<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26531

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIVQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITHAEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLVEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQSRYVHQVIQSRLAESTNPLSEVYYILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDDYTAGKCLSISYWRELTSKDPRSELGYKLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYIRTRSRLSELKQELQTMLKDVECTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTTALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATAHERLPILHHPDHPMSKISRHRMFVQLHRHPTVILIVAFKEKESSPCEIECTFYLAVVKPSTVEDDPHDDNIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSEVVEMTSNNKRRSTGIGGRTDAAGSSQSRRPKHPAYFIPELAHVVALCDERIPFVTLAQELSKREIAHQGLQIEANATALVLKLVQLPAPSPSIATSSAWYALLKRLLSVSIRIQGKGMAKTWTAEFVFYGSPLSSSHPKEQGLRRPIYFQYEMGAADTVARTVDTLLNDWAQIVHLYTIVHDLAEYFKMEKYNLRNMVSIKSYNYSKLVLAYGPNQGATVTVQWSINDKAFRLLFGKSPTNTIPNAHSIMKEQLEAHLNRHMNLAQLIHILHETLQPLTSISKLPTIPQLGVYSNRPQVPVQTFTIMPQSVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDESAVFRRRSQSEDDNPPSPITMDSDGGGGNVGFLGHHRGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQASQHQTFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPGQSPSHAALHSPQATDHKIGSHISRVLPARSWAGAVPTLITHEALDVLCSPSSHPSGLPGPDMCPLERFLGCIYMRRQLQRFIQTEECI
Length1249
PositionTail
OrganismHarpegnathos saltator (Jerdon's jumping ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Ponerinae> Ponerini> Harpegnathos.
Aromaticity0.06
Grand average of hydropathy-0.249
Instability index61.25
Isoelectric point8.40
Molecular weight138818.43
Publications
PubMed=20798317

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26531
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.84|      72|      77|    1059|    1135|       1
---------------------------------------------------------------------------
  981- 1041 (76.70/34.03)	............P.PS..PIT..M...DSDGGG..GNVGFLGHHRgPqSPAqqreGLrfHPPLTPPSGSN...PHTPASP..HTA.NIS
 1050- 1128 (132.93/74.87)	GSSPATSfnLASP.PSLPPNTPNMLPHPSPGSGlvANSPLNPMHV.P.SPA....GL..MPTSSPGPCSNvqvGHSPAGSFMQTG.HID
 1129- 1183 (81.21/36.51)	GSPFPSSqsMASPaASNWPGSPS.VPRPSPA.........RPGQS.P.SHA....AL.................HSPQATDHKIGsHI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.91|      54|      77|     387|     443|       3
---------------------------------------------------------------------------
  387-  443 (86.11/67.33)	RSRLSELKQELQTMLKDVEC..TLAGSPAIL..SVPILQpclRAELLLVTVDTHTGMLQCH
  463-  520 (90.80/61.30)	HSRLPTLISELRFWITQRRCekTLQHLPATAheRLPILH...HPDHPMSKISRHRMFVQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.07|      32|      69|      51|      82|       6
---------------------------------------------------------------------------
   41-   73 (47.07/38.05)	YHELTVLAElLPRKTDMERKIEIYNFSARTRQL
   74-  106 (44.00/35.02)	YVRLLALVKwANSASKVDKSAHIMAFLDKQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.25|      19|     218|     319|     342|       8
---------------------------------------------------------------------------
  319-  340 (22.79/31.41)	RELTSKDprSELGYKlTVQVDQ
  353-  371 (32.46/17.52)	PSLGSKE..SEIAHR.AIRSDQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26531 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPITMDSDGGGGNVGFLGHHRGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQASQHQTFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPGQSPSHAALHSPQATDHKIGSHI
970
1183










Molecular Recognition Features






MoRF SequenceStartStop




NANANA