<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26590

Description CRE-RGR-1 protein
SequenceMNFNSIRAKLSSQLRAALAADSPANAVPVSPDPNGSGLSLDESSGISDREALSSQEQTMQYSEVDAKSVHSSDSEDEPVQNPLPEVPANCGPRTVQLSVLLDFAIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQRAVCSRLNQLIETRLSRLSNGIPPNIREIHIKNGLATLLVPGEFEIKITLLGETEMVKWTLLNIKILVEDYELGMGLPLVHPLQLNQIHGVLQSRMNVAANPIKEAFFFLHSFCVSLQLDVLYCQTSRMAAGRLRENIVIEKYDPKERVLIVGYWVKRSKNKKLTVGQLKVDAQYRVQVYEDKDDKLGGLKVRHFPHAPQLGTIDCNAGMLSMDRLLSETFDVRCKERLMRLRRLLEAAEPLLEVKMTGLSVPSLSLTLLPDTTSTEEMLTVSVNSFCGKVICNVNMLSSENEDVLAFARALYSSRCSDTTIRSYLAKLRVSIVIERYRRSVKALPIYEVLETELFPFVKEVLRETPAQRLVLRYLRQEMYYLIVSFQPDEKEVVSTKLLLLEVDEDRAQFIPLDNDRDVYDATVAGAVAQGTLKFADLHKISLQKECSREQRLAFAIATIEDRVTYMYVAAELDRKGVGVDLRKDDVHVPGGLALHITELVYFECQNSNRPFLASQALYHLMLHSSFNAVSVVASVLTTEIVTRFNSKCASRIFHWFAMYLTVSHIVEMETTWVQEINQINQMTPEKLTEGIIHRLMRYLYMYKVVFQFSQAYNRYFKSFCSIEAYTFHKLVVSYGENRDMLMVLAFNVKSQTPGSSEDYFLMNFGQTMPHKQFNATEIDWHQKPRWNPHVMMAQLLRDQLKETSDLVYIMHYLCETIRPLAALGNFVRIRFQSLKSLSQLIGPEVHFPFRLKYHLTPIDQFTLRLMHGNVILEIKMLREMRIAVRDVSRYQPRCAGLFQLFSNIDRLVTIQIVFLIGLFHFSETTQLLAEELPIPQSDCEHAAGPKMWTKDQFMETIDDRHEEPDARMAVTTQPVLMTHDTIIKACDFQEIDGRVTCPLDEYLNSIFYLQRALLTLERMSPRANPSQNSNNNLFSGYVTVVDSRPEHIRFRALQLNGDGLNATSMVHYKIYLCPIAMTLKIAIDYDEGTNSEATQENLDTLATYFEKIVFRCGDEYALQSYVLMTRVTSYGATKSIANLMNAQMGITPTSKCCMQLSLTYNNTSTKKLAPATKVDQQLNNIIFNVIISQSRTSESFSILRFIYRIKENMVTTPSVEIKQMADDVNAETKSSGQCAIWALVSLVSDRFRSGVWNPSNRDEPIISSVAPTANYANPGSVAAPGSIAPGSVAPGSVAPASQQPGSIMQPGSMMGPQSVNAHQYGMHRQMGGPPSMQMNPSSVGPQPGSVGMPGSVGGPGSMMNPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGHPNYPQWNPPPSGQYHPHHMPYPPQ
Length1546
PositionTail
OrganismCaenorhabditis remanei (Caenorhabditis vulgaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.179
Instability index42.08
Isoelectric point6.69
Molecular weight174125.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26590
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     241.38|      23|      25|    1472|    1494|       1
---------------------------------------------------------------------------
 1384- 1408 (19.42/ 6.49)	....PSNRDEPiiSSVAPTANY.ANPGS.vA
 1409- 1428 (35.02/18.48)	A...PGSIA.P..GSV.APGS..VAPAS..Q
 1429- 1445 (33.80/17.55)	Q.........P..GSIMQPGSM.MGPQS..V
 1448- 1469 (35.20/18.62)	H.....QYGMH..RQMGGPPSMqMNPSS..V
 1472- 1494 (52.95/32.27)	Q...PGSVGMP..GSVGGPGSM.MNPGS..H
 1497- 1522 (37.17/20.14)	HmmnPGSVG.P..GSVGGPGS..VNPGSvgH
 1524- 1544 (27.82/12.95)	N..yPQWNPPP..SGQYHPHHM.PYP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     192.70|      40|     117|    1102|    1141|       2
---------------------------------------------------------------------------
 1031- 1053 (21.06/ 9.04)	................FSNIDRLVTIQI.VF.LIGLFHFSE
 1055- 1090 (53.92/36.24)	TQ..LLAEELPIPQSDCEHAAGPKMWTKDQF.METI..DDR
 1102- 1141 (71.41/50.72)	TQPVLMTHDTIIKACDFQEIDGRVTCPLDEY.LNSIFYLQR
 1224- 1256 (46.30/29.94)	TQENL...DTL..ATYFEKIVFR..CG.DEYaLQSYVLMTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.12|      33|      42|     809|     846|       3
---------------------------------------------------------------------------
  822-  859 (53.65/46.19)	IHRLMRYLYMYKVVFQFSQAYNRYFksfcsIEAYTFHK
  866-  901 (53.47/33.86)	ENRDMLMVLAFNVKSQTPGSSEDYF..lmnFGQTMPHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.58|      64|      79|     379|     455|       4
---------------------------------------------------------------------------
  379-  450 (90.63/88.65)	EKYDP..KERVLIVGYWVKRSK...NKKLTvGqLKVDAqYRVQVYED..KDDKLGGLKVRHFPhapqlGTIDCNAGMLS
  457-  527 (90.96/53.45)	ETFDVrcKERLMRLRRLLEAAEpllEVKMT.G.LSVPS.LSLTLLPDttSTEEMLTVSVNSFC.....GKVICNVNMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.03|      62|     439|     278|     376|       5
---------------------------------------------------------------------------
  193-  264 (95.98/87.74)	DLELAR.LPEYHiaP....AIDVLVLGTYNRMPSKIKEAFIppakitprEQRAVCSRLN.QLIETRLSRLSNG.IPPNI
  308-  376 (93.05/65.74)	DYELGMgLPLVH..PlqlnQIHGVLQSRMNVAANPIKEAFF........FLHSFCVSLQlDVLYCQTSRMAAGrLRENI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.99|      26|      43|     727|     753|       6
---------------------------------------------------------------------------
  727-  753 (44.19/34.95)	TELV.YFECQNSNRPFlASQALYHLMLH
  768-  794 (44.80/30.44)	TEIVtRFNSKCASRIF.HWFAMYLTVSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.68|      34|      43|     634|     669|       7
---------------------------------------------------------------------------
  634-  669 (49.08/48.97)	EDRAQF.IPLDNDRDVYdATVAGAVAQGTLKfADLHK
  679-  713 (52.60/40.06)	EQRLAFaIATIEDRVTY.MYVAAELDRKGVG.VDLRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26590 with Med14 domain of Kingdom Metazoa
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