<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26613

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGSSMPFSSLHPVPTGGRKPKSLGEFIARVQSERGFRNVTEESLKEEVENQKNGDAEVKDEDTAMSDGNADDEEPPDAGAARMEVLRNIDVAQNAALMTLDFISLLLSKESPAQAGVTLSQALRDWTGIGTLGIAKREDSEEQKQRDADRAKDNRDVSLGWALLDIQTTKESADKAASHLSKEVEREAKYWDQVLAVHRAGWSMCRLPAERHTLGVRFGFSEASPEFRNSSLAPLRRGDDGTALLQHGRVGAGSQRLSITVSRSGETTGRLAIGSSVPDSAHLPDRVLEARNTIFAQELWHELHREAHSLASYGVRANNDSITFNPASGPSLTLELETLDGGAPAVGASTEDNVLAEATHLGLHILLSHAHRLNELQRLRPTPPHQRRNQTQSQYHLLRPIVAKILYDRSVEQVTSFAGDLTRVLRRAGVHAASFTLSTPPFPTADLKNTSGGASNRPNASQALTNMLTSPADFQVELTLTPTARLQIRGRTFLLPLTTTQFQLQLLPSIAEPTSAEPASSSLQASYPPSRDPYPDFPSVQRYVASAAAHALTDFAMSFIPATPANLSEPAHGEWSKSVRGTAIRDMDTETREIRFDVLSNDHEGRLTLQIGAAWRAGDKPLVKRWAWPAVGEGAGKSATQPHVGEIVAAVVQSKEI
Length659
PositionHead
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.05
Grand average of hydropathy-0.451
Instability index44.74
Isoelectric point5.96
Molecular weight71555.02
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     338.13|      57|      57|     410|     466|       1
---------------------------------------------------------------------------
  242-  286 (46.14/17.74)	.............DGT.A..LLQHGRVGA.GS...........Q..RLSITVSRSGETTGRLAIGSS.......VPDSAHLP
  287-  352 (54.33/22.07)	DRVLEaRNTIFAQELW.H..ELHREAHSL.ASygvranndsitF..NPASGPSLTLELETLDGGAPA.......VGAST...
  354-  408 (39.97/14.47)	....D.NVLAEATHLG.LhiLLSHA..HR.LN...........E..LQRLRPTPPHQRRNQT.....qsqyhllRPIVAKIL
  410-  466 (87.23/39.50)	DRSVE.QVTSFAGDLT.R..VLRRAGVHA.AS...........F..TLSTPPFPTADLKNTSGGASN.......RPNASQAL
  468-  525 (60.25/25.21)	N.MLT.SPADFQVELTlT..PTARLQIRG.RT...........FllPLTTTQFQLQLLPSIAEPTSA.......EP.ASSSL
  530-  575 (50.21/19.89)	PPSRD.PYPDFPS.VQ.R..YVASAAAHAlTD...........F..AMSFIPATPANLSEPAHG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.17|      18|      24|     134|     153|       3
---------------------------------------------------------------------------
  134-  153 (21.88/23.36)	LGIAkREDSEEQKQrDADRA
  161-  178 (31.29/20.79)	LGWA.LLDIQTTKE.SADKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.77|      10|      16|      57|      66|       5
---------------------------------------------------------------------------
   57-   66 (16.53/ 8.34)	DAEVKDEDTA
   74-   83 (18.24/ 9.95)	DEEPPDAGAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26613 with Med17 domain of Kingdom Fungi
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