<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26522

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVMGPIEGMQADVIFVIEGTAVNGAYLNDLKTSYVIPTLEYFSQGAIEDREYVSENSTTLYGIVVYHAADCLPAPCTETFGPYSNPHKLLMMLDKLEMIGGKGESYANIGEGLATGLQCFEDLQLKREPNTASQKHCILICNSPPYQIMIQETYKFAGHTTEQLAAIYQERNINISILSPRKIPALFKLFEKAGGDLKASQKKNYAKDPRHLVLLHNYNLKERSVSPAIGGNVHNTAATTAQIPLSPLQSNDSPNTNQVQQNIAPPNQPQGPPFRNQAPQNITSVHPVQTVAQTMAAPMNAARAPYNSQIAAPPNYHPTVINPRMHTKWMRPFLTPGATTPANTQNSSALIAQLTQPPSLGLNVTTFGQRLDGSNNVMAPNPQQQQQQQQQQLTQQQQQQLRLTMQLQQQNAQQAAMSMAAQSTHNQPGPQLTVSSMNQSVPTQVPQTVAAPQAPVSVSSVTQQIAPPQAQGNVSTGAVQGQQIVQRERQNIWQGILEWIDKAKNPTDTQKQTRHVPCQVSANYKNGEPELKTDTWPPKLIMQLMPKQLIGNIGGSYIKNSKSVIFHPTPCEALESLTKMMSAGFAGCVHFTSIAPNPTCEIKVLILLYTVEKKSYLGFIPNDQTAFVDRLRKVIQQQKISHASMRQGNPGPGNTIPTPMPTTATQGGILMSQTNTTAMGGAQITQSVVSSSAPQMNMQNTGISGPQANVGAGGMITQQRPQFDDLEIARHQNLLKIQHLRQTLEAAQQQEAQYKSQLEVNIQQNLEVAQQQEMQYKQQLEAQQAQRGLNPAAIPNQQANTQQRLMRPVSTNNIGLRHLLQQPQPQYRQQVFGVQQQMVGPRGQIATRPMAPANTQNQQFEDVPNYDFLNCQ
Length872
PositionUnknown
OrganismHarpegnathos saltator (Jerdon's jumping ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Ponerinae> Ponerini> Harpegnathos.
Aromaticity0.05
Grand average of hydropathy-0.526
Instability index50.55
Isoelectric point8.93
Molecular weight95964.71
Publications
PubMed=20798317

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26522
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     238.37|      50|      51|     759|     809|       1
---------------------------------------------------------------------------
  383-  418 (46.61/16.07)	........QQQQQQQQQQL.TQQQQ....QQLR.LTMQLQQQNAQQAAMS........
  740-  761 (39.35/12.42)	LRQTLEAAQQQEAQYKSQLE....................................VN
  762-  815 (84.29/37.50)	IQQNLEVAQQQEMQYKQQLEAQQAQ....RGLNPAAIPNQQANTQQRLMRPVstnnIG
  816-  863 (68.12/27.55)	LRHLL...QQPQPQYRQQVFGVQQQmvgpRG.QIATRPMAPANTQNQQFEDV......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.32|      29|      31|     259|     287|       2
---------------------------------------------------------------------------
  244-  268 (43.89/17.53)	PLSPLQSNDSP.N...TNQVQ...QNIAPPNQ
  269-  300 (51.17/21.70)	PQGPPFRNQAPQNITSVHPVQtvaQTMAAPMN
  442-  469 (47.25/19.46)	PTQVPQTVAAPQAPVSVSSVT...QQIAPP.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.37|      26|      31|     661|     686|       3
---------------------------------------------------------------------------
  538-  558 (32.81/19.66)	PKLIMQ....LMPKQLIGNIGGSYI..
  661-  686 (46.64/31.86)	PTTATQG.GILMSQTNTTAMGGAQITQ
  694-  718 (41.91/27.69)	PQMNMQNtGISGPQANVGA..GGMITQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.10|      28|     221|     349|     382|       5
---------------------------------------------------------------------------
  309-  338 (47.36/23.56)	QIAAPPN..YHPTVINPRMHTKwmRPFLTPGA
  353-  382 (44.74/25.03)	QLTQPPSlgLNVTTFGQRLDGS..NNVMAPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.49|      10|     119|     522|     537|       7
---------------------------------------------------------------------------
  502-  511 (18.29/ 7.11)	KAKNP...TDTQK
  525-  537 (16.20/11.27)	KNGEPelkTDTWP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26522 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EMQYKQQLEAQQAQRGLNPAAIPNQQANTQQRLMRPVSTNNIGLRHLL
2) GAQITQSVVSSSAPQMNMQNTGISGPQANVGAGGMITQQRPQFDDLEIARHQ
3) QKISHASMRQGNPGPGNTIPTPMPTTATQGGILMS
4) VSPAIGGNVHNTAATTAQIPLSPLQSNDSPNTNQVQQNIAPPNQPQGPPFRNQAPQNITSVHPVQTVAQTMAAPMNAARAPYNSQIAAPPNYHPTVINPRMHTKWMRPFLTPGATTPANTQNSSALIAQLTQPPSLGLNVTTFGQRLDGSNNVMAPNPQQQQQQQQQQLTQQQQQQLRLTMQLQQQNAQQAAMSMAAQSTHNQPGPQLTVSSMNQSVPTQVPQTVAAPQAPVSVSSVTQQIAPPQAQGNVSTGAVQG
773
681
638
225
820
732
672
481










Molecular Recognition Features






MoRF SequenceStartStop




NANANA