<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26618

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVRGVQRAALEQWSEFIAKSLSHRIDPEKFESYVPFLQVKHPLPPVAVADLFLRPQPHNHESLDPRVPRYLQVLSDLNYIDTASILKSLYRYSTSRAHSRDAAQPAIGEAQPLNLPRWGSSYAAEEVMFYRLTKAVAQGIAIQNTGTGLEIASIMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKALSKPEAQGTRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDDEKSKSNAEIEDLFDSTVALDNFVISELPIVNSRAGLYIYLNAALVGRPLVDDLAIFNYLNNRYQGDVQSTTVDLILASFDVLANAASRNEGNQAAHLLRSFLMNKLPILIESLSKHMYGPVNAEYCITEALGRVDTTTFPTLSSMFDETRSNNPFTDSVREEFCWACCLHGLVRESSIETLLGETPYQSLPAGGRYVKENLVAECLADPERMQALIGELDNKDGNAGAVCQALTEVMGQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPGTILHPLCDLLDNWKYEEDQGEYQPVYEEFGSILLLVMAFAYRYGLSASDMGVASPDSFVSKLLGQGHQSRPFDELSDQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLAEESLRGGIEYLVDTFLLPSLVVAITYLANSLWVERSDCQKAIVRVLNSVLAPTSISNEAQAMLTSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDAWSLGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVALKLLGAKRLLQLLYEDIRQQTDTGSGSIIYDVATAIVCAPDVANTPPNSVNFLDNSGNMPAPVQRKLTLREVLKSDAEDCKRLQKTDMNLAEIVVRLHRKVESQMAVSQAQAIQADTMLQTDLGLGLDTGAGSLDDAMAAAAANVGQGDGMSVDNVSLDLGLGGVGGDMGLGGSSNNGGGSLDLGTDDIFGALGASDDFQWDNMDLS
Length1035
PositionTail
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.088
Instability index40.18
Isoelectric point4.81
Molecular weight113085.16
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.92|      18|      23|     985|    1004|       2
---------------------------------------------------------------------------
  985- 1004 (28.17/17.77)	SLDLGLGGVGGdmGLGGSSN
 1009- 1026 (31.75/14.53)	SLDLGTDDIFG..ALGASDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.69|      28|      33|      28|      55|       3
---------------------------------------------------------------------------
   28-   55 (51.48/33.94)	RIDPEKFES...YVP.FLQVKHPLPPVAVADL
   58-   89 (42.21/26.51)	RPQPHNHESldpRVPrYLQVLSDLNYIDTASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.31|      32|      37|     375|     411|       4
---------------------------------------------------------------------------
  375-  406 (57.19/44.57)	ESLSKHMY.GPVNAEYCITEAL.GRVDTTTFPTL
  412-  445 (50.12/26.86)	ETRSNNPFtDSVREEFCWACCLhGLVRESSIETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.32|      16|      26|     172|     197|       5
---------------------------------------------------------------------------
  172-  190 (21.74/38.66)	AFTvDVMGQLHNSqvREEM
  496-  511 (30.58/15.05)	ALT.EVMGQLCRN..KETM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.13|      12|      26|     686|     698|       8
---------------------------------------------------------------------------
  686-  698 (16.32/13.11)	LPSlVVAITYLAN
  715-  726 (18.81/ 9.77)	LNS.VLAPTSISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.23|      20|      27|     513|     539|      10
---------------------------------------------------------------------------
  513-  539 (29.95/29.73)	LKLLCSQLAQ..........KPlsldvmlMFEKPGTI
  540-  569 (30.29/15.79)	LHPLCDLLDNwkyeedqgeyQP.......VYEEFGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.20|      20|      27|     610|     629|      11
---------------------------------------------------------------------------
  610-  629 (37.38/26.98)	DEL.SDQEKGHLNGWIHGLFD
  637-  657 (31.82/21.74)	DELmSSCPPQDFYLLVSTLFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.53|      20|      37|     763|     782|      12
---------------------------------------------------------------------------
  746-  761 (19.11/ 8.34)	SLRAYQRSD.P.KSQEVE....
  763-  782 (32.90/19.53)	LLKAIKDSI.P.LSRRTGAADH
  801-  822 (28.52/15.98)	LQQLVQWSIhPtMDRMPPAYTH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26618 with Med5 domain of Kingdom Fungi
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