<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26535

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMQKYCSELTERLLKSLDKEYNVIDMGVVVDIISVLEKTTITKEVLEVTRLGKHINELRRKTDNDALARRAKDLVRRWRDMVLPSAHSTPQPTPADTAPPALNGAKPHSPALRSLKPHSPALRGLKPQSPLLKDATSLRVLSPALSLHSDHSRSPNAPLNKQSIISTSNHRISSTNVSPVFGSSSQNHTTEAVPRTHSSNKRLRKENNNKDQRHYYQAPLEFTQSMFEVEESAVKRQRHNGENTSGSLNLQVPSPTLKERISSDRFAETSLETANDTGPKKRGRKKGSKSAKRQAPLKDCVKEKLASISRNPKLKTTQELLADLRGANCSSSAVGASVLPSQSGVAEPPSMEDILRGNSSEQVSKYLRCSQKNSSHRKSPISETSSDSRAQVSRGYKSTENCRERSPESCQERSRDDRTDVAAGSSTCRSSPRRELTVEEILAKLPPLDLKSIDWSDCEAAELTDERNGVECSPRREPTVEDLERLQTQCVEGLNGNYQARLPSTACTNDNDGEQRLMTNQGNEVSVGLSNTGGVKSVYNNQTDGAEFQEWHQMLARPSYQGETLHILPYVIID
Length573
PositionUnknown
OrganismHarpegnathos saltator (Jerdon's jumping ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Ponerinae> Ponerini> Harpegnathos.
Aromaticity0.03
Grand average of hydropathy-0.851
Instability index60.58
Isoelectric point9.02
Molecular weight63473.15
Publications
PubMed=20798317

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26535
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.96|      19|      22|      99|     120|       1
---------------------------------------------------------------------------
  101-  119 (38.20/22.88)	LNGAKPHSPALR...SLKPHSP
  121-  142 (27.76/12.24)	LRGLKPQSPLLKdatSLRVLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.71|      30|      39|     406|     444|       2
---------------------------------------------------------------------------
  406-  443 (41.46/39.35)	PESCQ..ERS.......RDDRTDVaagssTCrsSPRRELTVEEiLAK
  446-  484 (45.24/22.86)	PLDLKsiDWSdceaaelTDERNGV.....EC..SPRREPTVED.LER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     238.02|      81|      86|     170|     253|       3
---------------------------------------------------------------------------
  170-  238 (95.71/53.75)	...............................................RISSTNVSPVFGSSSQNHTTEAVPRTHSSNKRLRKENNNKDQRhyyQAPLE..FTQSMFEVEES.AVKRQRH
  239-  318 (101.49/49.81)	NGENTSGS.LNLQV.PS.........................ptlkeRISSDR....FAETSLETANDTGPK.....KRGRKKGSKSAKR...QAPLKdcVKEKLASISRNpKLKTTQE
  324-  403 (40.82/15.41)	RGANCSSSaVGASVlPSqsgvaeppsmedilrgnsseqvskylrcsqKNSSHRKSPISETSSDSRA..QVSRGYKSTENCRE.....................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26535 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KYLRCSQKNSSHRKSPISETSSDSRAQVSRGYKSTENCRERSPESCQERSRDDRTDVAAGSSTCRSSPRRELTVEEILA
2) MFEVEESAVKRQRHNGENTSGSLNLQVPSPTLKERISSDRFAETSLETANDTGPKKRGRKKGSKSAKRQAPLKDCVKEKLASIS
3) RDMVLPSAHSTPQPTPADTAPPALNGAKPHSPALRSLKPHSPALRGLKPQSPLLKDATSLRVLSPALSLHSDHSRSPNAPLNKQSIISTSNHRISSTNVSPVFGSSSQNHTTEAVPRTHSSNKRLRKENNNKDQRHYYQAPLEF
4) RLPSTACTNDNDGEQRLMTNQGNEVSVGLSNTGGVK
364
225
78
500
442
308
221
535










Molecular Recognition Features






MoRF SequenceStartStop




1) APLKDCVKE
2) KKRGRKKG
3) WRDMVL
294
279
77
302
286
82