<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26621

Description Transcription mediator subunit Med12
SequenceMGVQPRPPQQRTVSSSGLSVQRPTHQRTLSAQYLPQSPVRKENPIDLTGDDAAVAQNRYGTLPRRGGSRLKLELSNDAMLAQHPITDSPKTLTPSRLMPKNDPSNLVEMASPSSAKGQPIDADNPPMPMPKRRQRFVAPSAVKDSPAPTVAIKKDGRPKAWHFETPAAAPRYAPFNKQRNDATVKPGFGGSGTGTRDTSEIGYADFFPWNGNHPEDQYSETVIKTGYYDKPPASSASETSSAKAVLFPALKHKSGLNLLSSIFVGVLNQRKLNGQILSPSTFKPPPRVTLTDTKREIWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILITQIYWKDLLRLRKYGRRLVNALLGHLHTIHTDPDRDILAQLSARLATLLTPLLSAHPDNFVSPATWFKYRDALLASIPTDHEFAQTAYKSINIRNEQLVASASNSQPANRQILVKHLDSTFTTLYSPDLAAQCWAVSEDKGMIVRTLLEWCTSPHRPGAAKVYITASLLRAWVAAGVDVTTAVLEYLSSNPPTETNSKRVFHRLMSEIVRSGDFQLQGYIFWLIARGGLRKPADTEADGSCATRLLVDLPLHALNSTSRTTRASLLRRASYDVNDEAEDISTALKCIEHALGLPLPPGDPMLQRKPVPVGKLCRLIANSNRALQTEVGARLVQIFTTEIVMTKNGPQVSPAMFNFTRAVLEAASDFSALAEIIKLVVRASNPEILASCADTLNVHLPIFAAFGGPKEMFDLLMERLKAVSEEQGPAARPLLASLASLAVRLPGFTNTASYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTGGTSVDRPTMDRLFQTVVGRLESSWSNSPDRQRAYSALLGRLRIFDTQHFDVRMTDWVHHISALKARPALVDIYPLLISMGCLTLPIVLTTTSIDTGRIALNPSGPTNSTTTYMQEVLRLTTMPLTVKTTLTPEETYRFYIQQQVAPRQNHKDMVLLVRNALVEYSRLQGAVDPALLPLTNPSFTNSVLELLKFLVLRDPPSVVQALGTKTPEPALTNLFAQITSKLLLPDASDESPLTFETVLELANEFTLPFCQLKLSIGLSADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEHLKKQAHLRFLGLFPSQKNPPVSDPLSLESTQLAGSLLSVVEAILRGRPAVRTSQLTSGMVEKLAELWEILAAGDDDKRELRTSILRYWLPALLRFITLHTTANEPVSAAAQAQATNNMKPPVNAAAFEIRARILIILSGLTLELDTLALQDPQTGRILSQKVFDLALLLIDTLPEDSRLQCVRVLLTGGTMQNPASSDARLQYLFSHMPPQIEQFVLAHRQQPATQQIGPPRQKIPISMQGTGKLTPFVYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1531
PositionKinase
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index43.24
Isoelectric point8.96
Molecular weight169241.15
Publications
PubMed=22885923

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26621
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.12|      15|      18|       1|      18|       1
---------------------------------------------------------------------------
    3-   18 (24.23/23.04)	VQpRPPQQRTVSSSGL
   20-   34 (28.88/12.72)	VQ.RPTHQRTLSAQYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.74|      14|      18|     945|     958|       2
---------------------------------------------------------------------------
  760-  774 (19.02/10.58)	ANSNRALQTEVGaRL
  945-  958 (25.43/17.04)	PTMDRLFQTVVG.RL
  966-  979 (23.30/14.89)	PDRQRAYSALLG.RL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.90|      15|      19|    1386|    1403|       3
---------------------------------------------------------------------------
 1386- 1401 (19.95/10.09)	ILSGLTLELdTLALQD
 1407- 1421 (23.95/11.87)	ILSQKVFDL.ALLLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.25|      15|      17|     317|     333|       5
---------------------------------------------------------------------------
  317-  333 (23.49/18.64)	PHgiRGKVLLDHCLNKN
  335-  349 (27.76/15.21)	PT..ERAVWLVKCVGAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     541.85|     133|     365|     793|     942|       8
---------------------------------------------------------------------------
  506-  639 (174.63/98.82)	PAtWFKYRDALLASIPTDHEFAQTAYKSINI.....RNEQLVASASNSqpanrqiLVKHLdSTFTTLYSP....D.LAAQCWAVSEDKGMIVRTLLEWCTS..PHRPGAAKvyiTASLLRAWV.....AAGVDVTT.....AVLEYLSSN.......PPTETN
  656-  715 (70.56/55.76)	................DFQLQGYIFWLIARGglrkpADTEADGSCATR.......LLVDL.PLHALNSTSR......................................TT...RASLLRR......................................ASYD
  793-  927 (220.72/133.93)	PA.MFNFTRAVLEAASDFSALAEIIKLVVRA.....SNPEILASCADT.......LNVHL.PIFAAFGGPKEMFDLLMERLKAVSEEQGPAARPLLASLASlaVRLPGFTN...TASYLRQQLHQCDRNNPIDACS.....PVSDNMTAQ......LQDAEGE
 1089- 1172 (75.94/37.16)	......................................................................KDMVLLVRNALVEYSRLQG.AVDPALLPLTN.....PSFTN...SVLELLKFLVLRDPPSVVQALGtktpePALTNLFAQitskllLPDASDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.83|      12|      16|     286|     297|      10
---------------------------------------------------------------------------
  286-  297 (20.13/11.15)	PRVTLTDTKREI
  305-  316 (19.70/10.74)	PSISLRRLSRTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      16|      16|     459|     474|      11
---------------------------------------------------------------------------
  459-  474 (27.47/19.49)	RRLVNALLGHLHTIHT
  478-  493 (24.30/16.25)	RDILAQLSARLATLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.84|       8|      16|      94|     103|      12
---------------------------------------------------------------------------
   94-  103 (12.15/10.24)	PSRlmPKNDP
  112-  119 (15.69/ 6.04)	PSS..AKGQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26621 with Med12 domain of Kingdom Fungi
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