Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAEILAPLTSLEARLNALLTSITSTPTASGAPAATVSLLEADDALSNALQTLRTHQANYSKILRLRAEALSLEERVRETVRQVGELGDEISAAAGEDDDSDEDSDDGAGSDVEMGEKDKDKIRKGEVDYRLLLGFARRISKYNNEAAADASSTTMLSKEPPNADTAAEANGEIAKKDGMAVGHGQTTGVGIAALPQDTVSWLDETANWTRLMSALPYPSEDRIRMGLMAHLHATAAAEGKDIGKEVEHILQAAMQKDMTNEETQSAGQGYQPQPDAGVGHPAETGTASLNHQAGNSASHTAEPAKVKPKLDLDLYDPDDDDM |
Length | 323 |
Position | Middle |
Organism | Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.560 |
Instability index | 27.73 |
Isoelectric point | 4.51 |
Molecular weight | 34291.33 |
Publications | PubMed=22951933 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26660 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 204.22| 63| 96| 157| 222| 1 --------------------------------------------------------------------------- 157- 222 (100.95/72.48) LSKEPPNADTAAEANGEIAKKDGmAVGHGQTTGVgiAALPQDTVSWLDETANWTRLMSALP...Y.PSED 255- 321 (103.27/63.56) MQKDMTNEETQSAGQGYQPQPDA.GVGHPAETGT..ASLNHQAGNSASHTAEPAKVKPKLDldlYdPDDD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ARRISKYN 2) KGEVDYRLLLG 3) NSASHTAEPAKVKPKLDLDLYDPDDDDM | 137 125 296 | 144 135 323 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab