<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26499

Description CREB-binding protein
SequenceMADHLVDGPPPKRPKLDPFQGPSDTTVGMAPLMMHHAYTNYGGGGSGNMQQIQGPPQQLHLQQHQLQQHWNNHSIQKRNYITNTEMFDLENDLPDDLLSSGSWGSATESTKPPATGPGPGQQNGALDSELRQHVQQQQQLSHHLIQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGVVDPQMVVSLGNLPSSIASSLANNQMSIANSMGSLQSSMSMTGSNPVMSMPGGMNSGLVMTSSASGNNNMGGMAGGSLIVTNSLNKPLNTVTMMGPNTQAIHHPSGPHGVTSMQNGPGMMNTRTVAMQQQQQAHMVGPARGQSPHQQVHQVGIVAPTQSGPRMQAPPNMTSLPNMGQISASSPYGYGYTNIGGLGSKLCVNNLVGVVKPQQKAVGTNMTAMQAAAAAANRFTGTAGPIGATNVGAQESGTATQQTQPPAPSPAQPQSGASTGGQPGPQGIQGPAGIQGQMVTPTQGAAKSTPDPEKCRLIQQQLVLLLHAHKCQRRENQANGEMRQCTLPDCKTMKNVLNHMTNCQAGKGCTVPHCSMSRQIINHWKHCNRSDCPVCLPIKQANKNRTNSAQAPTIQPNNQPNPSPSEMRRAYDALGIQCPTTTPGLLPGQGVGRGVRMPASGMAGPPGTLGNVRLTTQPQTQTAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVSTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQSGQVTATPVQGTKEWHMSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQQQQQQQLQAQQQQQPQPAGSSGPGLRPCAPPNVGTVIPGTSKPVGTVPPTLRSHSPSMSQLGTIPAMAIQHNRMQFPQQQQQAQQQQQAQQQQQVQVQAQQQIQQQQPGILVGPPGPSPNGQSTSNTMVSNPGLSPFGQPQMSQANLTTTTASNNATTSQFPTSNGTASGLPNSSPIQNQHQFPDLMKVRALTQAQVQAAQQQQQQSQPTSTPNQVGTPVSSIPQAPSPFSGMQQPNAQQQQQSNQQFPNRPLSASTPNDNGIATSTPQTIPPPVSSGPSPTGGMSATTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKGMTSQERAALNTPRNTSMSSQMAAITAALDRDNSPSPPMNNNKGKLDSIKEENIKMEIKQEPEEPQNHRMDGGKSVNNEITIKTEPKTEPMEEGSNEAIVKEEPIGIKEESMTPISGQDATTSDIKPMVPEPIQSSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMETIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVDNGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAANAIFSLSEDSETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCCKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPSGPVGMQTGQQTSNVAMATGVAMKPGVSTSNLPSPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHVSYGKVTPGGGVGVGVGVGVGGQTGGVMPPPQMQRPLPVQMQNPGTHLIPMDQWTASRYQSNTVMQQNPNLARQQTPQQLMQQQQPHQAQPGMAMSAQMPRQPGVIGGQVGPQANMQKHALQQLMQTLRSPHTPEQQNQILQILKSNPPLMAAFIKQRALVHQQQPGQHGGVAGSLAPNQPQQQPGLQHMMSQQQQSQQQQQQQPQQQQQQQQGRLQIQTMLSQQAQQQQPVPQQQWYKQQMIAMQQRAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPSLLGYGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHSTPTHSPAHELGGPSEMMLSQLSGGPGAPTGHPAAMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2664
PositionKinase
OrganismCamponotus floridanus (Florida carpenter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Camponotus.
Aromaticity0.04
Grand average of hydropathy-0.738
Instability index58.75
Isoelectric point9.09
Molecular weight290333.82
Publications
PubMed=20798317

Function

Annotated function Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26499
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.97|      16|      16|    2451|    2466|       1
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  846-  861 (33.35/ 8.69)	Q...QQQQQQQLQAQQQQQ
 2400- 2415 (34.18/ 9.11)	Q...QSQQQQQQQPQQQQQ
 2446- 2464 (29.05/ 6.54)	QmiaMQQRAQQQQQQQQQQ
 2465- 2479 (35.39/ 9.71)	Q...QQQQ.QQQQQQQQQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     350.68|      40|      42|    1039|    1078|       2
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  900-  938 (49.37/11.15)	SH.S......PSMS.QLGT.......................iPAMAIQHNRMQF..P.......QQQQQ......AQQQQQ.....AQQ.
 1006- 1053 (51.58/12.01)	SQfP......TSNGTASGL........................PNSSPIQNQHQF..PdlmkvraLTQAQ......VQAAQQ.....QQQQ
 1054- 1094 (71.94/20.01)	SQ.P......TSTPNQVGT........................PVSSIPQAPSPF..S......gMQQPN......AQQQQQ.....SNQQ
 1103- 1148 (43.48/ 8.83)	ST.PndngiaTSTPQTIPP........................PVSS...GPSPT..G...gmsaTTTTG......TTNG.P.....QSTT
 2489- 2550 (37.02/ 6.29)	.Q.P......PAPPY..GQqrpirpsllgygfneqgygqpglkP..TPPPVPSPQ..G......vMGPPG......ISVQQQ...lmQSVR
 2573- 2615 (45.83/ 9.75)	.Q.P......VPSP.RSG.........................PVPSPHHHP.PHstP.......THSPA......HELGGPsemmlSQLS
 2616- 2657 (51.46/11.96)	GG.P......GA.PT..GH........................PA.AMPHHPSPA..P.......APTNGgadaneVTPMTP.....QDQL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     283.65|      59|      64|    2272|    2330|       3
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 2169- 2212 (46.41/10.26)	.........PHQPG..IGLKPG...TQTP.PAHVLQ.....................................................vVKQVQ.EEAARQQAP............HvsygKVT
 2213- 2295 (78.44/23.08)	PGGGVGVGV....GVgVGGQTGgvmPPPQMQR.PLPVQMqnpgthlipmdqwtasryqsntvmqQN...................PNLA.RQQTP.QQLMQQQQP............H....QAQ
 2296- 2370 (88.78/27.21)	PGMAMSAQMPRQPGV.IGGQVG...PQANMQKHALQQLM......................qtlRS...................PHTP.EQQNQiLQILKSNPPlmaafikqralvH....QQQ
 2371- 2435 (70.01/19.70)	PG.........QHGG.VAGSLA...PNQPQQQPGLQHMM...........................sqqqqsqqqqqqqpqqqqqQQQG.RLQI...QTMLSQQA............Q....QQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.27|      41|      41|     213|     253|       4
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  156-  192 (35.73/12.71)	......................NSLvmaaGTLGNKSPNMQSP......P.....NVSV...SKGVvDPQMVVS
  199-  244 (66.05/30.42)	SIASslANNQM........siaNSM....GSLQSSMSMTGSN......P.....VMSM...PGGM.NSGLVMT
  245-  308 (42.49/16.65)	SSAS..GNNNMggmaggslivtNSL....NKPLNTVTMMGPNtqaihhPsgphgVTSMqngPGMM.NTRTV..
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     270.17|      41|      49|    2018|    2058|       5
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  482-  526 (44.97/18.64)	.............KSTpD...PEKCR.L.IQQQLVLLLHAHKCQRR....EnqangemrqCTLPDCK
  527-  550 (38.32/14.85)	TMK...............................NVLNHMTNCQAG....K........gCTVPHCS
  551-  571 (35.56/13.27)	.MSR.........Q.............I.IN.......HWKHCNRS....D.........C..PVCL
 2018- 2054 (63.98/29.50)	.............KQT.N...PQEARKLSIQRCIQSLVHACQCRDA....N.........CRLPSCC
 2055- 2102 (54.70/24.20)	KMKRvvmhtknckRKT.NggcPI.CKQL.IALC...CYHAKHCQET....K.........CLVPFCS
 2103- 2135 (32.65/11.61)	NIKH.........KIK.Q...QQ....LQ.QR....LQQAQLLRRRmavmN.........TR.PS..
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.22|      50|      53|     334|     385|       6
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  331-  380 (93.05/35.62)	VHQ.VGIVAPTQSGPRMQ..A.PPNMT.SLPNMGQISASSPYGY.......GYTNIGGLGSK
  383-  427 (38.07/12.70)	VNNlVGVVKPQQ.....K..AvGTNMT.AM....QAAAAAANRFtgtagpiGATNVG.....
  428-  472 (55.11/18.62)	.........AQESGTATQqtQ.PPAPSpAQPQSGASTGGQPGPQ.......GIQGPAGIQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     185.37|      46|      49|    1204|    1252|       7
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 1162- 1189 (38.28/14.18)	..................P..NQTVS...S..ASNQTPPHSGPTPS..P......AGLASL
 1190- 1240 (64.07/35.01)	GKG...MT.SQEraalntPR.NTSMS...SQMAAITAALDRDNSPS..PPMNNnkGKLDSI
 1241- 1290 (56.11/28.80)	KEENIkMEIKQE...peePQ.NHRMDggkSVNNEITI...KTEPKT..EPMEE..GSNEAI
 1292- 1319 (26.91/ 7.07)	KEEPI..GIKEE........sMTPIS...GQ..........DATTSdiKPM..........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.29|      12|      24|     608|     619|       8
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  608-  619 (24.41/11.47)	ALGIQCPTTTPG
  634-  645 (21.88/ 9.28)	ASGMAGPPGTLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.36|      19|      79|      50|      71|       9
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   50-   71 (31.84/22.16)	QQIQgppQQLHLQQHQLQQHWN
  132-  150 (34.52/14.82)	QHVQ...QQQQLSHHLIQQQGN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.78|      35|      43|     650|     687|      10
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  650-  684 (61.78/27.52)	TTQPQTQTAPGQSVVGAG...QQVVAPNVSLP..LNSDPS
  690-  723 (32.96/12.49)	GNQTVSTTGPTSAAAAAAaniQQSVNMQTLFG..LN....
  725-  751 (29.04/ 8.47)	......SGQPG..VIG.G...ENRLA.NLQLPggLQSGQV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      49|    1873|    1918|      11
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 1873- 1917 (59.91/52.14)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1922- 1969 (59.49/31.64)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.26|      35|      43|    1320|    1359|      15
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 1320- 1359 (43.68/49.48)	VP..EPI..QSSGTsTDKKKCLFKPDEL...RQALmPTlEKlYrQDP
 1362- 1403 (50.58/30.59)	IPfrQPVdpQALGI.PDYPTIVKKPMDLstiKKKL.DT.EK.Y.SDP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.78|      27|      91|     863|     892|      18
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  863-  892 (45.38/27.34)	QPA...GSSGPGlrPCAPPNVGTVI..PGTSkPVG
  954-  985 (45.40/18.67)	QPGilvGPPGPS..PNGQSTSNTMVsnPGLS.PFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.47|      31|      31|    1810|    1840|      19
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 1776- 1816 (29.37/13.40)	KQAmeDRLSSAADLPYFEgdfwpnvL.EESikELDQEEEEKR
 1817- 1847 (49.00/27.05)	KQA..EAAEAAAANAIFS.......LSEDS..ETPDGKKKGQ
 1848- 1871 (30.10/13.91)	KKA..KKSNKSKANQ.RK.......NSKKS..NTPQ......
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      10|      51|    1673|    1683|      21
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 1673- 1683 (16.71/11.27)	CtPPNTRRVYI
 1726- 1735 (21.33/10.20)	C.PPSEGDDYI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.50|      27|      49|     753|     783|      22
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  753-  783 (41.64/34.03)	ATPVQGtkewHMSVTPDLRNHLVHKLVQAIF
  803-  829 (46.85/27.36)	ARKVEG....DMYEMANSRSEYYHLLAEKIY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26499 with Med12 domain of Kingdom Metazoa
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