<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26657

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEETLDDLFGDSGGLDLSLSAPAPPKALPARIDELRMLGCCQKIAWSKAGAIAYISQDGSKAFLRNLRCSPEEGKWSLSEGDHDHPIAEAQSGHTLVHLAWNEPGAELAVVDSCGRISIIGMSVGLNVLMQSRPAVLDPDDDGNQPVGLMWLALNRSVHTFSHAGRTSGRWAYVRYPRRPMGPFHPLHKLALFVVTRSGKLKLLYQNQELKWGDMVIELQNTGYTDDVLMHASMTPVDGGGIMIVTYSASNELRLYRAMLKWEGSPVDSNTQRPNNSIAVPSVQLAHIEVEVPNVVPSPSTYVIGNEDNITNNANGLFALTHLQVVACPVDAPGGQTAPMVLAVFSCPIHNVHARPHLQHPSVIVRWEFRPVNQTLHRSFDSIASKQPRNPLLPSTELNRQADTYFERHIVSIDYMETGNLFAITTEDGNITFYDAKTFTPLSGVEDIETVTSLPQSGFTFPAAISPGIHISFSPSGCIAASLDEKSQVQLRVMEHSFGHEQDGLFNDGKFMSALAALTMAYCRACSSDSNNDDILMIVTQQLNQESHKKFINEVYRALSMNVTIEQDKLMNNPYILKCFSMQAALGFKNRLERRNLAAAVPWLTLQLRQISILLTYLLHFNKAGTEVDCHDPETLRIALGNVKWALDLAKYIVDDLFEISDNLNGQSSSQDSGSSSGKIYESLSTILIISSIPRSFLKYICRGLRGLANGFRTATNLSNESYQIYSQIVTVITESALKVDVYEKLLASVENDVKHAYQNAGFNNADRAAPERDLLINGSIPPVLQPAVTTILTKTVPMIRNEANPMYLFLQDYSWLGVGDDKRADLFRHKYEIDILRKVLIPLDESSGTARSSRRCVRCCAVSQDIPPKSVAAVKMLMRTSVLRACTCGGMWSMSNASSVKGSTALPGWR
Length911
PositionTail
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Nannizzia.
Aromaticity0.07
Grand average of hydropathy-0.142
Instability index51.73
Isoelectric point6.16
Molecular weight100486.49
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26657
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.03|      35|      47|     651|     688|       1
---------------------------------------------------------------------------
  651-  688 (52.74/41.57)	KYIVDDLFEISdnlNGQSSSQDSGSSSGKIYESLSTIL
  699-  733 (60.29/39.16)	KYICRGLRGLA...NGFRTATNLSNESYQIYSQIVTVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.83|      35|      48|     186|     222|       2
---------------------------------------------------------------------------
  186-  222 (52.99/48.24)	PLHKLALFVVTRSGKLKL.LYQNQeLKWGDMVIElQNT
  236-  271 (58.84/42.99)	PVDGGGIMIVTYSASNELrLYRAM.LKWEGSPVD.SNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.73|      25|      39|     275|     299|       3
---------------------------------------------------------------------------
  275-  299 (41.83/25.88)	NNSIAVPSVQLAHIEVEVPNVVPSP
  315-  339 (43.89/27.50)	NGLFALTHLQVVACPVDAPGGQTAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.72|      27|      39|     510|     536|       4
---------------------------------------------------------------------------
  510-  536 (47.71/37.29)	KFMSAL.AALTMAYCRACSSDSNNDDIL
  550-  577 (41.01/30.89)	KFINEVyRALSMNVTIEQDKLMNNPYIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.65|      67|     818|       7|      80|       5
---------------------------------------------------------------------------
    7-   80 (105.21/81.95)	DLFGDSGGLDL..SLSAPAPPKALPARIDElRMLGCC...QKIAWSKAGAIAYISQdgsKAFLRNLRCSpeeGKWSLSE
  826-  897 (112.44/68.02)	DLFRHKYEIDIlrKVLIPLDESSGTARSSR.RCVRCCavsQDIPPKSVAAVKMLMR...TSVLRACTCG...GMWSMSN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26657 with Med16 domain of Kingdom Fungi
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