002306
ECO:0000256	ARBA:ARBA00003882
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26662
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      18|      88|     164|     182|       1
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  164-  182 (27.24/17.38)	TTLTNPNSTGlTLTSDEIA
  255-  272 (33.22/17.41)	TTMTTGPGTG.SATSAGMA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26662 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VGPGTITSSSSTSSGATSSSSTTGTTGTTTTMTTGPGTGSATSAGMAAGIRE
226
277










Molecular Recognition Features






MoRF SequenceStartStop




NANANA