<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26541

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMGILYEKRPLKRPRLGPPDVYPQEPKQKEDELTSTNVKHGFPTMPQLSHEFGTARDSIVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGCKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKVQEYYHMGNHVASTNNNNTTPNNSCNSNGSTGTNNSNNNTSNNSNVNNNNASNSNGSTNNQPPTPTSSSQPATGNTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCSNVETNSNPQSPSITKNEVNGSKEIAVVIQGPPNPLTVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGMTTTKVLAALDALDRHSFDKMDAANSLDTLYAKIFTPPPKDSSNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSVCSNGSPPVLPIFQPLLMKFLDVDAPVLDNTSAQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVPDHGRAMDYDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETYSQHECNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAITMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTSLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSSCSLLKTKPHGVEAFSNAYPKIRTALYSALQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSPAFYIDVLNQVDVQDLSIHNSLAVFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDVDMEAEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAGKQPPKKADVPLSHSSKGGGPASVGVGVGVSSSGPGELSISHILGTSDILGGSDDLGLDLAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDTMLTPRQAQRLLHMICYPETATEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSNELSQWLDTVAKAAIDVFQLNNTLSNKPDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKAAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKQCSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSPSIRFVRQLLPLPKLTMEVIACEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAIRVERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSAGNVGVGNAGTNGKGKAMKTKRHNRRTKAATPTTPISQQMQQPPSQLQQMAFSNQQAPVAQQPGMFTGQPPQPQQQWYANQQAHTPQQYGYGQQLQPAQVSGPRYERSGMNQSKQALSNMLRMRLPSTQFMGSQQQPNAAPGPVAGPGAFQGMQRQQFIRQQLRAQHGAPGMNPQQGMFAAQQQQQQQQKQQQQQQQQEQQGMYAGIQQGNQKIE
Length2055
PositionKinase
OrganismHarpegnathos saltator (Jerdon's jumping ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Ponerinae> Ponerini> Harpegnathos.
Aromaticity0.06
Grand average of hydropathy-0.441
Instability index49.08
Isoelectric point6.89
Molecular weight227762.90
Publications
PubMed=20798317

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.86|      23|      24|    1875|    1897|       1
---------------------------------------------------------------------------
 1875- 1895 (35.42/14.76)	.....PISQQ....MQQPPSQLQQMAFSNQ
 1896- 1921 (39.77/17.51)	QA...PVAQQpgmfTGQPP.QPQQQWYANQ
 1997- 2022 (31.04/11.99)	QFirqQLRAQ....HGAPGMNPQQGMFAAQ
 2023- 2040 (30.62/11.72)	QQ......QQ....QQQKQQQQQQQ..QEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.78|      29|      41|     193|     232|       2
---------------------------------------------------------------------------
  184-  227 (44.62/49.66)	TGTLIkflkdqlskvqeyyHMGNHVaSTNNNNTTPN......NSCNS.NGS
  228-  254 (33.67/18.00)	TGTNN.......................SNNNTSNNsnvnnnNASNS.NGS
  255-  269 (21.51/ 8.27)	..TNN.........................QPPTPT......SS..S.QPA
  361-  385 (33.98/15.05)	...................HMCSNV.ETNSNPQSPS......ITKNEvNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.11|      22|      23|     715|     736|       3
---------------------------------------------------------------------------
  715-  736 (40.26/25.10)	KL..EV.PDHGRAMDYDDSKIDDDL
  738-  762 (28.86/15.75)	KLlqHIkEDQQNSMDAPDSPKEDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.82|      15|      15|    1293|    1307|       4
---------------------------------------------------------------------------
 1293- 1307 (25.87/13.61)	VPLSHSSKGGGPASV
 1309- 1323 (23.86/11.95)	VGVGVSSSGPGELSI
 1326- 1339 (20.09/ 8.81)	I.LGTSDILGGSDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.53|      15|      15|     323|     337|       5
---------------------------------------------------------------------------
  297-  313 (20.16/12.38)	EEGLLdrQELLQWILEL
  323-  337 (24.31/16.81)	EDGIL..KLLLPLALQY
  339-  353 (24.06/16.54)	EEFIQ..SELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.63|      15|      18|     532|     549|       6
---------------------------------------------------------------------------
  539-  555 (18.25/16.57)	AKIFtPPPKDSsNERDT
  556-  570 (23.38/ 7.74)	KTEY.NPQQDS.AVVEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.19|      13|      17|    1372|    1387|       7
---------------------------------------------------------------------------
 1372- 1384 (25.04/ 9.79)	QICSQEWVLERCL
 1389- 1401 (22.15/13.77)	ELCHQDMLLDTML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      13|      17|     984|     997|       8
---------------------------------------------------------------------------
  984-  997 (21.88/17.06)	CkVVKHVSN.PSDCS
 1002- 1015 (21.94/11.79)	C.VLAHLYDlYSSCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.10|      36|      41|      60|      99|       9
---------------------------------------------------------------------------
   60-   99 (54.41/36.18)	VTA.AKVG..AYFNAILAKKEELAtmpdTGRKRQQINPKDNFW
  101-  139 (51.69/25.27)	VTArTKNGieAWFKDLSGCKPLVA....LAKKAPNFNKKEEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.22|      13|      17|    1117|    1129|      11
---------------------------------------------------------------------------
 1117- 1129 (25.88/17.50)	CCNA.LNAEWLGVL
 1133- 1146 (21.33/12.86)	CCSSnSPAFYIDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.38|      18|      19|    1485|    1502|      12
---------------------------------------------------------------------------
 1485- 1502 (31.25/17.56)	SNKPDKKSGSIWLVAPLV
 1503- 1520 (24.41/11.99)	SKLPSAVQGRVLKVAGQV
 1532- 1548 (21.72/ 9.80)	RERGRSKSPSLFNHQPF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      75.95|      11|      19|    1966|    1976|      13
---------------------------------------------------------------------------
 1926- 1936 (19.97/ 9.43)	PQQYGYGQQLQ
 1937- 1946 (16.32/ 6.23)	PA.QVSGPRYE
 1966- 1976 (20.65/10.02)	PSTQFMGSQQQ
 1987- 1996 (19.01/ 8.59)	PGA.FQGMQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.34|      12|      41|    1817|    1828|      14
---------------------------------------------------------------------------
 1817- 1828 (21.60/12.94)	KKESEPGKADTP
 1861- 1872 (21.74/13.08)	KRHNRRTKAATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.78|      16|      19|    1228|    1243|      15
---------------------------------------------------------------------------
 1228- 1243 (31.06/20.12)	YSV..STSPHPLPSG..NSR
 1245- 1264 (19.72/ 9.59)	YSIklSCDRHLLAAAhnNIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.61|      10|      19|     660|     669|      16
---------------------------------------------------------------------------
  660-  669 (18.40/ 9.31)	ELIRHDVFSH
  681-  690 (17.22/ 8.30)	DLIQGPVASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.76|      19|      46|     391|     409|      17
---------------------------------------------------------------------------
  391-  409 (37.39/22.20)	VIQ..GPPNPLTVAFN................DYLTC
  422-  458 (23.38/10.86)	IIQviTLECPTALVWNsvgegkapsvlngsplDYLPC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26541 with Med12 domain of Kingdom Metazoa
Unable to open file!