Description | RNA polymerase II transcription mediator |
Sequence | MGDRLTQLQDAVDQLAQQFVASFHFVHRRHDLELLGPNDKIREVKQDPEQKEVDPLPPDEFKDGLAELARDLIIKEQQIEVLISTLPGLDSSEADQERYIQELEDELKVAEAQRQDAIKEKDQILTKLDEVIRGIRRP |
Length | 138 |
Position | Middle |
Organism | Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.736 |
Instability index | 41.55 |
Isoelectric point | 4.61 |
Molecular weight | 15947.73 |
Publications | PubMed=22885923 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP26615 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.06| 19| 43| 59| 79| 1 --------------------------------------------------------------------------- 59- 79 (27.89/25.18) DEFKdgLAELARDLIIKEQ.QI 105- 124 (28.16/17.64) DELK..VAEAQRQDAIKEKdQI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DKIREVKQDPEQKEVDPLPPDEFKDGLAELARDLIIKEQQIEVLISTLPGLDSSEADQERYIQELEDELKVAEAQR 2) IKEKDQILT 3) IRGIR | 39 118 132 | 114 126 136 |
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