<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26603

Description CRE-DPY-22 protein
SequenceMPSTSEIESNEGSSEEDDAYPENGVPSWFDTHSGERILRKSNTRMGTADVYKQNKNQEEDMLTTERLKKGYQMPVTQYELQSLVFNASENKLTRLDRAQKRTQSMIASIIHKKGEYNMNYDRDRKVTKDSLPRFAVYHYKRILQDRVKFFSALSRGSPLQYLSQKIPSFKKKEFLFHEFYDYNVPFDRALWCVKLVSIIGFASKTQKKTLLDVATLELSQACGKTTNHLLHHLVKNMKEESGYAEACRMWKYKTKFMKIMFRDGVLDKQEFLNDLTEAFNIFFIRGSIFKDDILQKFMAYFISFSEDISSNLILSRRASTLLCQALGILSDTEDMRRKFEAYKAENEDEFDENGTWFAAGKPIPIKGREDVISDSTSVSSVHTEDLIDFFDELPDEPYFEDEDDERTPEERAEEIYEQREAWKEEIAKRTAERQAEIDKEKEAAAVNRRTIKQEKIDSSYDRSMGTTSHSSFMVHIKEEPMDYDEYSMAQVSYPVLLPPPPPPPVPKRFLQPYNENEPEFSWEEPTEPNVRYIRENEVTPPPAESDENKMEASSPVVEYEPIPLKPLYSLPSKKYPEGHEFSHLKQKPRPPCPIIGRYGFLTFPLWQQLGGSAIDPDNEDVMDFSNPTPPEAPPPAPPVEFVSSPSESPAPENEKEDEDSEKKDDDKEESEKSKEKKDEDKSSEDHTNDLDVPVDPASKRNSTTNSKDDENDEASKEAGSEKSPKASKADEETEATEKDKDADSAEKTDKDGEATENPPIDMSTIVIPELNLDFPDPFILAEPMELDPTYTSDNLIIPVDDDYMDVDQPEMAELPVADQEDDCMIIAVQEKKVDEDDCVVIAVVEPEKEKTPEVVEEPVSEPEKASMETPAPMETSVHMDTTALIETIPPIEHIPPMEINAPMVMPQKETTSERRISDGIVVPPMTPEEREEVKLAAKKELEKGQEIHAIAKEIRLRALRDKEWENKTGTHPGFKEYDYTTMMEPIYLMSAMVQYLACVTPESFVWNNLVIQQEPRRHKILPQLCGSPLDYLPCDLYELPVPEGNEEALDTLRLRHLEIVRRSQAAEEKWLPNGADVLQYGRIIDTCVDVIGVMDNIDVEKPDAIPNAANRLFKFREKFAKEEALLRSKLMFKWCITDEREGSFRAAYIAKLLRFGMDHGSENTIGGWQPMDLFFNFMVTEGPKPGIPMYQKQFDAIVAIMIEMMREKIFSITDIIQELEKEMDLDYNAPLMARQRKQKLPKIPKQFKKEQVQDETKLIQFTTEYTPKRLFMGRKLDLLEKMIIVLPQLDVNEDTDEFRIRRLLLFGIKPAGNYYFRRIRAIYKNIAKEFETKSYIHFNRHSKVTTLHKKLNQTRLEELLRQFRAQTYYDQHIILERLVYNYIDGIGAFLEKSSDKVPAPEIVNVICEMYEFSMDISSIFDFFEMAVPFLKSVDEMIAQLRMDILPDMYYAETGFIFVSFFMKHWQRFLLHPNACGIVNQCYHLIEDMIRADDHLITGWGRTIAVFAFHARKAITAAGLQTEPFDAKDQYFWRVFPNTQQVHMDVNCFNEEFAACKLKLKGAALRYDSYSDFKWIVHNLKPNTKKVPPSKRPNARYSFVIRAFIEARKHGRNFDRLNELANYCANVTANDPPLSEYWIGAIKGLCCLSCHDTFPFKEMGQFIDISDCSTHYSFTTFISCLAGKSAFYIPRLLAELAKHVFPLMLGTHGRLTSQKTRDVRRKVTSKTTESRNLSEAEPGVCLCLLIIAGLCCAGDEPFGLAVHYRGIEKKKKRFKNTADERILHLFHWFEMDNAMFRALGHISQLLEALQPRFRDANLILPSVFQIKNPQKILSDSHREKAPYRPQFLFNIAKTVLFTICEQDWVTLRMFRFVKSRRMEAFNQDKLKQNCLGQQILRLSLRRITERDNVQKLFEAHKISKKVTVDKVLSFMNIWNFRATLFDLTLMIKEISPDANSKYAQQGAIAADALMSEIGKCCRDMFLTAYKTNIKMPNLKTLIDFRFSDINKYWLIAPLVRMCPKPTNIPVAHTNSTIGTVAAKFLKEAAMLMDTRPTTPKDRLLQCSWAMSKIPFINMILTCLRCEKSQQSKDGFLQALYVQLQREIHRDHHKRSDWTNRPEHRDCTVLRMNLITYIYKEILKPTHVEPWGLLIFQLMYHGIINQAREKLVFETCYDMLHHMVLWTLVEGDNMNTHDRYGSIRVRWPQYAGLMKKIRKEVQDRYIDPSRRSLLRFIPIGKVQMTSVSYKKFQMKNNNSPKSSKKYISGEGLKNGRYAYLPEEKVKTNAFDHILDTPEVIQKGGWRFRNFQTTRLDKVAKPIQSVLRPLIAHKHMLEFNRPQLIMSDNMFDDVFLSPPDIEITKVVDPPTPTNEEEEESGKKKADTDKTPEKADEAKKTDEESKTDEEKKKDEKEGEKSAEEADADKDKDKETDKEKEKTAEGATKSDEVVASEAEKAKTAEAEATPTPATEAKEGDTSTPKPAPVARSSPATRGRGGGRKRNSGARAGGPRAKRANSKADAKADAAATAGWTGGNTSSSGGSGGNYHAAMRANQPPMSNGSSDETKVNIRNMLNRKQEKRNSIADANAAAAVAAAAAANAAAAAAATSNAATTSTSSASAVNPAVPGSTAPVAQTQQLPGMSTDNMPGLMGQHQQSQQGMNQPMHQQPPPTYTANGLTRLTMPTYGQFATPNPGPLNPMTHRASAAISAEDRKKIMEEQMVMKLQQQQQIIEQQRQVREAREREAREHQERMAQIEQQKQEERKRAIAESNRLIEAQRLAKEQEEQRRREEQLRIQEEARQAFLAEQRRQQEEMRRREAEERARREAEEQRIRLQREAEERERERLRQEAERQRREAEERERLRQEQERIRLEMEEKARREKEEAMRLEQERKEQEAARAREVAAAAAAAAREQEHRARLEQQHRLNQQNQYMNQQTASYGQQQPQGQPPSYQQSSYQNPTGYPQQAQQPNQPPAYQQPSHGHQQMQPAQQQHQPPAYQQGNNQMQMNMHQQQQQQQQQQQIRQQATAQPQFGNQGGMNPQAQQQAYPGYSQQLGQTQAGQQGIPQQQQQRNPFGAQPEMQQPGGAKMLMPTKPNEAHAQQYQHTQNQMALSQKEKEKQYFQAKNAQAGQATGQNPRFGDATAGNASGFGRNMSFGQQQQQPNAPDFPATAQVPPTNPTRLLPGPTVNPNPMQVQQTAMQNYQQQQPVLGQPAPMQPGGPTGQQQPAAQQQQYNRPMHTTPTPDMSVRPTQPGSMGQMQNRMGPGSGTQGYVQPGQNVSGGYPQAQQPGQTAYPQQQTNYAASNPQMSQHQQPAQNMNQPAQAQSQQQNPQQAQNPGQYARPTQEGAYSQQGYNQPAAAQNYQRPEQQQPASQNQWPAQTQQANQMRQQPAQQAQPQQQAQFGRTEQQQQQYQQAQAQTQQAQQTKNPMAPQNASYRGGFPAQQQQQGYEQQPAQAPVHQNPPIHHQQQPNPQTTPQYPQPPQQQPSQQPVHQQQQPQQQQNRYSGYAGSNASSNILNQSMEESGLNQGYTSTNTSSQQSSSSHMQQNAYGMQQNQMHQQQMTQPGQQPQQPQQQSRMSQPGMGQPGMGQSTMGQPGMVQPGMGQPGMSRSGMSGMGQPVPQQVQQTQPIQPAQQQQPQAQRGMNPMGGAQLPPYSMGQQQQQATQQQQQEHYRRMQEAQQLQLQQQQQQQRTAQAQAAQAAQAQAQAQAQAQAQAQAQQAQQNAMGIPQQPAAQQQMQGGYGNQMQQFPSLQHRAQGPQAQGMGAMGAQQQVQQPAANQYYHPQQQPDQRMQQQQQPQQPGQQQQQHGYMGQYPNQQPHQY
Length3817
PositionKinase
OrganismCaenorhabditis remanei (Caenorhabditis vulgaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.910
Instability index57.76
Isoelectric point6.25
Molecular weight435359.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	IEA:EnsemblMetazoa
negative regulation of vulval development	GO:0040027	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.81|      13|      16|    2831|    2846|       1
---------------------------------------------------------------------------
 2732- 2747 (12.14/ 6.70)	VREA....REREarEhQERM
 2842- 2858 (19.67/ 8.85)	RQEAerqrREAE..E.RERL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     372.68|      26|      26|    2935|    2960|       2
---------------------------------------------------------------------------
 2935- 2960 (58.01/22.90)	Y...GQQQP..Q.G.Q.PP.SYQQSSYQNPTGYPQ
 2961- 2980 (32.59/ 8.72)	....QAQQP....N.Q.PP.AYQQPSH....GHQQ
 2981- 3006 (38.12/11.80)	M...QPAQQ..Q.H.Q.PP.AYQQGNNQMQMNMHQ
 3007- 3026 (29.75/ 7.13)	....QQQQQ..Q.Q........QQQIRQQATAQPQ
 3030- 3047 (30.76/ 7.69)	Q...GGMNP..Q.A........QQQAY..P.GYSQ
 3303- 3326 (28.33/ 6.34)	S...QHQQP.aQ.NmN.QP.AQAQSQQQN....PQ
 3331- 3355 (28.61/ 6.50)	P...GQYAR..P.T.Q.EG.AYSQQGYNQPAA.AQ
 3357- 3386 (29.47/ 6.98)	YqrpEQQQPasQ.N.Q.WP.AQTQQANQMRQQ.PA
 3460- 3485 (36.05/10.65)	H...HQQQP..N.P.QtTP.QYPQPPQQQPSQQP.
 3566- 3592 (30.13/ 7.34)	Q...PQQQS..RmS.Q.PG.MGQPGMGQSTMGQPG
 3790- 3811 (30.85/ 7.75)	.....QQQP..Q...Q.PGqQQQQHGYMGQ..YPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.34|      17|      19|    2401|    2417|       4
---------------------------------------------------------------------------
 2390- 2406 (19.92/ 7.95)	AKKTDEESKTD....EEKKKD
 2407- 2427 (18.91/ 7.16)	EKEGEKSAEEAdadkDKDKET
 2428- 2447 (18.50/ 6.84)	DKEKEKTAEGA.tksDEVVAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      15|      15|     845|     859|       5
---------------------------------------------------------------------------
  845-  859 (27.39/12.58)	EPEKE..KTPEVVEEPV
  861-  877 (23.12/ 9.41)	EPEKAsmETPAPMETSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.94|      15|      21|    2801|    2819|       6
---------------------------------------------------------------------------
 3403- 3417 (24.99/ 6.25)	Q..QQQYQQAQAQTQQA
 3541- 3557 (19.95/ 7.92)	QqnAYGMQQNQMHQQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     608.85|      63|      68|    3151|    3213|       7
---------------------------------------------------------------------------
 2617- 2665 (60.51/19.39)	NP....AVPGStAPVAQT.......QQL.PGMSTDNM...................PglmGQHQ..QSQ.QGM...NQPMH..QQ........PPP....................................................
 3068- 3130 (60.21/19.25)	.P.FG.AQPEM.QQPGGA.......KMLmPTKPNEAH...................A...QQYQhtQNQM.A........L..SQkekekqyfQAKNAQ.............................A....GQ.....AT..GQ.N
 3131- 3158 (32.23/ 6.09)	.PRFGdATAG..NASGFG.......R.......................................................................................................nmsfGQ.....QQ..QQPN
 3159- 3229 (113.25/44.19)	APDFP.ATAQV.PPTNPT.......RLL.PGPTVNPN...................P...MQVQ..QTAMQNY.QQQQPVL..GQ........PAPMQP.............................G.gptGQqqpaaQQ..QQYN
 3237- 3296 (62.30/20.23)	TPDMS.....V.RPTQPGsmgqmqnRMG.PG....................................SGTQGYvQPGQNVS.gGY........PQAQQP.............................GqtayPQ.....QQ..TNYA
 3422- 3497 (63.48/20.78)	NP........M.APQN...........A.SYRGGFP..........................AQ..QQQ.QGY..EQQPA...QA........PVHQNPpihhqqqpnpqttpqypqppqqqpsqqpvH....QQ.....QQpqQQQN
 3608- 3632 (39.97/ 9.73)	...MS.........................G.MGQPV...................P...QQVQ..Q...T...QPI....................QP.............................A....Q.......Q..QQ..
 3633- 3687 (84.53/30.68)	.PQ...AQRGM.NPMGGA.......QLP.PYSMG...........................QQQ..QQATQ...QQQQEHYrrMQ........EAQQLQ.............................L....QQ.....QQ..QQQR
 3688- 3743 (40.68/10.06)	T.......AQA.QA.......................aqaaqaqaqaqaqaqaqaqA...QQAQ..QNAMG...IPQQP....AA........QQQMQG.............................G...yGN.....QM..QQ..
 3744- 3782 (51.71/15.25)	...F.........PSLQH.......R.A.QGP...............................Q..AQGMGAM.GAQQQV...QQ........PAANQY.............................Y...hPQ.....QQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      85.65|      15|      16|    2803|    2817|       8
---------------------------------------------------------------------------
 2803- 2817 (27.66/14.54)	RRQQEEMR...RREAEER
 2819- 2836 (20.50/ 8.23)	RREAEEQRirlQREAEER
 2874- 2887 (18.73/ 6.66)	RREKEEAM...RLEQER.
 2913- 2926 (18.76/ 6.69)	AR.LEQQH...RLNQQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.18|      12|      16|     623|     635|      10
---------------------------------------------------------------------------
  623-  635 (21.53/14.83)	DFSnPTPPEAPPP
  640-  651 (22.65/10.28)	EFV.SSPSESPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.87|      16|      16|    2467|    2482|      11
---------------------------------------------------------------------------
 2467- 2482 (27.87/15.73)	AKEGDTSTPKPAPVAR
 2486- 2501 (28.00/15.84)	ATRGRGGGRKRNSGAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      14|      16|     271|     284|      12
---------------------------------------------------------------------------
  271-  284 (24.98/18.08)	FLNDLTEAFNIFFI
  289-  302 (25.82/19.00)	FKDDILQKFMAYFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.05|      15|      16|     899|     914|      13
---------------------------------------------------------------------------
  899-  914 (23.21/19.11)	INAPMVMPQKeTTSER
  916-  930 (27.84/17.71)	ISDGIVVPPM.TPEER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.85|      20|      21|    2755|    2775|      14
---------------------------------------------------------------------------
 2755- 2775 (28.56/21.38)	QEERKRAiAESNRLIEAQRLA
 2778- 2797 (33.29/19.99)	QEEQRRR.EEQLRIQEEARQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.77|      14|      18|    2133|    2150|      16
---------------------------------------------------------------------------
 2133- 2150 (18.48/24.15)	YKEILKPTHVEpwglLIF
 2154- 2167 (24.29/14.49)	YHGIINQAREK....LVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.01|      13|      16|    2534|    2546|      17
---------------------------------------------------------------------------
 2534- 2546 (24.29/15.16)	SGGSGGNYHAAMR
 2553- 2565 (21.72/12.70)	SNGSSDETKVNIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.56|      10|      21|    3501|    3510|      23
---------------------------------------------------------------------------
 3501- 3510 (18.70/11.24)	GYAGSNASSN
 3524- 3533 (18.87/11.41)	GYTSTNTSSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26603 with Med12 domain of Kingdom Metazoa
Unable to open file!