<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26623

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIVYRVYEPSQEHAQTFPSAAADVETELRNRGHIVYYDATRRVLWYFYISSKDAVSGDESDGILGNSVSIAGATLLTADEGSFEPVSLFKGRAPGQQPANTPTSSSSSNSALDLSLRNQQTGISVLPTSSDPEPKGTGLATLPDIYEQFITAILSTISAAFCSRVSAIPLNHRTVLLPSKVMRDGQAERALDTEAAVVGTFRIYLTTTGALVMSLSVSCCEGLLSVNEPSSPSQLVLGSQILAAPFGVLANYQGFVGGGLSYPELGLGQTPDTQLWRGADARSSQWRDTCIKIFQSRGLSPILLQSCPWIALQMLRRKSGEHKIEGKMTPFPSTLATISWPAVLCFRKKSVMLARNSGLGDPVLLAQDETSDFLNEARTWFQLGTERDEKVSKRKKEREIAASREAVAAVPAQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGAPGTTMAVVDIDTTMTDTGTHDVSAMNTSQHNEAYGDGWHSSDSKRDRADSFLAGDNDNLFGDMGPDMFGDTDITDADFSFFDEEGGNDLDLSGLPDLGMPDAPPAPPAIPAPVPEPAKLILPVEEAKPVLSPPIFAKPELKHARSTLLDEGKQRSSVEKTAGVKRESSPFDPDTVYKRVRASLADIRSAQQRTPARKGSVFDSVDFDPVLPLVNKKYEQGGRFDCPPIFQGRSQDASKQTVSQGPPTTDYLRRHGKQRKTLRQPERTNALIRTITGNLENSPLVASPGKGDDLASDADDVSLVSDQDDSSTSEDEPASPFKSSIRRLNLDDDVASHVTSLKDIESVDDSDPALALDLPKLAKAEASETLIPKYFEDAESLPIYLSLPDEDAITIAQIVTEQAATGSLRIRDALANTLNTAIVSDTRRQLSSLGRTALQALREVIPPCLGEFNACNFKGLVEVPDVPLIGPPSRLHPRPANPRDNAEPPKPNNLFQIPAPHMELRRAEARLSVLPVSVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLPSSSKVADGLVPFEADKVATSPGTVSPHIVAGLGDRMEALNQGLLLANAKEKNFVIYFVYPPDHPGSIVEACTAFQQLFEMHKRSLSDKRQTPTNELVLQLVPLDFLTSSKGMVEPTPNDAIKLAIETYDRCTLFGGPMPSPAIILEQSFPRGIDFKLSATSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGSQQMTASYNLGRKGKALSTSLNDVCHEIWETTHDLISKWKVHWRVVISKCGFMDAQEIGFWQGLAQTESVATVSLTLISVDTNPSMQLVPPAIKVSATAPSAFYTTPVSTPQASIVSPEQSGTPVTPMKENNPANAATPGGTPGDGNAEPAEGDAILLDVTDQSWGAVLSHRLSNSYSLGELNPALISGYLVKRGGTKLEDPPVVMEVNIVHADNNPRMYEGLMREMLTYFRGLGTLARARGVIDRGTDVRPWHIAAAEKGVRALYLLM
Length1515
PositionKinase
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.06
Grand average of hydropathy-0.292
Instability index48.31
Isoelectric point5.10
Molecular weight163738.49
Publications
PubMed=22885923

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26623
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     406.03|     140|     385|     582|     966|       1
---------------------------------------------------------------------------
  790-  947 (192.87/359.60)	TSEDEPASPFKSSIRRL.....NLDDDVASHVTSLKDIesVDDSDPAlALDLpKLAkAEASETLIpkyFEDAESLPIYLSLPDEDAITIAQIVTE..QAATGSL...RIRDALANTLNTAI..VSDTRRQLSSlgrtalqalREVIPPClGEFNACN...FKGLVEVPDVPLI
 1159- 1319 (213.16/60.53)	TSSKGMVEPTPNDAIKLaietyDRCTLFGGPMPSPAII..LEQSFPR.GIDF.KLS.ATSSSSLM...HENTCIHIAYAQSIDERWITAAWTDNRgsQQMTASYnlgRKGKALSTSLNDVCheIWETTHDLIS...kwkvhwRVVISKC.GFMDAQEigfWQGLAQTESVATV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     415.98|     133|     385|     959|    1101|       2
---------------------------------------------------------------------------
  582-  715 (165.11/99.84)	........PPAPP...AIPAPVPE....PAKL.IL..PVeeakpvlSPPIFAK.PELKHARS...TllDEGKQRSSVEKTAGVKRESSPF.D.PDTVYKRVR.ASLADIRSAQQrtpARKGSV.F..DSVDFDP..VLPLVNKKYeqGGRFDcpPIFQGR..SQDA
  716-  789 (52.92/23.57)	SKQTVSQgPPTTDYLRRHGKQRKTLRQPE.RTNALirTI.......TGNLENSpLVASPGKGddlA..SDADDVSLVSDQDDSS..................................................................................
  959- 1101 (197.94/153.96)	NPRDNAE.PPKPNNLFQIPAPHMELRRAEARLSVL..PV.......SVQFWES.LGLGPAQG...T..KDVNVVCVFPHWDGMSDVAAAFlDrMRNVYELLKlGSFERLPSSSK...VADGLVpFeaDKVATSPgtVSPHIVAGL..GDRME..ALNQGLllANAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.19|      19|      30|     318|     336|       3
---------------------------------------------------------------------------
  318-  336 (35.95/18.84)	PILLQSCPWIALQMLRRKS
  349-  367 (35.24/18.34)	PSTLATISWPAVLCFRKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.85|      28|      30|     444|     473|       4
---------------------------------------------------------------------------
  445-  473 (48.73/30.04)	NAAAAGTMYPTPPDGVQNPLgITPSMDGT
 1342- 1369 (49.11/21.76)	SATAPSAFYTTPVSTPQASI.VSPEQSGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26623 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FDCPPIFQGRSQDASKQTVSQGPPTTDYLRRHGKQRKTLRQPERTNALIRTITGNLENSPLVASPGKGDDLASDADDVSLVSDQDDSSTSEDEPASPFKSSIR
2) GTERDEKVSKRKKEREIAASREAVAAVPAQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGAPGTTMAVVDIDTTMTDTGTHDVSAMNTSQHNEAYGDGWHSSDSKRDRADSFLAGDNDNLFGDMGPDMF
3) LDLSGLPDLGMPDAPPAPPAIPAPVPEPAKLILPV
4) LKHARSTLLDEGKQRSSVEKTAGVKRESSPFDPDTVYK
5) STPQASIVSPEQSGTPVTPMKENNPANAATPGGTPGDGNAEPAEGDAI
702
401
568
619
1355
804
547
602
656
1402










Molecular Recognition Features






MoRF SequenceStartStop




1) DITDADFSFFD
2) VYKRVR
551
654
561
659