<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26630

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDDMLNTQFARVEKALTTLVDSIAAYNPAPQAAIDLFTADDELSEGLDQLAKHQANHVRIQFLRAEADALEEQLKNSVKKLAELRHDLFNTPVTTFSQDSRAVPFDELLQYATNISRYTVPPTYRDPVPVPDKDKEEEDIASTGLPTNGLNTPAIVPETTEPTNDGVQAQKEGEDADATAPEVTAEEEEWLKKLKASNLPWYPWPNNDRIRAGNLYSLQYWREKGKDLDTFNIPAYMEEERLKALGQNLDSEPSPAKPLEENRDRGAPRPAIKLGVFTGLDDMED
Length285
PositionMiddle
OrganismPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.739
Instability index44.94
Isoelectric point4.48
Molecular weight31952.02
Publications
PubMed=21067574

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26630
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.93|      35|      49|     168|     205|       1
---------------------------------------------------------------------------
  168-  205 (57.31/40.20)	QAQKE.GEDADA.TAPEVTaeEEEWLKKLkASNLPWYPWP
  219-  255 (53.62/28.97)	QYWREkGKDLDTfNIPAYM..EEERLKAL.GQNLDSEPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.35|      23|      24|      29|      52|       2
---------------------------------------------------------------------------
   29-   51 (37.76/25.48)	APQAAIDLFTAD.DELSEGL....DQLA
   55-   82 (26.59/11.75)	ANHVRIQFLRAEaDALEEQLknsvKKLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.53|      19|      23|     121|     139|       3
---------------------------------------------------------------------------
  121-  139 (35.34/20.97)	PPT.YRDPVPVPDKDKEEED
  146-  165 (29.20/16.08)	PTNgLNTPAIVPETTEPTND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26630 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EERLKALGQNLDSEPSPAKPLEENRDRGAP
2) VPPTYRDPVPVPDKDKEEEDIASTGLPTNGLNTPAIVPETTEPTNDGVQAQKEGEDADATAPEVTAEEEEW
239
120
268
190










Molecular Recognition Features






MoRF SequenceStartStop




1) AGNLYSLQYWR
2) LPWYPW
3) PLEENRDRGAPRPAIKLGVFTGLDDMED
212
199
258
222
204
285