<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26595

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAVLGGTTPVGSTPGYRAPVPPDPQPTSAQARNPPSTVATTQASTTPSSQSTVPAGTVSASAAVAAAVANFPSPDTALRVGGQTTPGSQSSGQSSAPNVPFPNGGPQQGSVPMNGGGGPAMGQPPPQMGAPNMGMGGPPGGYGGYGMMNGPPGGGPMGSNPYNQQMKKEMEQNRPWDPQGHMYQQPQWGGMPPQQGHGYPNRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMGPPGPDRNMPGNRPGGGPGGPQRPGMPVNQAMMSVEDQNVYSMKLRNMRGSCESLRTRARQCRQEGNHEAAHKLEVMLSVLEGKRVVSLEYLNHLETWIARKQDFLNINQMAQNPNHMGMNDPVMNGDHGMMGNGQVHNPYGGHPGYNHGQYMGGPPPHMQQQMHQSQQMWHQQQQQQRMMQPQDHMMMGGGGPMHGMYRGDMGHDQMTSPVNNHRHAPYQNPAMRNNMRQMPNGPGQIGRDRNSMSGSMSGPSSGAPSMNPMGTPNQKMGTPGSIGGLSGLDDFTYDDFLPNPIDALQPTLHVGNPSNSMNSGQPVQRASLTETARKELQALEARFEIDPNHQRHDANHILVSCKLRNQPYPPLRLVVPTTYPAGSVTVDRAVIDLDAYLYDDLQNVVNERLSRPGLSSLTDYLNAWEEQVNQYLQQNQSNMDPSFGVSNDFFYENLNL
Length776
PositionTail
OrganismCaenorhabditis remanei (Caenorhabditis vulgaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.05
Grand average of hydropathy-0.839
Instability index58.13
Isoelectric point6.60
Molecular weight84158.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
nuclear hormone receptor binding	GO:0035257	IEA:EnsemblMetazoa
transcription coactivator activity	GO:0003713	IEA:EnsemblMetazoa

GO - Biological Process
determination of adult lifespan	GO:0008340	IEA:EnsemblMetazoa
embryo development ending in birth or egg hatching	GO:0009792	IEA:EnsemblMetazoa
locomotion	GO:0040011	IEA:EnsemblMetazoa
nematode larval development	GO:0002119	IEA:EnsemblMetazoa
regulation of fatty acid metabolic process	GO:0019217	IEA:EnsemblMetazoa
regulation of multicellular organism growth	GO:0040014	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
sequestering of triglyceride	GO:0030730	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     182.11|      34|      34|     177|     210|       1
---------------------------------------------------------------------------
  186-  219 (64.58/16.79)	SA.......PNVPFPNGGPQQGSVP...MNG..GGGP....AMGQPPPQM
  220-  260 (39.68/ 7.38)	GA.......PNMGM..GGPPGGYGGygmMNGppGGGPmgsnPYNQQMKKE
  494-  529 (37.44/ 6.54)	QQmwhqqqqQQRMM...QPQDH.M....MMG..GGGP....MHGMYRGDM
  582-  606 (40.40/ 7.66)	GA.......PSMN.PMGTPNQ...K...M......GT....PGS.IGGLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     312.66|      54|     153|     282|     335|       2
---------------------------------------------------------------------------
  282-  335 (108.35/40.67)	MPPQQG.HGYPN.................RP.MNGQQTTPTGTSSVLESLINQPQQYPGH....HNQ.M..GPPGP.....DRN.M
  338-  384 (66.77/22.09)	NRPGGG.PGGPQ.................RPgMPVNQA........MMSVEDQNVYSMKL....RNM.R..GSCES.....LRT.R
  387-  449 (55.40/17.01)	QCRQEGnHEAAHklevmlsvlegkrvvslEY.LNHLETWIARKQDFLN..INQMAQNPNH........M..GMNDP..........
  450-  490 (38.64/ 9.52)	..............................V.MNGDHGM.MGNGQVH.......NPYGGHpgynHGQyM..GGPPP...hmQQQ.M
  530-  572 (43.51/11.70)	.....G.HDQMT.................SP.VNNHRHA..............PYQNPAM....RNN.MrqMPNGPgqigrDRNsM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.41|      32|      76|      71|     103|       4
---------------------------------------------------------------------------
   71-  103 (55.14/31.40)	SKSAAVPSVLQPSQFHSPPCT.TAVLGGTTPvGS
  122-  148 (30.31/11.66)	ARNP..PSTVATTQASTTPSSqSTVPAGT.....
  150-  179 (49.96/24.37)	SASAAVAAAV..ANFPSPDTA.LRVGGQTTP.GS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26595 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DALQPTLHVGNPSNSMNSGQPVQRASLTETARKELQALEARFEIDP
2) MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGD
3) PSVLQPSQFHSPPCTTAVLGGTTPVGSTPGYRAPVPPDPQPTSAQARNPPSTVATTQASTTPSSQSTVPAGTVSASAAVAAAVANFPSPDTALRVGGQTTPGSQSSGQSSAPNVPFPNGGPQQGSVPMNGGGGPAMGQPPPQMGAPNMGMGGPPGGYGGYGMMNGPPGGGPMGSNPYNQQMKKEMEQNRPWDPQGHMYQQPQWGGMPPQQGHGYPNRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMGPPGPDRNMPGNRPGGGPGGPQRPGMPVNQAMMSVEDQNVYSMKLRNMRGSCESLRTRARQCRQEGNHEAAHKLEVMLS
4) QDFLNINQMAQNPNHMGMNDPVMNGDHGMMGNGQVHNPYGGHPGYNHGQYMGGPPPHMQQQMHQSQQMWHQQQQQQRMMQPQDHMMMGGGGPMHGMYRGDMGHDQMTSPVNNHRHAPYQNPAMRNNMRQMPNGPGQIGRDRNSMSGSMSGPSSGAPSMNPMGTPNQKMGTPGSIGGL
622
1
77
429
667
38
405
605










Molecular Recognition Features






MoRF SequenceStartStop




1) KFREHV
10
15