Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDSLSIASIPYPELLAYAQSLSAFTSAPPNMPDQNIPGRPPPPLLFPPFPNEEKMRRGHLNAEAPLGLLGETHSVGKAPTVSPKGPDAHQHGANPYRHDLRAPQPDLFNLELDLDLNPDL |
Length | 120 |
Position | Middle |
Organism | Moniliophthora perniciosa (strain FA553 / isolate CP02) (Witches'-broom disease fungus) (Marasmius perniciosus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Marasmiaceae> Moniliophthora. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.528 |
Instability index | 56.86 |
Isoelectric point | 5.14 |
Molecular weight | 13029.56 |
Publications | PubMed=19019209 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26551 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.50| 25| 52| 14| 38| 2 --------------------------------------------------------------------------- 14- 38 (44.48/22.50) LLAYAQSLSAFTSAPPNMPDQNIPG 68- 92 (45.02/22.85) LLGETHSVGKAPTVSPKGPDAHQHG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KGPDAHQHGANPYRHDLRAPQPDLFNLELDLDLN 2) LLFPPFPNEEKMRRGHLNAEAPLGLLGETHSVGKAP 3) LSIASIPYPELLAYAQSLSAFTSA | 84 44 4 | 117 79 27 |
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