<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26559

Description Mediator of RNA polymerase II transcription subunit 19
SequenceDRAGAEETMENFSALFGAQADPPPPPSALGFGPGKPPPPPPPPPGGGPGTAPPSTAATAPPGADKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGGSQASSSSSLR
Length252
PositionHead
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.04
Grand average of hydropathy-1.030
Instability index62.94
Isoelectric point9.72
Molecular weight27021.41
Publications
PubMed=16341006

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.25|      15|      17|      22|      36|       1
---------------------------------------------------------------------------
   34-   50 (29.00/ 7.59)	GKPppPPPPPPGGGPGT
   58-   72 (28.25/ 7.22)	TAP..PGADKSAAGCGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.62|      40|      46|      76|     121|       2
---------------------------------------------------------------------------
   76-  119 (68.72/51.15)	MRELPGSTELTGSTNLITHYN.LEHSYNKFCGkkvkEKLSNF......LPD
  123-  169 (62.90/32.92)	MIDLPGSHDNSSLRSLIEKPPiLGGSFNPITG....TMLAGFrlhtgpLPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.91|      16|      17|     198|     213|       3
---------------------------------------------------------------------------
  178-  191 (25.73/10.77)	P..PKKKNKHKHKQSR
  198-  213 (27.40/11.89)	PETPSDSDHKKKKKKK
  217-  232 (26.77/11.47)	PERKRKKKEKKKKKNR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26559 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DRAGAEETMENFSALFGAQADPPPPPSALGFGPGKPPPPPPPPPGGGPGTAPPSTAATAPPGAD
2) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPIT
3) TMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGGSQASSSSSLR
1
116
155
64
153
252










Molecular Recognition Features






MoRF SequenceStartStop




1) DRAGAEETMENFSALFGAQ
2) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDH
3) LGFGPGKPPP
1
203
29
19
237
38