<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26506

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDDSWKTQSFRQSVIAKIDEAIQMSGMPTTKNSIEMENHVFQKAKSKEEYLGFIARLILHVREMNSKKGAAGNAPGNAGTNNQGMPDPIGALQTLARQGTGNNQMMGIGPGPNHQGIIPQPANTATNLLQSLNQRPGQPMNMPGMQNKMQGMGMMPSQTAGPMSHMGPIQTMQNNPMLTQMNQMGQGNISQQMNQMVSGQMGQLSAGQMQQNMQSQMQNQLPGQMNNQIAGPIGNIQTSMPQQMNQIGPGQLGPGQMQQQLSHIQRKPTEMMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPSRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMISKMSSEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPVTTLKEHQIFSPLLEAVSTHLQSPVINHTLQRTFGPCLDALFGPEIKNLPPPLKKHKVEESPSEIPDVLQGEIARLDQRFKVSLDPAQQNGSKCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNARVAKLPRRFSLSQLLDTWEMSVRQASAPRETSITASTILMGF
Length633
PositionTail
OrganismCamponotus floridanus (Florida carpenter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Camponotus.
Aromaticity0.03
Grand average of hydropathy-0.503
Instability index57.20
Isoelectric point9.39
Molecular weight68765.33
Publications
PubMed=20798317

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26506
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.68|      18|      23|     182|     203|       1
---------------------------------------------------------------------------
  182-  200 (31.65/13.46)	QMNQMgQGNISQQMNQMVS
  262-  279 (25.03/ 6.75)	QLSHI.QRKPTEMMNTGFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.95|      22|      23|     287|     308|       2
---------------------------------------------------------------------------
  105-  146 (28.82/ 8.25)	NQMMGIG...PGPNhqgiIPQPAntatnllqslnqrpgqPMNM.PG
  151-  170 (31.28/ 9.63)	MQGMGMM...PSQT....AGPMS................HMG..P.
  287-  308 (39.79/14.41)	NQFLRQS...PSPS....APSPA................GLGA.PS
  310-  333 (33.46/10.86)	NQMVASPalvPSPS.....PQHA................IMTG.PS
  338-  360 (30.60/ 9.25)	SVGMAPS...PSSS....LNTPG................GVGAtPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.68|      17|      18|     211|     228|       3
---------------------------------------------------------------------------
  214-  240 (22.37/11.61)	NMQSQMqNQL.PGQMNnqiagpignIQT
  241-  261 (26.31/10.11)	SMPQQM.NQIgPGQLG......pgqMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.43|      17|      23|     442|     458|       4
---------------------------------------------------------------------------
  442-  458 (30.55/22.77)	PVTTLKEHQIFSPLLEA
  466-  482 (30.88/23.10)	PVINHTLQRTFGPCLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.06|      16|      29|     370|     385|       5
---------------------------------------------------------------------------
  370-  385 (28.73/19.74)	DKVRQLSKYIE....PLRRM
  396-  415 (22.33/13.75)	DKLSKMKKLLEilsnPSKRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.80|      36|      77|     492|     527|       6
---------------------------------------------------------------------------
  492-  527 (64.40/34.65)	P..PPLKKHKVEESPSEIP...................DVLQGEIARLDQRFKVS..LD
  549-  607 (44.40/21.82)	PcvPPISVTVPADYPSTPPrcvmapheyeattflcavqKALNARVAKLPRRFSLSqlLD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26506 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSKKGAAGNAPGNAGTNNQGMPDPIGALQTLARQGTGNNQMMGIGPGPNHQGIIPQPANTATNLLQSLNQRPGQPMNMPGMQNKMQGMGMMPSQTAGPMSHMGPIQTMQNNPMLTQMNQMGQGNISQQMNQMVSGQMGQLSAGQMQQNMQSQMQNQLPGQMNNQIAGPIGNIQTSMPQQMNQIGPGQLGPGQMQQQLSHIQRKPTEMMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPSRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
66
374










Molecular Recognition Features






MoRF SequenceStartStop




NANANA