<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26586

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLSSKEGDKDALKNKLKNAKRPEFINGGSLEDCLSNVYSLLELPGIKWKCFRTKPNAPRGVPLTSDLVLKAYSRCVLDGILCTWRRKPSAPTDNDELLPATHFFSNDSPKELWVFWYDDEPIDLPKLCEGLESDEELSSANQMNIVSYEVRTLIFKALHVVLERDLTKDGFVRFGRWFTVPLLARDNYLHFMYPTHSPAIRFNFFVHGTHTVCASVQAQRQPTLISLAKRHFDCKTAKRFPVVVGPWSMRGYLIQDQMTLLADPKIQEAAEKEWNQWKEYLQLEEKEPENVVDERQKSPDSEPTTAPPPAPRVLLASSSDEEQPKSDGNDDVANDNIPQKFRWMYEPDYRQEKPKEETPEEKEKRMQAREVRRIRRKNREERLKELERQRAETTNPEDYDSDVVTDVEVEVKEESVSSEVPRMILIEIDNVRLLYPSKFICITVEEDRQVLESMGLKTHPPPQELQVQGRRPRNKNVVSASNPILSTMAVYQYCERQRMIDRERLNKENAHEDQYHDRHLRAVFAERKAIIDKKEKVPNFPPVPSPPPFELYKHKETYLSWKSARPASLMSYRPRVRSHMPTYDPNNDEETFNKEWECYQALATARMKCRLGTKFDFHSYHKKRLLKTPKERRKTKKMKIPKISRKKFESEMAYNNFLKKKKTRLKQIGEKRRSKRSRPSGSIRAESEDEAYQMDKLSQQDWANLEDDHPKVIPEIEVEKEELFNEIKLPKAPNDDTYKPKPFFPVSLLTTVSSRSELIPLAGDEEMSEERFNAVFKDPNNRWKPGMSKGEKIDNATYVFDPSNRMPVSPRNYHLGDYLKKPPYDRNIDAPRNNKYFKGDICRKGLRGFEAICAEKEEIESVKKEKWLKKHRRKESKRQIKTARDCHLEMEKQLVKRSLKRSLKKLRISAKKDSLSDPIIQEEEVDPLLLNRVDVKALDKSVKLMENELDQLNMNTFCINREKAGPHGVPSSSGYIPADYTLSPHCSFEEESDSEIDEQRTGLGEGTSDQYEEGESVDMVESDREQITDHSLDFANIGHIRTVGEHIGPDGLLSPPASNEMPKGGPLSVGPPSIESQGLNQIYPTPPSVQMLQENAAQGHSPVMMHGKLRYTANAGDDDIERVDVPGGCGKIVEIPDDDSETKHMKKLNKLVNQPKLTNFLVSSCHNPILKGRKIRYDTPITDKFKLQSETEKVTAELVYEPMVKRNFECPPPRTFGVLAQKKRSGKRAPLPSSLPSTFSALNPGFANPMGPPIFQSPTLPPHHIQSPFSMGPMGHHPMGPPNYPATPGPFPPTTPTYPGMTPRPGSNFGPGFGYPNQQMMPPAYSNQIGSMGQIGQMGQMGQMGQMGPMGPMGTMGVQRQFSNPQMYQHQMQMRMQQMRQMSGQGGPPGYGGPGVPPFQSPVTPAPGGFGMSTGPSSVQRLNNFVNQSQFGPSSGQSYGSIPPMIPQSPNFNQPFPGMGNAMMSPMQQHQFHHQQMMQQHQQQHQQQHQLQMQRNQAQNQNPQTNNQQAVQPFQPSAQFLQQQQYEQVNAAFNQLSDREKQKFNRRQIQLLHGIMPTSLQPASIKALRNPPDANIPFKKPDPIYRHPDLNIPRGDSLTIAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDLGMYITPHMVLSSRERGQTNMREYTVGTWSGFHVNSATNCTCGFSAIRHRYLSCCSGLFEEDADEATTSEHAMAPVIPPLNYPKRTGRDMTWFDSKSVHDMALLNQIRQMAFSNSIGKAVSQMASGAEHARNIAIAMDVGTDVTVPSEYTLSHVDTLELLMLGMSALGPMQKSGIGNQIASQNKFLSYFHPWGFQTANEITELEASEWVDLLGIVTPTLEVSMKHARHLPAEAPSTVEGPMTWKQIVTKAIRGKPLSDDDEDYSLTEPVPAVMRALTKEAIRAAPNIEQYSDQASLGPIDQPKDVMYITIIPDDPTIYEKAVEFMDNVTATYERMRLGRHIPFPVSTGTATKFRKVLEEQQNQFTFSEKTPQPENEEKREKDRKDYDDYFGREPVETDLDFWIRRAKRKFESYEDLRKTEDTAIPPPDPFDKEMSKNIVYRHRMSGFPFREDSYYEREGILRVGTPLERSRLQHTVTNTPEFENMTRHLNDKNGFVTKLRLYLQQMEDLVHHALIENAEAFERTGYRYQLAVEGRLKRRQHRKGINEEWLRYESAKLLEDEVTIPVQPEEADLCTGVEVGNEGSVPWVNDELQEKKELKQKENEQYPPEGHQAPSPVPAGMIHIPETLSKQERMVQPSLNDIFADPSTVAPMNAQNISWKKRDTHVPNPFPSSNQPPVAFEATGSLDTDAISTLPHVIVLYVVNPFSYGPEGHSAIHMRIAILAFIRAFNSIIGRLPFQKRPQLQLEIIGLESLDDVAKSIPDYFNDPKVPFDILHDNQIKFERTAEAEQAEIVRSLSIAVYTHPRVFTPDVYKSVSARCMTAFGPGSQIINTINNIEKINQDSFFRMSKRSKMALETIDGFRHPGMMAPQQVEKKNYIAYRVPSNILCLAPPPPVYQMDEDGKPVLNQLDEQTLFISYCLVGADFLVATATDAQGKLIDNCVANIKPRRQRNQVYRYRNKTQILDGMGKLWSFILGVMSSDIKNWRLVVGRLGRIGHGEFRAWTHLLNKTSLLRYSGSLKDICSACRSMPTAVGTPAILSACLITLEPEPSIRIMPDFQDQSATTKKSYIFQTPGDLSCTHILTFPVGTEINLEVQDQTADTKADENWDFNDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQSGGTSMFFSEDSSSIEIQNQPLASGYYISTAPAPELPSWFWATCPSAKRHSPVHLKSSLHINISEVKNDDIAMESAKEKDKDKEKEEKDVHPLESRQTEEVLRHVLESYNALSWLNLNRQTGERYSCLPIHIQHLLRLYHSVARLLV
Length2923
PositionMiddle
OrganismCaenorhabditis remanei (Caenorhabditis vulgaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.687
Instability index53.81
Isoelectric point6.44
Molecular weight332437.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003861
	 href='https://www.uniprot.org/unirule/RU364134' style='color:#FF0000;'>RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP26586
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     197.00|      28|      28|    1235|    1262|       1
---------------------------------------------------------------------------
 1235- 1261 (50.29/23.43)	..................LPSTFSALNPGFAN..P...MGPPIFQS.PTLP
 1262- 1282 (27.76/ 9.26)	P...............hhIQSPFS.MGPMGHH..P...MGPP.........
 1283- 1299 (28.77/ 9.89)	.....................NYPA.TPG.....P...F.PP..TT.PTYP
 1300- 1328 (34.11/13.25)	G................mTPRPGSNFGPGFGY..PnqqMMPPAYSN.Q...
 1369- 1405 (30.56/11.02)	QhqmqmrmqqmrqmsgqgGP.......PGYGG..P...GVPP.FQS.PVTP
 1407- 1443 (25.52/ 7.85)	P..........ggfgmstGPSSVQRLN.NFVNqsQ...FGPSSGQSyGSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.75|      19|      28|    1043|    1061|       2
---------------------------------------------------------------------------
  975-  990 (21.19/ 6.68)	...YIPADYTLSPHCSFEE
 1003- 1019 (25.09/ 9.39)	LGE..GTSDQYEEGESVDM
 1043- 1061 (36.47/17.30)	VGEHIGPDGLLSPPASNEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.31|      12|      19|    1476|    1487|       3
---------------------------------------------------------------------------
 1476- 1487 (24.40/14.70)	QMMQQHQQ.....QHQQ
 1497- 1508 (20.61/10.99)	QAQNQNPQ.....TNNQ
 1509- 1525 (16.30/ 6.78)	QAVQPFQPsaqflQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.93|      35|      36|     620|     655|       4
---------------------------------------------------------------------------
  620-  644 (33.52/17.20)	.........................YHKKR..LLKTPKERRKT.KKMKIPKIS
  645-  682 (41.90/29.07)	RKKFESEmAYN.............nFLKKKktRLKQIGEKRRS.KRSR.PSGS
  684-  731 (33.50/17.49)	RAESEDE.AYQmdklsqqdwanledDHPKV..IPEIEVEKEELfNEIKLPK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.02|      11|      21|     773|     785|       5
---------------------------------------------------------------------------
  773-  785 (17.34/17.56)	NA..VFkDPNNRWkP
  795-  807 (19.68/ 9.03)	NAtyVF.DPSNRM.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.32|      30|     746|    1199|    1234|       6
---------------------------------------------------------------------------
 1199- 1234 (46.79/49.83)	VYEPMVKrnFECPPPRTFgvlaQKKRSGKRAPLPSS
 1950- 1979 (54.54/38.21)	IYEKAVE..FMDNVTATY....ERMRLGRHIPFPVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.89|      49|    1808|    1066|    1120|       7
---------------------------------------------------------------------------
 1066- 1117 (83.19/59.00)	PLSVGPPSIES.....QGLNQIYPTPPSVQMLqenAAQGHSPVMMHGKLRYTANAGD
 1130- 1183 (78.71/41.48)	GKIVEIPDDDSetkhmKKLNKLVNQPKLTNFL...VSSCHNPILKGRKIRYDTPITD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.43|      48|    1808|     360|     409|       8
---------------------------------------------------------------------------
  271-  308 (45.88/28.63)	.............EKEWN.QWKEYLQLEEKEPENVVD..ERQKSpdsePTTAPP
  348-  397 (76.23/60.66)	DYRQEKPKEETPEEKEKRMQAREVRRIRRKNREERLKelERQRA....ETTNPE
  398-  424 (28.32/13.27)	DYDSDVVTDVEVEVKEESVSSEVPRMI...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.51|      14|      30|     489|     504|       9
---------------------------------------------------------------------------
  489-  504 (22.35/23.51)	AVyqYCERQRMID.RER
  522-  536 (19.16/10.86)	AV..FAERKAIIDkKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.85|      14|    1808|     537|     550|      10
---------------------------------------------------------------------------
  537-  550 (32.38/15.24)	VPN.FPPVPSPP.PFE
 2299- 2314 (21.47/ 7.09)	VPNpFPSSNQPPvAFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.78|      79|    1808|      32|     126|      11
---------------------------------------------------------------------------
   42-  120 (151.76/96.24)	ELPGIKWKCFRTKP..NAPRGVPLT.....SDLVLKAYSRCVLDGI.LCTWRRKPSAPTDNDEL.LP.....ATHFFSNDSPKELWVFWYDDE
 1575- 1623 (43.26/12.71)	NIPFKKPDPIYRHPdlNIPRGDSLTiaivlSDTLLDLHFDSVFDACpIC............................................
 2177- 2224 (45.75/16.83)	............................................GI.NEEWLRYESAKLLEDEVtIPvqpeeADLCTGVEVGNEGSVPWVNDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.17|      29|     107|    1990|    2019|      13
---------------------------------------------------------------------------
 1990- 2019 (46.72/28.34)	LEEQQNQFTFSeKTPQPENEEKREKDRKDY
 2100- 2128 (51.46/27.46)	LERSRLQHTVT.NTPEFENMTRHLNDKNGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.46|      10|      36|    1337|    1346|      14
---------------------------------------------------------------------------
 1337- 1346 (22.09/12.04)	QMGQMGQM.GQ
 1375- 1385 (17.37/ 7.95)	RMQQMRQMsGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.75|      24|     107|    2359|    2382|      15
---------------------------------------------------------------------------
 2359- 2382 (42.58/33.41)	IRAFNSI..IGRLPF...QKRPQLQLEII
 2464- 2492 (31.17/21.80)	INTINNIekINQDSFfrmSKRSKMALETI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26586 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSFEEESDSEIDEQRTGLGEGTSDQYEEGESVDMVESDREQITDHSLDFA
2) EKEPENVVDERQKSPDSEPTTAPPPAPRVLLASSSDEEQPKSDGNDDVANDNIPQKF
3) LQPASIKALRNPPDANIPFKKPDPIYRHPDL
4) MGPPIFQSPTLPPHHIQSPFSMGPMGHHPMGPPNYPATPGPFPPTTPTYPGMTPRPGSNFGPGFGYPNQQMMPPAYSNQIGSMGQIGQMGQMGQMGQMGPMGPMGTMGVQRQFSNPQMYQHQMQMRMQQMRQMSGQGGPPGYGGPGVPPFQSPVTPAPGGFGMSTGPSSVQRLNNFVNQSQFGPSSGQSYGSIPPMIPQSPNFNQPFPGMGNAMMSPMQQHQFHHQQMMQQHQQQHQQQHQLQMQRNQAQNQNPQTNNQQAVQPFQPSAQFL
5) PPPRTFGVLAQKKRSGKRAPLPSSLPSTFSALN
6) QQNQFTFSEKTPQPENEEKREKDRKDYDDY
7) SVPWVNDELQEKKELKQKENEQYPPEGHQAPSPVPAGMIHIPETLSK
8) VGEHIGPDGLLSPPASNEMPKGGPLSVGPPSIESQGLNQIYPTPPSVQMLQENAAQGHSPVMMHGKLRYTANAGD
9) VLESMGLKTHPPPQELQVQGRRPRNKNVVS
10) WMYEPDYRQEKPKEETPEEKEKRMQAREVRRIRRKNREERLKELERQRAETTNPEDYDSDVVTDVEVEVK
986
285
1560
1250
1211
1993
2217
1043
450
343
1035
341
1590
1521
1243
2022
2263
1117
479
412










Molecular Recognition Features






MoRF SequenceStartStop




1) YKHKETYL
552
559