<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26634

Description Uncharacterized protein (Fragment)
SequenceMTSRPGPGIHESLQNRASGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAAAAHDAARPPPRGRPPLFYTTIAQHPLDIHPHGLPYQPPANLPVPPRPGLVHLRDAAHQRRILPGGTGVKDAPKSGAPEVIVPPVYFPGGKPADLFPWSGNNAEDNLTETLVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPNTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIATIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVDGLGSCPSERLFIWLLIVSISHYWADVSCCRRRGKRLAESLLNQLDKIYRVEDVNPYLAVLHYLENTVIRLIATRPACLLLPTTWAKYSPLLVQLAERRNHPNVTQAVRRLEQRNSRLLQCSKSLPSASQTPAGRVYRILDSVDYSRPVRIEDLSFDCMEVVADAPRLIDILLRWACSCYREGSHRIYLATRLLRKWAHLGADVYDGILSHFHDMTWVATGESTTLFKIVAELVRSKTFATGRYLQWLIATG
Length616
PositionKinase
OrganismPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.335
Instability index45.86
Isoelectric point9.67
Molecular weight68901.34
Publications
PubMed=21067574

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.61|      31|      46|       4|      43|       1
---------------------------------------------------------------------------
    4-   34 (55.47/18.77)	RPGPGIHESLQNRASGVPPRTQAQRRASKPA
   51-   81 (56.14/29.52)	RPAAHHAAAAAHDAARPPPRGRPPLFYTTIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.90|      24|      52|     310|     334|       3
---------------------------------------------------------------------------
  310-  334 (43.23/36.10)	W...GRGWTSSVEQFIDGVIATIGQgDW
  362-  388 (43.67/30.68)	WivdGLGSCPSERLFIWLLIVSISH.YW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.08|      43|      50|     188|     235|       4
---------------------------------------------------------------------------
   89-  108 (24.46/ 8.20)	......................PHGL.......PY...QPP.ANLPvPPR.PGL
  188-  235 (68.76/45.06)	RPSLINNLKN.KSGLSTLSTLFVAVLekrqqTGRL...QTPNTFKP.PPR.LTL
  240-  287 (67.87/35.31)	REQWLHDLANpNTGLRRLSRTIPHGL.....TGKVlleQCLNKNIP.LPRaLWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.62|      14|      23|     121|     134|       5
---------------------------------------------------------------------------
  121-  134 (26.74/14.04)	LPGGTGVKDAPKSG
  145-  158 (27.88/14.93)	FPGGKPADLFPWSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.61|      17|     149|     392|     408|       6
---------------------------------------------------------------------------
  392-  408 (31.86/20.36)	SCCRRRGKR..LAESLLNQ
  542-  560 (26.74/15.91)	SCYREGSHRiyLATRLLRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26634 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIHPHGLPYQPPANLPVPPRPGLVHLRDAAHQRRILPGGTGVKDAPKSGAPEVIVPP
2) MTSRPGPGIHESLQNRASGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAAAAHDAARPPPRGRPPLFYTTIAQ
3) NLTETLVKAGVSNKPQIMNESNTARPSLINNL
86
1
164
142
82
195










Molecular Recognition Features






MoRF SequenceStartStop




NANANA