<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26570

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMVKKHTSIAIAPPAPRLLANDLPTDRDLTAAQKDTLWDFTDGGAKIWKEPQDEPSKLTSNLKRLWIERGDFSQLTIESIEKQKAKPVSELEVPKSNEDDAAENQASKRSETITVDELWEMRMQMAHQLLVMSGELSTGLDLLNTLLAPLAPDAVDTTSLPLPPGGIAPMTHSLDHLSPQPEPITLINSSVSLMRKRKAAQNASCLLKRAASELGREAKRSQNEWDTLLKLREAGWNMRPKGAKPGVDMSLMGRGAERAAKEIGIAYATTEAAEALRASSFASLEPLNLDDHESTQISLKLPPRPRRRLAITLALPNQPIERFSPWERHNLEEIDILPFGEDLELARAEVLEEEIFGEISKEAQSSATYRTSTSDRSVVVKGFWEDAEISFEMLESHEETHTTTEMSSKCRLISALIRLLMVSIYRSRRSCAIGIMTANTQPSQPKILEPVLGLTVFFIYTYNLHNLFSQAVSDLKPTKLEVEAELDPILESASGMVNLICGRSNTSPQKLEVGGIAALRIMGRRLVTFTITCPVVISFWLKDEPMRIGPDQLYSVLINGINQSIIGLLIEMIDNKTLVTRKAPTGLVCQSMNHSIFLAPKFRFGTGLTIEVGNYFASNKTLSEDESMAKNLEQALLPSLGNYLGQVGLAEWVESLKEFLLT
Length661
PositionHead
OrganismPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.223
Instability index50.06
Isoelectric point5.40
Molecular weight73279.25
Publications
PubMed=21536894

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.25|      34|     155|     136|     190|       1
---------------------------------------------------------------------------
  146-  180 (59.18/57.82)	LAPLAPDAVDTT..SLPLPPGGIAPMTHSLDhLSPQP
  283-  318 (57.07/19.46)	LEPLNLDDHESTqiSLKLPPRPRRRLAITLA.LPNQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.07|      46|     155|     447|     498|       2
---------------------------------------------------------------------------
  447-  498 (69.36/66.36)	LEPVL....GLTVffiytyNLHNLF..SQAVSDLKPTKLEVEAELDPILESASGMVNL
  597-  648 (67.71/48.61)	LAPKFrfgtGLTI......EVGNYFasNKTLSEDESMAKNLEQALLPSLGNYLGQVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.53|      20|     155|      84|     103|       4
---------------------------------------------------------------------------
   84-  103 (34.44/23.19)	AKPVSELEVPKSNEDDAAEN
  242-  261 (30.09/19.27)	AKPGVDMSLMGRGAERAAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      49.92|      10|      34|     192|     201|       5
---------------------------------------------------------------------------
  192-  201 (17.36/ 9.88)	LMRKRKAAQN
  213-  222 (16.01/ 8.60)	LGREAKRSQN
  227-  236 (16.55/ 9.11)	LLKLREAGWN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.62|       9|      26|      28|      37|       7
---------------------------------------------------------------------------
   28-   37 (12.45/11.18)	LTAAQKdTLW
   57-   65 (17.18/ 9.58)	LTSNLK.RLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26570 with Med17 domain of Kingdom Fungi
Unable to open file!