Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKVIDARFERVEKALAILIESVSKYHPHPKQALDLYEADNDLAKGLDEVQAHQNNHIRLQQLRATTSSLDTQIRETLQSLATTRKDITTTQITVYPDGPKYPVKYDELLNYARRISKTTLPPAALINGGSLTTGGGTPGPDLNASMTTNPNTPGANGLQSQPVSAVPTPSQSQTPGPSGAPNSSPLHDAHQGIQQTAATSGATSLPDGLRNHLNPHFNASFIPWPNEFQIRSGAMAVYQDLSDKGIDPRGYDPQQIAEAKRKEEEERRAREEQEKLENERKDREYREKMEKIRREQQEAYRRDSVAAGAGASSAGKSKQFQFTSLMDDDDDDE |
Length | 334 |
Position | Middle |
Organism | Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.934 |
Instability index | 47.15 |
Isoelectric point | 5.49 |
Molecular weight | 36902.22 |
Publications | PubMed=22885923 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26627 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 84.36| 18| 20| 146| 163| 1 --------------------------------------------------------------------------- 117- 134 (27.61/12.43) SKTTLPP...AALINGG.SLTT 146- 163 (34.26/16.92) SMTTNPN...TPGANGL.QSQP 165- 186 (22.48/ 8.97) SAVPTPSqsqTPGPSGApNSSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 59.00| 19| 32| 250| 269| 3 --------------------------------------------------------------------------- 250- 269 (26.77/18.55) RGYDpQQIAEAKRKEEEERR 284- 302 (32.22/17.41) REYR.EKMEKIRREQQEAYR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGKSKQFQFTSLMDDDDDDE 2) KIRREQQEAYRRDSVAAGA | 315 292 | 334 310 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab