<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26563
Description |
Mediator complex subunit 14 |
Sequence | MAPVQLENHQLVPPGGGGGASGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAAEREDTPVMALLLQQFKENVQELVFRTKPGKQPRTGPKRKLSDDPCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1454 |
Position | Tail |
Organism | Canis lupus familiaris (Dog) (Canis familiaris) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.190 |
Instability index | 51.55 |
Isoelectric point | 8.97 |
Molecular weight | 160691.85 |
Publications | PubMed=16341006
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:Ensembl
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP26563
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 220.08| 32| 32| 1036| 1067| 1
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10- 32 (34.58/12.17) QL...VP..................PGGGGGASGGPA...SAPAPPP......
1006- 1026 (24.58/ 6.35) ...............................QQPFPKQPGSSGAYPLTSP.PT
1027- 1063 (48.50/20.27) SYhstVN................qsPSMMHTQSPGNLHAASSPSGALRAPSPA
1064- 1097 (46.62/19.18) SF...VP................tpPPSSHGISIGPGASFASPHGTLDPSSPY
1098- 1123 (36.47/13.27) TM...VS..................PSGRAGNWPGS.PQVSGPSPATR.....
1152- 1199 (29.34/ 9.12) QT...LPtnmppprklpqrswaasiPTIL.THSALNILLLPSPTPGL.VPGLA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.03| 24| 30| 1326| 1351| 2
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1326- 1351 (43.68/29.06) PdqATQLKWNVQFC..LTIPPSAPPIAP
1355- 1380 (39.36/20.05) P..AVVLKSKMLFFlqLTQKTSVPPQEP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.19| 29| 30| 69| 97| 3
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69- 97 (46.39/32.55) LTDLLPRKSDVERKIEIVQFASRTRQLFV
102- 130 (48.79/34.62) LVKWANNAGKVEKCAMISSFLDQQAILFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 212.75| 64| 161| 294| 359| 6
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295- 359 (109.88/76.62) CLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTI
446- 515 (102.87/62.87) CGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.33| 10| 29| 1402| 1411| 7
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1402- 1411 (17.56/10.57) PRQQNSSVAA
1428- 1437 (19.77/12.98) PRQGECTIFA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.49| 14| 29| 168| 181| 8
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168- 181 (26.30/13.50) RLPTCIRDKII....PPD
194- 211 (19.19/ 7.79) QLNQILRHRLVttdlPPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.39| 11| 29| 360| 370| 9
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360- 370 (19.13/12.97) KIDENDVSKPL
391- 401 (18.26/12.01) KIDHLSIEKLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.34| 19| 34| 518| 540| 11
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518- 540 (26.57/26.50) ETLQLSNYSTHpignLSKNKLFI
553- 571 (35.76/22.39) EMLEVPNKPTQ....LSYKYYFM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.60| 14| 37| 1247| 1261| 14
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1247- 1261 (21.47/15.65) LKCRVALSP.KTNqTL
1285- 1299 (22.14/11.00) FETRVAGPPfKAN.TL
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