<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26579

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTILEGKNNKDEHAHNHKQNVNNEPYYHQSKNQKHQNNHQQQQAFISTSPASSSSSSSNHQLTKKFKSECSAQRHIQFDQETLNQIDRVELQRLWGPHLVPLQFVIQRTIAQVFNELQILSQISPNLEDYDRKKRVIDFVVHSRRQLIKLLVLVKWSSNSVPVHKIMSIVAFLQRQNSQFERNVNILKASKESFHSARMRNYDLATALQVLTNGYPTLPGRLIDQFDSKPKLSDSEVIKIMHDLNELIRYRLASCEVIPKEFRSYRIYDGRVVFKISRMFECSLTLGGGELDSQWYLLHVEFLFRVTGPRGKDFMSIPQGPVKSQIIECGNRTMAPNTLPTEADPDPKPPERPIMKLFAYLRDLCLNYQLEALHYQASQLGRSAWATHTRLLISPDRSNLTIVYWLHARPVSIPVTRPGQQPPRNPPQPTPQGTLTVRRHIERHSPSRTRVLDFLNGYPLKDKLPSDGQDGDFGASHTERLQVVWRPSEVTSRGGPVTREVLGGLKIREGDEVDFLKTDSGQLELELKILYFETGLFRLDTTRPTSGRFFNTRRTVLCLSTADTMEDTSSSERFAKSIEVVLHARHAIEVLIDQFSGRFRLQSITNPIRLDEGDNDSHIAGSWLVLVVIIRQAKQSAINHANPSGLRDVLVRLNSDILLDQIEFKARLLGIQTTRNLPIQLQLLSMPSYLSSPSTIPQHIFQLTLYCRLSNFPHHYLLIMVTENGIRCALIIVNQKRDDQPSNHGGSSMSWNVNSVSAVEVPTFSDDLDEDGGVLDQFTLSRTQLQYVYHYCLVQVTLSQLKAPLRQNQISYEQQLPVTTEIIKKTYQEHRNQRPKLTGKPPPSSIKLPEFHQAHEVTGLLLIPLQGFLKPSFFHSHHLLTQKDIFDGQKLALKVLLQPESHFGVQLELRFKFNPDKLKAEELEKIIKSKETNLNSKIVSNYLMRQAKSQSPVTPNPRNFGQPPKDDDDDDDDEDEEPLSRRIQPTRPKPASPAVTNTAEEPRKECPNLEEDPDAEFVDSDSWSIDAQSNQFIMRFQNFNQQIDQIYPLSIQKFINLIHSDADPLP
Length1067
PositionTail
OrganismPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.07
Grand average of hydropathy-0.534
Instability index50.48
Isoelectric point8.14
Molecular weight122137.18
Publications
PubMed=21536894

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26579
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.35|      35|      47|     438|     484|       1
---------------------------------------------------------------------------
  438-  475 (55.95/59.68)	VRRHIE...RHSPSrTRvlDFLNGYPLKDKLPSDGQDGDFG
  485-  522 (57.40/31.30)	VWRPSEvtsRGGPV.TR..EVLGGLKIREGDEVDFLKTDSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.92|      61|     312|     565|     644|       3
---------------------------------------------------------------------------
  577-  644 (91.67/106.69)	KSIEVVLhARHAIEVLIDQFSGRFRLQSITN....PIRLDEGDNDSHIAGSWLvlvviIRQAK.QSAINhANP
  645-  683 (36.73/12.20)	SGLRDVL.VRLNSDILLDQIEFKARLLGIQTtrnlPIQLQ.................................
  928-  958 (32.51/13.66)	....................................IKSKETNLNSKIVSNYL.....MRQAKsQSPVT.PNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     389.28|     130|     684|     104|     241|       5
---------------------------------------------------------------------------
  104-  241 (210.21/149.45)	QFVIQRTIAQ.VFNE..LQI.LSQI.SP...NLEDYDRKKRVIDFVVHS.....RRQLIKLLVLVKWSSNSVP.VHKIMSIVAFLQRQNSQFernvniLKASkeSFHSARMRN....YDLAT.ALQVLTNGYPTLPGRLIDQFDSKP.KLSDSEVIKI
  778-  927 (179.07/111.90)	QFTLSRTQLQyVYHYclVQVtLSQLkAPlrqNQISYEQQLPVTTEIIKKtyqehRNQRPKLTGKPPPSSIKLPeFHQAHEVTGLLLIPLQGF......LKPS..FFHSHHLLTqkdiFDGQKlALKVLLQPESHFGVQLELRFKFNPdKLKAEELEKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26579 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPVTRPGQQPPRNPPQPTPQGTLTVRRHIE
2) MTTILEGKNNKDEHAHNHKQNVNNEPYYHQSKNQKHQNNHQQQQAFISTSPASSSSSSSNHQLTKKF
3) RQAKSQSPVTPNPRNFGQPPKDDDDDDDDEDEEPLSRRIQPTRPKPASPAVTNTAEEPRKECPNLEEDPDAEFVDSDSWS
414
1
946
443
67
1025










Molecular Recognition Features






MoRF SequenceStartStop




1) PLSRRIQ
979
985