<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26649

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCNTNAQAIGDFEAIAYQAFSIARTSTPTLSRTRDWGSADDIRATEAELRQQLQLAGQNNVHLPEIDGYRLQREHAGCIKAIDLVRPPVRAGTPNTSTTSKPSSSSGATSSLSGQGGSARPTQANSQPQASADPPQPPDCFTIYELFTSSVIALISFHIVQDCNVVALNYRTFVSRASTRLDNDQAEIDSPDVHRLTSMTVHWTSSGTLLVSTFTDPRTVIRCLGHVSTPAEESQLAGRCIRVAPNGMLATISSFEDPIESVVDEIGVRHRKRTRLTSLEQNIEKWKSSVERWLGWKGYALPDLDRRTSWVRIRTTPASLPASSPAAPGPDRDILWPRALCFFHVSQDHEITGAESSTPAGDHNMLRWFETPESVGFKDPLDAAQEWFLAKPDRDKLLEAQRKAKKAEEDAARRKEEQHNLYPSSPLNARAGTYGDLPAVSGVYPTPPDGVAPGAGISQSDTPSVSGTVSNVILAPGGSTPAINLSAPSDTKMEDQQLPLTSPVIPPAPDNHNTSSGNDDLFEDMDEDGFGGDRINDTDFDFFDGPDNDDVDMLDAPGLPDHNTAHMEASHESQHISEPQAQDDMSDPFAALENALATASEPVVSEETDVKGKEPATTQASSFDAPETSEKKAVVPSTLVKVTFSKEPTPPLSPSAVFKALQPSPPNKSGSRTQQWRPSSSQRNTQFDPVAFSRKMSMSDAKYQGGRFSMHGHTEPAIKKTTPSPGPGTTPVQAKSLRDFPLLTKLRLAVGMASANKIPEMTCLARAASEGLESSSDTSDASDEDSEQEEEIERTSVAILNSLVMPAKRKLQSEGNATPLSVTSFAESMGGDWHDLYALQLDEANLSTFEPSLFDWSLVNFPSPAERVATGARYSFPALLPSPSQMPDTPTSQPDLNYEVPEEKPPNGKDIISITQIVTDQIVSATLDVLGEDPPAEKTFAGNAAIEMHWQTAIKDVFPTAEDCDLPTLVGIHEVFQDYAALAKAQQRPPARKTDGPAVTSSHMYQINPPHLRVRRADTYWDLLPPAVAFWEPLGLSPISSPKNIVTFCVYPHSDALRPCLENFLLSLQLAYDSCKLGSHSRVETVVEFEGGLVPVRATTASTPRETFKLLKDTCIQLGRLLALQHTKIREQQDNNIDAFVIYMVDPFGGPSALWELCSAFWSLFQAYGQGPPGRPEQPQKPDLVLQVIPIKYIASFDAPVILDPSTYFNLAREVYDRCPPSAPSGDKTSLSIYSAPAFHLEETLPRNIPFKLVAEPAQDLLRENTYMHLGYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFREIAKEIWQNTIEILQSRRVNWRVCIAKAGVLEREELESWVFLISCPTQINVFVTLLTAVDADPPYQFTPTMSPSNQSTTAATANTPVSTPQAGVSPSDPGPGLTPAATPSADPSAADPAADPEARLVDITDETWGIVLAHRLHNSYSTTQFSPALISGLLVKRGETLQTRNNILHPIPDPEEGPIVVAVNFLWIGAVGSTRTTNSPFSSTSSTGTTTSSSSSSSSSSTADIPSPNTTGLPNPYPSTSTPQSPSPNPGQQEAGQRSTTSLMWTPTPQTRTTAEGLLKEVMGQFRALGLLAKLRGMRGTRGGTVPWHVVAAKRGVEGLGRVGGGF
Length1644
PositionKinase
OrganismPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index55.28
Isoelectric point5.04
Molecular weight178065.86
Publications
PubMed=21067574

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     906.40|     318|     342|     366|     704|       1
---------------------------------------------------------------------------
   55-  320 (250.40/95.06)	..............................................................................RQ.QLqLAGQNNVHLPEIDGYRLQREH..........A.....GCIKAIDLV..................................................................................RPPVRAG.TPNT..STTSKPSSSSGATSSLSGQGGSArPTQANSQPqasadppqppdcftiyelftssvialisfhivqdcnvvalnyrtfvsrASTRLDNDQAEIDSPDVHrlTSMTVHWTSSG.........................................TLLVSTFTDPRT....VIRCLGHVSTPAEESQLAGRCirVAPNGMLATISsfeDPIesVVDEIGVRHRK..RTRLTSLE..QNIEKwKSSVERWL...GWKGYALPDLDRRTSWVRIRT
  321-  668 (497.10/228.66)	TPASLPASSPAAPGPDRDilwPRALCFFHVSQDHEITGAesstpaGDHNMLRWFETPESVGFKDPLDAAQEwFLAKPDRD.KL.LEAQRKAKKAEEDAARRKEEQHNLypssplnARAGTYGDLPAVSGV..................................................................................YPTPPDGVAPGAGISQSDTPSVSGTVSNVILAPGGST.PAINLSAP................................................SDTKMEDQQLPLTSPVIP..PAPDNHNTSSGNDDLFEDMD.EDGFGGDRINDTDF.....DFFdgPDNDDVDMLDAPGLPDHNTahmeASHESQHISEPQAQDDMSDPF..AALENALATAS...EPV..VSEETDVKGKEpaTTQASSFDapETSEK.KAVVPSTLvkvTFSKEPTPPLSPSAVFKALQP
  669-  783 (82.17/24.33)	SPPNKSGSRTQQWRPSSS...QRNTQFDPVAFSRKMSMSdakyqgGRFSMHGHTEPAIKKTTPSPGPGTTP.VQAKSLRDfPL.LTKLRLA..VGMASANKIPEMTCL.......ARAASEG.LESSSDT...............................................................................................................................................................................................................................................................................................................................................................................
  866-  979 (76.72/21.12)	..................................................................................................................................sdasdedseqeeeiertsvailnslvmpakrklqsegnatplsvtsfaesmggdwhdlyalqldeanlstfepslfdwslvnFPSPAERVATGARYS...FPALLPSPSQMPDTP.TSQ.PDLNYEVP................................................EEKPPNGKDIISITQIV......TDQIVSATLDVLGEDPPaEKTFAGNAAIEMHWqtaikDVF..PTAEDCDLPTLVGI..HE............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.22|      31|      40|    1573|    1603|       2
---------------------------------------------------------------------------
 1547- 1570 (37.25/17.52)	....TT..GL...PNPYPSTSTPQSPSPNPGQQ
 1573- 1603 (56.61/31.10)	GQRSTT..SLMWTPTPQTRTTAEGLLKEVMGQF
 1614- 1644 (45.37/23.22)	GMRGTRggTVPWHVVAAKR.GVEGLGR.VGGGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.27|      42|     129|    1276|    1318|       4
---------------------------------------------------------------------------
 1276- 1318 (73.29/40.52)	GYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFrEIAKEIW
 1404- 1445 (75.97/38.33)	GVSPSDPGPGLTPAATPSADPSAADPAADPEARLV.DITDETW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.11|      21|     129|    1026|    1049|       5
---------------------------------------------------------------------------
 1026- 1049 (36.03/21.15)	WDLlppAVAFW...EPLGLSPISSPKN
 1160- 1183 (40.08/16.55)	WEL...CSAFWslfQAYGQGPPGRPEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.56|      22|      58|    1194|    1216|       7
---------------------------------------------------------------------------
 1194- 1216 (35.56/27.15)	IPIKYIASfDAPVILDPSTYFNL
 1254- 1275 (40.00/25.22)	IPFKLVAE.PAQDLLRENTYMHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26649 with Med13 domain of Kingdom Fungi
Unable to open file!