<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26638

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHSASDAAAASRDGDTKKHAHDGSLTNGASMAIATPKGPTPDQHHEDPPEIEHVGDEQYNSLSALLLRISQESYNEMGAVLQKMADIPVGPTTNGSFANGLIAANSQGNAEANKRKKLLLLQFAQEQRAKFIKLLVLTEWGKKAAKDLTRLIDLFRWASEQAQHMEAADYKLDRIKVLSNNARENSPDIATALEVLSSGKAPWMPSLGYIPPEPVSSDEALKLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRATFVIDNELEFDVMSFVEDASEQWFLIDLRLLFTPAPTITVGSRFFMQLKLQADFVLKDKGLSGLFDFLNNFILTHKISVLRSQAVGLVRAGWAGSLKVEPVHRLLVVSYWTNRPGKKNWIEIGISSNRPKNGKVSWRGQPIPSLSTRWFRQGKEVKDANFKFDWKSLSMEKVIKLVIARHTSDILTSTKDKLKSGVMAAAHLSETEPADCALSATLGTKSTSMTLSLEPVTGNFIMRPASALSARAENAFNQGREPEKMADVITQVLAGTLHTLIQKIAQQIGWQPVARQSLRPQVVTAAVKLDVISSTLYCPRGWPSSWALAAVIDSSGESWWVFEIGSTGDSIKTAEQIKMERPDGSSLPVNRRTLASIGRVAVQLISFRATASRLARERKSCSLQTELGQVGGIESRRIARRWVLHLQTPDLLVETPGQDAWLEPDIRITCEGLRVQGQTVWHIAAGKMVKGVAADMHKLMAASPQNTFKFSEDGNFRILLSTPFAQDILGELRSRLRDVNRLRTFAATLQKREMRLGSSSLQRVQFQYGPAPYSATVNFSSEQEFSIELSPNNPHQRIHKLLTAIANDQLPSFPSLDSGDSSGLDRFCTTLVLTRPLFKVLREIEQRTPGNYCNPAIHVHSILKYRITYSNPVCTFDVGLQHKGDTVYWVLEDNLRPKDPNLLPTPERGQGHRRLDVLQARLKALFSEKGTGWFGTRNGIVADLDAIPDALQKLDQVVLSCKMDGGYVAPPPLVQQAQNQGHALGQAVAQANGTQQANMQQQQQQQARMQQQQQQQQQQQARQQQQAQHNQQQARRQQPPQQNQRGQQPNGRPNQLHMPNGRPQMQQQQQHGRGGRPGQNQNNVIEID
Length1118
PositionTail
OrganismPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.06
Grand average of hydropathy-0.469
Instability index47.17
Isoelectric point9.53
Molecular weight124584.10
Publications
PubMed=21067574

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26638
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.61|      18|      18|    1025|    1042|       1
---------------------------------------------------------------------------
 1005- 1022 (26.53/ 9.36)	QQAQNQGHALGQAVAQAN
 1025- 1042 (36.01/15.09)	QQANMQQQQQQQARMQQQ
 1045- 1062 (32.14/12.75)	QQQQQQARQQQQAQHNQQ
 1064- 1079 (23.93/ 7.79)	..ARRQQPPQQNQRGQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.84|      14|      15|     134|     147|       2
---------------------------------------------------------------------------
  117-  130 (20.21/ 9.82)	KKLLLLQFAQEQRA
  134-  147 (21.13/10.59)	KLLVLTEWGKKAAK
  151-  164 (23.51/12.59)	RLIDLFRWASEQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.53|      15|      18|     195|     211|       3
---------------------------------------------------------------------------
  195-  211 (21.54/20.07)	EVLSSGKApwMPSLGYI
  214-  228 (25.99/14.42)	EPVSSDEA..LKLLRYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.17|      11|      18|     434|     446|       4
---------------------------------------------------------------------------
  434-  446 (14.78/12.93)	ARHTSDilTSTKD
  455-  465 (19.39/10.09)	AAHLSE..TEPAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.48|      21|      21|     266|     286|       5
---------------------------------------------------------------------------
  266-  286 (36.11/24.65)	FDVMSF...VEDASEQWFLIDLRL
  288-  306 (32.27/21.20)	FTPAPT...ITVGSR..FFMQLKL
  798-  819 (24.11/13.86)	YGPAPYsatVNFSSEQEFSIEL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.61|      23|     253|     672|     726|       6
---------------------------------------------------------------------------
  371-  393 (42.92/13.71)	GKKNWIE..IGISSNRPK.NGKVSWR
  687-  712 (35.69/44.48)	GQDAWLEpdIRITCEGLRvQGQTVWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.20|      12|      21|     643|     655|      10
---------------------------------------------------------------------------
  643-  655 (17.77/16.00)	RLAReRKSCSLQT
  667-  678 (23.43/15.65)	RIAR.RWVLHLQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.55|      11|      15|     309|     320|      12
---------------------------------------------------------------------------
  309-  320 (14.39/11.81)	DFVLKDKgLSGL
  326-  336 (19.16/10.21)	NFILTHK.ISVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26638 with Med14 domain of Kingdom Fungi
Unable to open file!