<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26644

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDHSAKRQRLDSIGRFSPASPPFDVAAKASSQTTKTLVQPRTPTSPPYSSMNPMTNGGFATTTNTTVSSDRSPQASLPMSYSHSHSATSASNQHPFPTPASTAGFMSSATVDSDGDATMEESADDDSGSLAHHRLSNHNRRDASAYTNDGRLRAAQGISGSQLFKMDKEKIETSRPHPTQNFIRLYRLEPLASSVARNDPVTGEKINKLRKSYEGHIKQMQIAGKPKATKMDGVFRNLLAIPDEIWQPNHVQNREPAKTALTPDGTALLPDFSALLDSAFAGMGAGSLPNHDAAKYKAYLGTDDAIKPKPQDAPLQRTTPFTSSAPTPTNHINRGGVRPERSGSKRAYTDATFQGYGEGFNDDYADSTGGEDTPGGMANKRRKLQFERTSHSVEVGGARR
Length401
PositionHead
OrganismPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.06
Grand average of hydropathy-0.832
Instability index48.28
Isoelectric point9.28
Molecular weight43251.20
Publications
PubMed=21067574

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26644
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.03|      18|      19|     266|     283|       1
---------------------------------------------------------------------------
  266-  283 (30.52/19.99)	GTALLPDFSALLDSAFAG
  285-  302 (32.51/21.76)	GAGSLPNHDAAKYKAYLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      17|      20|     121|     137|       2
---------------------------------------------------------------------------
  121-  137 (29.37/16.86)	EESADDDSGSL.AHHRLS
  143-  160 (24.46/12.96)	DASAYTNDGRLrAAQGIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.23|      14|      19|      67|      81|       3
---------------------------------------------------------------------------
   67-   81 (21.23/14.08)	TVSSDRSPQASlPMS
   89-  102 (26.00/13.39)	TSASNQHPFPT.PAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.74|       9|      19|     303|     313|       4
---------------------------------------------------------------------------
  303-  313 (12.86/10.89)	TDDAikPKPQD
  323-  331 (16.88/ 7.51)	TSSA..PTPTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.63|      13|     297|      39|      60|       5
---------------------------------------------------------------------------
   19-   31 (23.13/11.64)	PASPPFDVAAKAS
   44-   56 (26.50/14.09)	PTSPPYSSMNPMT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26644 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFNDDYADSTGGEDTPGGMANKRRKLQFERTSHSVEVGGARR
2) KAYLGTDDAIKPKPQDAPLQRTTPFTSSAPTPTNHINRGGVRPERSGSKRAYTDAT
3) MSDHSAKRQRLDSIGRFSPASPPFDVAAKASSQTTKTLVQPRTPTSPPYSSMNPMTNGGFATTTNTTVSSDRSPQASLPMSYSHSHSATSASNQHPFPTPASTAGFMSSATVDSDGDATMEESADDDSGSLAHHRLSNHNRRDASAYTNDGRL
360
298
1
401
353
153










Molecular Recognition Features






MoRF SequenceStartStop




1) ANKRRKLQFERTSHSVEVGGA
2) KYKAYLGTD
3) MSDHSAKRQRLDSIGRFS
4) NFIRLYRLEPL
379
296
1
182
399
304
18
192