<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26617

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFHPQTPQSPSQFSPGTSDLASSMNSTVPSTTTTLPTPAHSVNGSASQPSDMSQDIVMGDDTPHKRKRPLEDLGDREQKKVHIEDSKTGIEALHLDVGEKYLLCQTPHHERLPRITEDLFEMFNLTGIAAEVAREKPNGEKNALRKTYKGQIKKLGILGRFDSVAQDWDAPRESDGDKKREAYHGFRELLEIPDAEFWGTRQDPITNGLSSAVKFNLSKATAMAKGPIPAKDWDSSVLGDIPPGGLDALKQGLAGKATAPGTPSATTPNPFMRKQQQGPPGAVRPQRTTKKRGYGENTYEGYGEGFPDDGYSTGDGDDRGGQKRRKKVGSAAALPFMSLSDPLQDGGNGQVFPNAMRPQGYGAVGA
Length367
PositionHead
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.06
Grand average of hydropathy-0.822
Instability index42.81
Isoelectric point6.73
Molecular weight39599.64
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26617
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.60|      29|      35|     193|     223|       1
---------------------------------------------------------------------------
  193-  223 (45.38/32.62)	IPdAEFWGTR..QDPITNGLsSAVKFNLS.KATA
  229-  260 (45.22/24.23)	IP.AKDWDSSvlGDIPPGGL.DALKQGLAgKATA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.65|      14|      35|     135|     151|       2
---------------------------------------------------------------------------
  135-  151 (16.96/19.72)	REKpNGEKNalRKTYKG
  173-  186 (26.69/15.45)	RES.DGDKK..REAYHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.57|      35|      65|     262|     296|       3
---------------------------------------------------------------------------
  262-  296 (65.80/27.98)	GTPSATTPNPFMR...KQQQGPPGAVRPQRTTKKRGYG
  302-  328 (39.63/14.40)	GYGEGFPDDGYST...GDGDDRGG....QKRRKK....
  330-  363 (52.14/20.89)	GSAAAL...PFMSlsdPLQDGGNGQVFPN.AMRPQGYG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26617 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGLDALKQGLAGKATAPGTPSATTPNPFMRKQQQGPPGAVRPQRTTKKRGYGENTYEGYGEGFPDDGYSTGDGDDRGGQKRRKKVGSAAALPFMSLSDPLQDGGNGQVFPNAMRPQGYGAVGA
2) MSFHPQTPQSPSQFSPGTSDLASSMNSTVPSTTTTLPTPAHSVNGSASQPSDMSQDIVMGDDTPHKRKRPLEDLGDREQKKVHIEDSKTG
245
1
367
90










Molecular Recognition Features






MoRF SequenceStartStop




1) KRRKKVGSAAALPFMSLS
324
341